College Football Week 10 Picks: Best Bets (2026)

Week 10 is set to be one of the best slates in the college football season, featuring 7 matchups between current AP Top 25 programs. There’s no shortage of entertainment value, while stakes continue to grow higher for College Football Playoff eligibility in the final month of the regular season.

Notable games on Saturday include BYU (9) vs. Utah (3), Texas (7) vs. Missouri (19), and Alabama (5) vs. LSU (14). In prime time, there are 3 more high-profile matchups: Kentucky (6) vs. Tennessee (13), Miami (1) vs. Notre Dame (11), and Georgia (2) vs. Ole Miss (10).

My College Football Week 9 Picks: Best Bets (2026) settled 1-2 for a losing week. Iowa’s 30-0 shutout win over Wisconsin helped us cash our only win on Under 36.5 thanks to their stalwart defensive effort. Northwestern +3.5 looked good early until Oregon mounted a second-half rally to win by 8 points. Oklahoma State lost in a 51-49 shootout to Iowa State, falling into a big deficit early to never give a chance at covering -9.5.

I’ve found my 3 favorite college football picks ahead of Saturday’s monster slate. Let’s turn a profit with a 2-1 or 3-0 result.

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College Football Week 10 Picks: Best Bets 

(Odds courtesy of DraftKings Sportsbook)

Kentucky (6) vs. Tennessee (13)

Tennessee hosts Kentucky with a bad taste in their mouth following a late-game meltdown against South Carolina. Coming out of a bye, expect the Volunteers to be more focused, leaning on their top-20 scoring defense, allowing 3 touchdowns only once, which just happened against the Gamecocks.

Kentucky has been one of the biggest Cinderella stories of the year. The Wildcats’ offense doesn’t commit turnovers, but it also sits 40th in scoring, struggling to find the end zone against good defenses like Alabama and Oklahoma.

The point total has crept down from 50.5 to 49.5. We’re still through a key number, so let’s follow this steam and bet Under 49.5 between Kentucky and Tennessee to open our Week 10 betting card.

Pick: Under 49.5  (-112)

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Miami (1) vs. Notre Dame (11)

Darian Mensah leads the undefeated Miami Hurricanes into a second straight road game to take on one-loss Notre Dame. Miami’s quarterback has a scorching hot 80 percent completion rate, throwing for over 2,400 yards and 24 touchdowns to just 1 interception.

Mensah will be without star WR Malachi Toney due to injury in this game. It’s why the Hurricanes have moved from +3.5 to +7.5 in the point spread betting market.

Despite the notable loss, Miami still has RB Mark Fletcher Jr. in the backfield. The Fighting Irish are also just 4-4 ATS this season, while playing one of the weakest schedules amongst any top-ranked program.

Notre Dame’s loss came to a BYU offense that has struggled to produce consistently in the last month. Now, they’ll face the nation’s top-ranked scoring offense, led by a hyper-efficient quarterback, who is getting a full touchdown on the road.

Bet Miami +7.5 on the road against Notre Dame.

Pick: Miami +7.5 (-118)

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Georgia (2) vs. Ole Miss (10)

A top-10 SEC showdown will get underway from Oxford when quarterbacks Gunner Stockton and Trinidad Chambliss go head-to-head on Saturday night. Ole Miss is a +3.5-point home underdog, facing a Georgia defense that ranks as one of the best in the country.

In their two biggest games of the season, Ole Miss has gone 1-1, beating LSU at home, while recently losing to Texas after falling into an early deficit. Georgia bounced back from its only loss of 2026 to Auburn by shutting down Florida 27-8.

The Gators routed Ole Miss earlier this season, exploiting the Rebels’ porous defense. Expect Georgia to have its way with Ole Miss due to the soft matchup on defense, while limiting Chambliss as a passer to win this game.

Since we’re above a key number at Georgia -3.5, I want to play it a bit more conservatively on the moneyline. Lay the juice and back the Bulldogs on the moneyline at -175 odds.

Pick: Georgia Moneyline (-175)

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