College Football Week 10 Picks & Predictions: Penn State vs. Indiana (2022)

Let’s take a look at the College Football Week 10 odds, picks, and predictions for this week’s game: Penn State vs. Indiana.

And check out our other College Football Week 10 game previews and picks:

Check out Thor Nystrom’s Week 10 College Football Power Rankings >>

College Football Week 10 Odds, Picks & Prediction: Penn State vs. Indiana

This line jumped out to not only myself but seemingly the betting public, too, as over 90% of the cash and tickets are on the Nittany Lions as of Wednesday evening. Last week, we saw a rough but competitive game from Penn State against a National Championship contender, Ohio State. Edge defender J.T. Tuimoloau tore apart the Penn State OL and had two sacks, two INTs, a strip sack with a fumble recovery and a TD! The offensive line is an issue but not one that Indiana has can take advantage of as they have no one really in the same neighborhood as Ohio State. Breaking the DL grades from PFF down for the Edge and Interior defensive linemen for Ohio State and Indiana shows it clearly. Of the 18 players (nine for each team) that have logged at least 50 pass rush snaps for each team, Ohio State would have the top eight in Win Percentage with all but one over 10%. Indiana has no players with a win percentage over 10 and grades out as a bottom-10 pass rush team.  

Penn State is ranked, but I wouldn’t consider them a top-tier team. The two teams that were supposed to beat them did (Ohio State and Michigan), and they had some struggles with Northwestern. Fumbles and time of possession were the issues in those games, and I don’t think Indiana is the team that can take advantage of those. Indiana currently has a -4 turnover margin and ranks dead last in TOP.  

Penn State could replace starting QB Sean Clifford as he has been hit-or-miss, but the weapons around him have been outstanding. Duel Freshman RBs Nick Singleton and Kaytron Allen lead a rushing offense that averages 170 rushing yards per game. NFL prospect WR Parker Washington is coming off his best performance of the season, putting up 11-179-1 against Ohio State. In their six wins so far this season, Penn State’s average margin of victory is 21 points. Penn State is probably a little overrated, but Indiana is miserable, and they have dropped four in a row. This one won’t be close; Penn State rolls!

Penn State (-14)

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