Champions League Picks & Predictions: Wednesday (10/21)
The UEFA Champions League has nine matches on tap on Wednesday, 21st. Two matches start at 12:45 p.m. ET, and the rest start at 3:00 p.m. ET. We’ll take a look at a couple of the more intriguing matches with today’s top Champions League picks.
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Wednesday’s Best Champions League Picks
(Odds Courtesy of DraftKings Sportsbook)
Lille (+120) vs. Galatasaray (+210) | Draw (+270) | O/U 2.5 (-160/+130)
In the 12:45 p.m. ET window, Lille (0-0-2) hosts Galatasaray (0-0-2) at Decathlon Arena – Stade Pierre-Mauroy in Lille, France, and the game can be viewed or streamed on Paramount+.
Lille is looking for its first victory in Championship League play, as it suffered a 3-2 loss to Real Betis at home on Sept. 8, while it was blasted 3-0 at Arsenal on Oct. 13.
Galatasaray suffered a 3-1 loss against Portugal Sporting CP on the road, while it was belted by Barcelona 4-1 in a road trip on Oct. 13.
Lille is coming off a 1-1 draw at home against Brest in Ligue 1 play on Saturday, and Lille has scored one of no goals in four consecutive matches across all competitions.
Galatasaray topped Genclerbirligi in the Turkish Super Lig on Saturday, bouncing back from the 4-1 loss to Barca. In Super Lig play, Galatasaray has been tremendous, but it has struggled in the Champions League.
We’ll take Lille on its home pitch for the victory, although the draw is certainly tempting for the chance to nearly triple up. And, we’ll go low on the total at plus-money.
Picks: Lille Moneyline (+120) & Under 2.5 Goals (+130)
Bayern Munich (+105) vs. Arsenal (+225) | Draw (+290) | O/U 3.5 (+110/-135)
At 3:00 p.m. ET, Bayern Munich (1-1-0) and Arsenal (2-0-0) battle at Allianz Arena in Munich, Germany, in one of the more intriguing matchups of the day. It, too can be streamed on Paramount+.
These two European titans have met six times since March 7, 2017, across all competitions. The most recent meeting the Champions League went to Arsenal 3-1 on Nov. 26, 2025, while the home team is 3-0-1 in the past four meetings. The last home match for Bayern Munich, also a UCL matchup, went to Munich in a 1-0 win on April 17, 2024. That was the only clean sheet in the past six meetings, however, as we’ve had an average of 3.3 combined goals per game (GPG) in the span.
Arsenal hammered Lille 3-0 in the most recent Champions League on Oct. 13, while it edged Napoli 1-0 in the first UCL matchup on Sept. 9.
Bayern Munich is unbeaten across the past 10 matchups, posting seven victories and three draws since a 2-0 loss to Paris Saint-Germain in a FIFA Club World Cup match on July 5, 2025. Munich was stunned by Norway Viking FK in a 3-3 draw on Oct. 13. It opened UCL play with a 5-0 pounding of Bodo/Glimt, also a Norwegian club.
We’re going to get plenty of offense, and therefore the Over is a strong play. Let’s also side with Arsenal to get the job done on the road, and it is tempting for the chance to more than double up.
Picks: Arsenal Moneyline (+225) & Over 3.5 Goals (+110)
Real Betis (-175) vs. Feyenoord Rotterdam (+400) | Draw (+380) | O/U 3.5 (+140/-170)
At Estadio La Cartuja in Seville, Spain, Real Betis (2-0-0) hosts Feyenoord Rotterdam (1-0-1) at 3:00 p.m. ET on Paramount+.
These two sides met in a Europa League matchup on Jan. 29, 2026 in this very same venue, with Real Betis coming away with a 2-1 victory. In a Kappa Cup matchup in 2004, Feyenoord posted a victory on penalties, 1:1 (2:3).
Real Betis was roughed up by Barca in a La Liga matchup, 5-2, playing down a man for an extended period. That halted a seven match run with six wins and a draw across all competitions. Betis topped FC Porto 3-2 in an entertaining battle on Oct. 14, while it edged Lille 3-2 on Sept. 8, in its first UCL matchup.
We’re certainly going to play the Over here, and let’s roll with Real Betis as our largest play of the afternoon.
Picks: Real Betis Moneyline (-175) & Over 3.5 Goals (+140)