Best NFL Week 11 Ladder Bets: Picks & Predictions (2025)
There were some massive performances in the NFL in Week 10, led by none other than Jonathan Taylor, who amassed 244 yards and three touchdowns in Germany. Other standout performers were De'Von Achane (174 yards, two touchdowns), Nico Collins (136 yards) and Jalen Nailor (124 yards, one touchdown).
Below, I'll give out three players who I believe are primed for breakout games in Week 11. I'll be betting that each player clears his baseline yardage total, as well as wagering on a few of the higher alternate lines with loftier payouts. Here are my top NFL Week 11 ladder bets.
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Best NFL Week 11 Ladder Bets
(Odds courtesy of bet365)
De'Von Achane Rushing & Receiving Yards
The NFL International Series continues this weekend, and the folks of España are getting treated to a dandy, as the Washington Commanders (3-7) square off against the Miami Dolphins (3-7). Kick-off is scheduled bright and early for 9:30 a.m. ET from Santiago Bernabéu Stadium in Madrid, Spain.
As I mentioned in the intro, Miami's De'Von Achane is coming off a monster outing in the 30-13 win over Buffalo, where he tallied 174 rushing yards and an additional 51 receiving yards. The running back is now averaging 110.5 total yards per game, and he has eclipsed the 121.5-yard threshold three times this year. Achane went for 150+ rushing and receiving yards in two out of the three outings.
Mostly, I like this two-step ladder on Achane because of his workload and the matchup. He is averaging the ninth-most touches among running backs (19.2), and he'll take on a Washington defense ranked 30th in yards allowed per game (394.6). The Commanders are 31st in yards allowed per play (6.4), as well as 23rd in yards allowed per rush (4.6). The crafty Mike McDaniel should be able to get his star back involved. I expect Achane to annihilate this old and slow Washington defense.
Christian McCaffrey Rushing & Receiving Yards
The San Francisco 49ers (6-4) are coming off a 42-26 beating at the hands of the Los Angeles Rams, and they'll try to right the ship this weekend against the Arizona Cardinals (3-6). This NFC West clash gets underway at 4:05 p.m. ET from State Farm Stadium in Glendale, AZ.
This will be the second meeting between the Niners and the Cardinals this season, and it was San Francisco who emerged with a 16-15 home win back in Week 3. Despite the low score, Christian McCaffrey was not held in check that day, registering 140 combined rushing (52) and receiving (88) yards. This was one of six games where McCaffrey broke through the 127.5-yard barrier. He continues to be the biggest workhorse in the NFL, averaging a league-leading 24.9 touches and 131.8 scrimmage yards per contest.
I really don't have too many bad things to say about Arizona's defense, as they're a respectable 15th in yards allowed per play (5.3). The big data point that stands out is that the Cardinals are graded as the worst tackling team in the NFL, per Pro Football Focus (PFF). McCaffrey is clearly a player who can take advantage of this, as he ranks first amongst running backs in yards after contact on receiving plays (153 yards). One broken tackle and it's an automatic chunk play for the superstar back.
CeeDee Lamb Receiving Yards
Week 11 concludes on Monday night with a Sin City showdown, as the Dallas Cowboys (3-5-1) square off against the Las Vegas Raiders (2-7). Kick-off is set for 8:15 p.m. ET from Allegiant Stadium in Las Vegas, NV.
In the five games where CeeDee Lamb has played more than a half, he has gone for at least 85 receiving yards on four occasions. He's averaging 14 yards per catch (25th). Lamb is averaging 10.8 targets per game, which is second in the NFL behind only Ja'Marr Chase (11.9). He has explosive capabilities and is primed to cause damage against a lower-tier Las Vegas defense.
The Raiders are graded by PFF as the 28th-best coverage defense and the 22nd-best tackling group. Las Vegas is allowing its opponents to complete 66.4% of their passes (21st) for an average of 6.5 yards per attempt (15th). Dallas, which passes the ball on 60.9% of its plays (fifth), should shred this secondary. I like Lamb to excel under the primetime lights of Monday Night Football.