Best NFL Week 4 Ladder Bets: Picks & Predictions (2025)
Several players had breakout performances in Week 3 of the NFL season, including a few unsuspecting receivers like Tre Tucker, Courtland Sutton and Ricky Pearsall, who each eclipsed 115 receiving yards. A.J. Brown finally made his presence known in 2025, hauling in six catches for 109 yards and a touchdown in Philadelphia's come-from-behind win over Los Angeles.
I've sifted through the matchups and metrics for Week 4, narrowing in on three candidates primed for big-time performances this weekend. Below, are a trio of players I'm betting will go nuclear, and not only clear their baseline yardage totals, but also climb the ladder and cash a few alternate thresholds as well. Here are my top NFL Week 4 ladder bets.
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Best NFL Week 4 Ladder Bets
(Odds courtesy of bet365)
Jordan Addison Receiving Yards
We have wall-to-wall football on Sunday, and the action gets started across the pond with an intriguing clash between the Vikings (2-1) and the Steelers (2-1). Kick-off is scheduled for 9:30 a.m. ET from Croke Park in Dublin, Ireland.
I'm looking to fade Pittsburgh's defense. They're old and a bit banged up, with linebacker Alex Highsmith (ankle) and cornerback Joey Porter Jr. (hamstring) still working through injuries. The opposition has had its way with the Steelers' secondary this season, as Mike Tomlin's group is ranked 26th in passing yards allowed per game (246.7) and 28th in opposing completion percentage (71.74%). Per Pro Football Focus (PFF), Pittsburgh is the 23rd-best pass coverage team through three weeks.
Initially, I was looking at Justin Jefferson to go off in this game. However, we can get the returning, well-rested Jordan Addison (suspension) at basically half as many yards as we'd need from Jefferson to hit these payouts. Addison really got involved in the offense in the back-half of the 2024 campaign, averaging 8.3 targets, 5.3 catches, and 72.1 yards per game over the final eight contests. He registered 60+ yards in five of those eight games. With a moderately competent quarterback now distributing for the Vikings, I think it's worth riding with Addison to make a major impact in his first game back.
Omarion Hampton Rushing Yards
Onto the early slate of games on Sunday, where I'm narrowing in on this matchup between the Chargers (3-0) and the Giants (0-3). This cross-conference showdown gets started at 1:00 p.m. ET from MetLife Stadium in East Rutherford, NJ.
This New York squad is in shambles, and I don't think it's a hot take to say Brian Daboll's days could be numbered in the Big Apple. While the recently-benched Russell Wilson may take some of the flak, don't forget that the Giants have been absolutely gashed defensively this year. They're allowing 405.3 yards per game (31st), 153.3 rushing yards per contest (31st) and 5.2 yards per rush attempt (28th). The Giants rank 19th in run stoppage (63.5) and 14th in tackling (58.7).
With Najee Harris (achilles) sidelined for the rest of the season, it's time for rookie running back Omarion Hampton to step in and take over the Los Angeles rushing attack. The 22-year-old back is averaging 14 carries per game this year, and he's coming off a 70-yard rushing day against the Broncos last weekend. He's behind one of the better offensive lines in the NFL, and with a matchup against a bottom-tier New York defense, there's a realistic chance that Hampton bags his first 100-yard rushing game in the league.
Jake Ferguson Receiving Yards
All roads lead to a Sunday Night Football clash between the Packers (2-1) and the Cowboys (1-2). These squads are famously linked due to the Micah Parsons trade. The Sunday nightcap gets started at 8:20 p.m. ET from AT&T Stadium in Arlington, TX.
CeeDee Lamb (ankle) is out for several weeks, so his touches have to go somewhere else. Just to hammer home how impactful he has been, Lamb ranked third in the entire league last season in targets per game (10.1). With his early departure last weekend against the Bears, we saw Dak Prescott distribute the ball quite a bit to George Pickens and Jake Ferguson. Ferguson had 13 catches on 14 targets, giving him nine or more receptions in two consecutive games. The tight end has gone for 78 yards and 82 yards in his last two outings. I'll take him to turn in another big performance on the speedy Dallas turf under the bright lights of Sunday Night Football.
I don't have much anti-Green Bay data. But the Packers are 6.5-point favorites, which means they should hold a lead and force the Cowboys into pass-first mode as this game chugs along. This is going to be a recurring theme for Dallas this season, and they have the horses in the receiving game to rack up the meaningless statistics. This is the perfect storm for over bettors and Dallas fantasy owners. Give me Ferguson to have another big night in front of his home fans.