Bills vs. Bears NFL Preseason Week 2 Picks (Sunday)
The 2025 National Football League (NFL) preseason wraps up Week 2 on Sunday with a doubleheader. We have the Jacksonville Jaguars and New Orleans Saints meetings at Caesars Superdome in NOLA at 1 p.m. ET on NFL Network, while the Buffalo Bills and Chicago Bears meet at 8 p.m. ET on FOX.
Let’s build our bankroll with our best NFL preseason picks and bets for Sunday, August 17’s game Bills vs. Bears.
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Sunday’s Best NFL Preseason Picks & Bets: Bills vs. Bears
Odds courtesy of FanDuel Sportsbook | All bets are for 1 unit
Buffalo Bills (+122) at Chicago Bears (-144) | O/U 40.5 (-120/-102)
The Bills (0-1) were on the short end of a 34-25 loss to the New York Giants at Highmark Stadium in Orchard Park, while the Bears played to a 24-24 tie against the Miami Dolphins at Soldier Field.
Bills Mafia is not going to fret about the nine-point loss at home, as QB Josh Allen didn’t play, and RB James Cook was still “holding in” due to “business”, and he was relegated to the exercise bike. A lot changes in a week, though, as Cook has a new deal, and Allen figures to at least make an appearance for a drive or two, if not more. Former Bears QB Mitchell Trubisky also likely will see plenty of action, and he could feed off what is likely to be some boos in his old stomping grounds.
The Bears also did not play their starting quarterback, as QB Caleb Williams sat on the sidelines, with QBs Tyson Bagent and Case Keenum battling for the backup job, playing a majority of the game. Both backups were impressive for Chitown.
The Bears go deep at running back, as rookie RB Kyle Monangai is battling veteran RB Travis Homer for the third-string job, and both figure to get an extensive look. WR Luther Burden III is turning heads in camp, too, as is fellow rookie TE Colston Loveland.
This should be a high-scoring affair, so we’ll go high on the total, like above. Also, let’s take Allen and the Bills catching value on the moneyline in what could be a fun game on FOX.
Picks: Bills Moneyline (+122) & Over 40.5 Points (-120)