49ers-Giants over/under opens at 41
Mon, Sep 21st 8:17pm EDT
This total is very similar to San Francisco's last game against the Jets (coincidentally in the same stadium as this week) as it kicked off at 41.5 points. The 49ers secondary was already banged up coming into last week, and now they can add injuries to two key defensive linemen (Nick Bosa, Solomon Thomas) to the mix. However, what is keeping the total so low is the fact that quarterback Jimmy Garoppolo is questionable with an ankle sprain while Giants running back Saquon Barkley tore his ACL and is out for the season.