MLB Home Run Prop Bet Odds & Picks: Saturday (4/26)

The 2025 MLB season is underway and it's so great to have the sun shining down and baseball to bet on again. Saturday's slate features plenty of games as we continue on a solid start to the season, hitting some metaphorical and literal longshots already. Let’s dive into the top MLB home run picks and predictions for today’s slate. 

Betting on specific players to hit a home run is an exciting way to bet on baseball, and the wins are some of the biggest. The plus-money odds can provide larger payouts that make for some great betting. As a friendly reminder, shop around for the best odds because home run odds differ widely across sportsbooks. Here are some of my favorite players to hit a home run in today's games.

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Last Time: 1-2 | Season: 4-8 (+16.5 Units) | Odds via DraftKings Sportsbook

Saturday's Best MLB Home Run Prop Bets

Carlos Correa (+650)

It's interesting to see how much Carlos Correa has struggled early on this year, but that only means longer odds for taking it deep. I fully believe he's due for a bounce-back soon, and it very well could start on Saturday. He's been a clean 10-for-22 lifetime against Los Angeles Angels starter Yusei Kikuchi with three extra-base hits. Kikuchi has allowed all four of his home runs on the road this year, and all to right-handers.

Correa is also batting .300 this year in a minimal sample size against southpaws. He also has his only home run against lefties. The overarching stats don't look great, but Kikuchi isn't immune to giving up longballs, and the splits are all favorable for one where I'm willing to pay the long odds on it happening.


Tyler Soderstrom (+450)

I usually try to find some solid historical matchup data to help make my home run bets, but here it's more about how Tyler Soderstrom has been mauling righties, owning a 1.092 OPS in his 83 plate appearances so far, with eight of his MLB league-leading nine home runs coming in such at-bats.

Jonathan Cannon has allowed all of his home runs on the road this year, letting up a .875 OPS with a 7.80 ERA. He's also been more generous to left-handed foes and has allowed a long ball in three of his last four starts. The A's catcher/first baseman started the year hot, with nine homers, but he hasn't hit one in seven straight games. He is due to get to double-digits and take back the outright league lead. 


Brandon Lowe (+550)

I went with Brandon Lowe last week and am going right back to the well as Tampa Bay takes on Dylan Cease and the Padres. Fool me once, shame on me. Fool me twice, shame on me again, actually. Lowe has three longballs on the season, and they've all been against right-handed pitchers.

Lowe has seen Cease the best out of anyone on the team, going 4-for-10 against the San Diego starter with a homer under his belt. His odds weren't great last time out, but they shouldn't have dropped even further when he's batting second in the lineup and gets at least four, if not five, cracks at it against a struggling Cease. 


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