49ers vs. Eagles: NFL Week 13 Odds & Picks (2023)

Gear up for another weekend of NFL action! Make sure to check in with BettingPros throughout the year for top picks and predictions for each and every NFL game. Our writers dive into their favorite picks and predictions for every remaining game on this weekend’s NFL slate. And let’s take a closer look at 49ers vs. Eagles.

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NFL Odds, Picks & Predictions: 49ers vs. Eagles

49ers vs. Eagles

I don’t mean to disrespect the Philadelphia Eagles. They are a really, really good team. But the Eagles are probably fortunate to be sitting at 10-1. Just look at their last two games. The Eagles could’ve lost to the Chiefs two weeks ago had Marquez Valdes-Scantling caught a ball right in his hands. And last week’s win over the Buffalo Bills was more of a Bills collapse than an Eagles comeback. Now, the San Francisco 49ers come to town healthy and with revenge on their minds from last year’s NFC Championship game. I also have concerns about Philadelphia’s defense. The Eagles have some issues in the secondary, where they rank 14th in pass defense EPA. Plus, a Philly run defense that ranks 24th in EPA could be without two key cogs up the middle, Fletcher Cox and Zach Cunningham. The 49ers just have more firepower in this matchup, and while Jalen Hurts and the Philly offense are finding ways to win, this offense just doesn’t look right at times, as evidenced in the first half against Buffalo. San Francisco is the more complete team, and while I bet them earlier in the week at -115 on the moneyline, I’d still back San Fran to win straight up.

Pick: 49ers ML

-Matt Barbato


What is Betting Against the Spread?

Betting “against the spread” refers to the act of choosing the winning team based on a numeric handicap placed on the team that oddsmakers believe is superior, rather than picking the outright winner. For example, if the Rams face the Bengals, and oddsmakers set the spread at Rams -3.5, you would need Los Angeles to win by 4 or more points in order to cash your Rams bet.

What is an Over/Under Bet?

Over/Under is a wager based on how many points you think will be scored in a specific game. Oddsmakers set the total, and bettors decide whether the final score will be higher or lower than that number. If an Over/Under is set at 44.5 points and you bet Over, you will need the combined score of both teams to be 45 points or higher to win your bet.

What is a Moneyline Bet?

A moneyline bet involves choosing which team you believe will win a specific matchup. The moneyline favorite carries a minus designation, like -130. This means that you need to wager $130 to earn a $100 profit. Conversely, the underdog carries a plus designation, like +110. This means that you win $110 in profit on a $100 bet.


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