Best College Football Parlays & Picks: Week 4 (2026)

Week 4 is set up to be the most entertaining slate of the 2026 college football season, with six matchups between current AP Top 25 teams. Notable games include No. 1 Texas vs. No. 14 Tennessee, No. 4 Ole Miss vs. No. 21 Florida, No. 17 Iowa vs. No. 18 Michigan, No. 23 Texas A&M vs. No. 10 LSU, No. 20 Oregon vs. No. 12 USC, and No. 19 Missouri vs. No. 24 Mississippi State.

Ole Miss is in a rare spot, valued as an underdog against an opponent outside of the top 20, despite being inside of the current top 5. Oregon will look to hand USC its first loss of the season, while Arch Manning and the top-ranked Longhorns also embark on their first road trip to a tough environment against the Volunteers at Neyland Stadium.

We’ll watch Mississippi State QB Kamario Taylor command one of the hottest offenses in the country. Iowa and Michigan profile as a low-scoring Big Ten cage match. Texas A&M and LSU will both look to recover from their first losses of the season.

My Best College Football Parlays & Picks: Week 3 (2026) settled 1-2. The winner was an Under parlay for Western Kentucky vs. Indiana/Michigan State vs. Notre Dame at +274 odds. Under 60.5 and Under 51.5 were never in doubt, cashing the longest odds of any Week 3 parlay.

I’ve got three parlays to tail entering the highly anticipated Week 4 college football slate. Follow me on X @Matt_MacKay for more betting analysis and free picks.

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College Football Parlays for Week 4

(Odds courtesy of DraftKings Sportsbook)

Tennessee +4.5/Northwestern vs. Indiana Under 49.5 (+264)

Indiana’s defense under head coach Curt Cignetti could be even better in 2026 than it was during the National Championship run last season. The Hoosiers have held opponents to 16 total points, including consecutive shutouts, while limiting an explosive North Texas offense to 1 touchdown.

Northwestern’s offense has been productive. However, South Dakota State (FCS) and Colorado are far from elite defensive tests. The Wildcats’ defense should hold a bit against Josh Hoover and the Hoosiers, who were a bit sluggish against Western Kentucky in Week 3.

Under 49.5 points between Northwestern and Indiana is the opening leg of this parlay.

Next up, it’s Saturday’s noon kickoff between Tennessee and Texas. The Volunteers’ offense is averaging 47.7 points per game, and now, they’ll host No. 1 Texas as a 4-point underdog in Knoxville. Freshman QB Faizon Brandon has been impressive in head coach Josh Heupel’s offense, racking up 9 total touchdowns and throwing zero interceptions.

While Tennessee may give up points to Manning and the Longhorns, the home crowd will be a new hurdle for Texas to clear. Combined with the Volunteers’ high-flying offense, it’s enough to justify +4.5 to boost this parlay to +264 odds.

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Iowa +5.5/Georgia Moneyline (+122)

Oddsmakers expect a low-scoring grinder of a game when Iowa heads into Ann Arbor to take on Michigan. The Hawkeyes have the nation’s top-scoring defense, allowing just 4.3 points per game, including a 16-13 win over Iowa State.

Kirk Ferentz’s defense and offense play complementary football and are built to win close, low-scoring games. The total sits at just 38.5, but betting the over in this matchup feels like a mistake.

RB Kamari Moulton leads a stable of Iowa running backs that can cycle touches to stay fresh against Michigan’s stout run defense. The Wolverines have allowed explosives in the passing game as well.

However, it’s QB Bryce Underwood’s mistake-prone tendencies that will dig Michigan into a hole against Iowa’s elite defense. It’s why Iowa +5.5 is the first leg of this parlay.

Georgia moneyline is a simple yet effective second leg to take this parlay into plus odds. The Bulldogs have thrashed opponents under head coach Kirby Smart to start this season.

QB Gunner Stockton is playing the best football of his career, posting an 84 percent completion rate for 9 touchdowns and zero interceptions. The same cannot be said of Oklahoma QB John Mateer.

Mateer has failed to lead the Sooners offense above 14 points in back-to-back starts against Michigan and New Mexico. While Michigan is justified, failing to get more than 14 points against the Lobos is shockingly bad.

Georgia is a wagon right now. I’m also willing to lay -14 on the Bulldogs straight, but in this parlay, let’s plug in Georgia’s moneyline at -600 odds, resulting in a +122 parlay.

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USC Moneyline/Mississippi State Moneyline (+240)

Oregon’s been punched in the mouth by Oklahoma State during its road loss in Week 2. The Ducks avenged that outing with an 84-0 rout against Portland State (FCS) in Week 3. It’s created value on USC as a 3-point home underdog.

Lincoln Riley’s Trojans are 4-0 due to QB Jayden Maiava’s 12 touchdowns and 1 interception. Running backs King Miller and Waymond Jordan have split over 100 carries, each averaging over 5.0 YPC.

Oregon’s going to score plenty of points. Expect a track meet, which is why the total sits at 62.5. The Trojans’ defense gave the team a real scare against Rutgers at home last week. However, Maiava can exploit a Ducks defense that allowed Boise State and Oklahoma State to score 3+ touchdowns, including 6.7 YPC against the Cowboys.

USC needs to finally beat Oregon. It’ll happen at the Coliseum on Saturday night, as Dan Lanning’s Ducks don’t have the same juice on defense compared to previous years. USC moneyline is the first leg of this moneyline parlay.

Kamario Taylor’s Heisman Trophy bid is growing after an impressive start as Mississippi State’s QB1. The Bulldogs rallied on the road to beat South Carolina in Week 3, while routing Minnesota on the road in Week 2.

Now, Mississippi State is back in Starkville, facing a talented Missouri program under head coach Eli Drinkwitz. Taylor has thrown for 11 touchdowns, 1 interception, and over 830 yards. Back home, laying a touchdown, let’s back the Bulldogs to win outright with a -238 moneyline leg to bump this moneyline parlay to +240 odds.

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