Garoppolo and Kittle head list of inactive 49ers against the Giants
Fri, Sep 25th 8:37pm EDT
Given that the spread has remained at 49ers -3.5, oddsmakers likely factored in to some degree the chances that Garoppolo and Kittle would not play. However, the over/under did reach 42 points which is the highest it has been all week. Thus, despite backup quarterback Nick Mullens starting in Garoppolo's place, bettors seem to care more about the 49ers injuries on defense and the possibility they will not be able to slow down the Giants offense as well as they normally would have.