MLB Same Game Parlay Odds & Picks: Thursday (4/10)

Two weeks into the MLB season and I finally get to make another MLB bet. I count down the days until Thursday (spoiler alert:  there are six days in between every Thursday) when I get to make a bet for you lovely people. Let’s build a same-game parlay (SGP) betting card together for Thursday, April 10th.

We’ll begin with some important stats through 2025 to help find an angle for today. It’s a limited slate, so we might as well go through all the teams.

2025 Team OPS Ranking 

  • Phillies – 4th
  • Brewers – 9th
  • Red Sox – 10th
  • Angels – 12th
  • Rays – 14th
  • Blue Jays – 17th
  • Guardians – 18th
  • Rockies – 19th
  • Braves – 24th
  • Royals – 25th
  • Twins – 27th
  • White Sox – 28th

2025 Team Walk Rate Ranking 

  • Phillies – 2nd
  • Braves – 5th
  • Guardians – 6th
  • Red Sox – 9th
  • Blue Jays – 14th
  • White Sox – 15th
  • Angels – 18th
  • Brewers – 21st
  • Rays – 23rd
  • Rockies – 25th
  • Royals – 27th
  • Twins – 29th

Let’s look to fade the White Sox today as they face a better Guardians team in Cleveland. This is a bottom-tier White Sox offense, while the Guardians’ offense is humming along.

Get instant alerts when a line reaches your target via the BettingPros App >>

Thursday’s Best MLB Same Game Parlay Picks

(Odds Courtesy of FanDuel Sportsbook)

Chicago White Sox at Cleveland Guardians


Leg #1: Guardians Moneyline (-220)

The Guardians pull this out in a game that is never really in doubt. The highest difference in stats from above, and a -220 Moneyline is usually a sweet spot of Vegas agreeing this matchup is lopsided.


Leg #2: Gavin Williams Under 5.5 Strikeouts (-102)

Despite the White Sox ranking in the bottom five in almost every offensive category, they are in the top 10 in strikeout rate. This stat is a little surprising, though, which is why there is action on Gavin Williams over 5.5 strikeouts (-128) on FanDuel Sportsbook. I think it’s a trap. There is no way Williams goes more than six innings. I get a chance to take under a strikeout an inning from a pitcher with a career 1.35 WHIP facing a top-10 team in strikeout rate? Sign me up.


Leg #3: Carlos Santana to Record a Hit (-165)

Highest average on the Guardians against righties? Check.

Batting in the three-hole? Check.

Old but healthy? Check.

I didn’t draft Carlos Santana in fantasy, but he’s a good bet when he’s in a good situation and healthy. I’m more worried about him getting walks than outs. Which is a good sign for my Guardians Moneyline leg of this parlay. 

Parlay Odds: +331


Make sure to check out our other best bets for Thursday:

Try Premium for FREE in our mobile app