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NFL Parlays & Picks: Best Bets for Week 4 (2025)

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NFL Week 3 delivered a lot of chaos, with upsets and shutouts, while also preserving undefeated records. Unfortunately, neither of my NFL Parlays & Picks: Best Bets for Week 3 settled as wins.

The first parlay lost on the wild ending sequence between the Rams and Eagles, as Philadelphia blocked the Rams’ walk-off field goal attempt for a touchdown, failing to hit Rams +3.5. Meanwhile, the second parlay was a total whiff, with the Saints +7 and Cowboys +1.5 both suffering double-digit losses on the road against the Seahawks and Bears.

I’m back with two NFL parlays, each worth one unit, to tail ahead of Week 4. Follow me on X at Matt_MacKay_ for more NFL betting analysis and free picks.

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                              NFL Early Week Parlays: Week 4

                              (Odds courtesy of FanDuel Sportsbook)

                              Parlay 1 (+221)

                              Leg 1: Minnesota Vikings Moneyline (-146)

                              The first Sunday game in Week 4 will feature a pair of 2-1 teams, when the Minnesota Vikings and Pittsburgh Steelers go head-to-head at Croke Stadium in Ireland for the NFL Dublin Game. The Vikings just routed the Bengals 48-10 with QB Carson Wentz under center, while Aaron Rodgers led the Steelers to a 21-14 road win against New England.

                              Vikings DC Brian Flores has developed Minnesota’s defense into a top-10 unit since he arrived in 2023. Pittsburgh’s offense wasn’t highly productive against a mediocre Patriots defense in Week 3, while it was unable to break 20 points at home against Seattle in Week 2.

                              Conversely, Wentz and the Vikings finished with over 350 yards of offense against Cincinnati. Assuming Wentz remains QB1 in place of an injured J.J. McCarthy, he’ll go up against a Steelers defense that has surrendered between 369 and 395 yards of offense to the Jets, Seahawks, and Patriots.

                              Minnesota head coach Kevin O’Connell is a great play-caller, plus, he’s got a ton of skilled position talent surrounding Wentz. The veteran quarterback is going to want to make the most of his opportunity as a starter in this offense, so expect the Vikings to wind up moving the football with relative ease against a surprisingly weak Pittsburgh defense.

                              Bet on the Vikings moneyline to start this first NFL Week 4 two-leg parlay.

                              Leg 2: Tampa Bay Buccaneers +3 (-110)

                              Baker Mayfield and the Tampa Bay Buccaneers have been a thorn in the Philadelphia Eagles’ side for the past few seasons. The Buccaneers specialize in stopping the run, which is how the Eagles prefer to scheme their offense with RB Saquon Barkley and Jalen Hurts.

                              Mayfield has also led the Buccaneers on a game-winning drive in three straight matchups to start 2025. He’s yet to throw an interception, while the Eagles have allowed 119 or more rushing yards in all three games played.

                              Bucky Irving is going to be the key factor in this game. Tampa Bay’s RB1 had a breakout campaign under former OC Liam Coen. He’s kept it going in 2025, recording between 14-25 carries every game this season, opening up effective play-action passes from Mayfield.

                              This game is being played at Raymond James Stadium, which makes me like the Buccaneers as a home underdog. Until we see Mayfield and the offense start to cool off and regress, there’s no reason to fade them at +3, even against the defending Super Bowl champions.

                              Bet on Tampa Bay to cover +3 as the second leg of this NFL Week 4 parlay.

                              Parlay 2 (+186)

                              Leg 1: Carolina Panthers +5.5 (-110)

                              It felt like Carolina’s late surge in Arizona during Week 2 was going to lead to better results. It showed up in Week 3, with the Panthers shutting out Atlanta 30-0 for a statement win against a divisional opponent coming off of a prime-time win against Minnesota.

                              Carolina goes back on the road as a +5.5 point underdog against New England in Week 4. This feels like too many points to lay with the Patriots.

                              Bryce Young has built strong rapport with top-10 draft pick, wideout Tetairoa McMillan, while the Panthers’ defense is one of the best teams in the league in terms of takeaways. Carolina played poorly on offense against Jacksonville in Week 1, then overcame a sluggish start against the Cardinals to manage covering late in that loss.

                              New England is a young team slowly going through a rebuild. Losses to the Raiders and a porous Pittsburgh defense signal that the team is still a work in progress under head coach Mike Vrabel, even with a rising star in QB Drake Maye.

                              Bet on Young and the scrappy Panthers to cover +5.5 on the road in Foxboro against the Patriots.

                              Leg 2: Los Angeles Rams Moneyline (-200)

                              Los Angeles somehow failed to cover +3.5 against the Philadelphia Eagles in Week 3, despite building an early lead and having an opportunity for a walk-off field goal attempt. Now, QB Matthew Stafford and head coach Sean McVay return to SoFi Stadium laying -3.5 against the 3-0 Indianapolis Colts.
                              Daniel Jones has revived his career as the Colts’ QB1 in 2025. Indianapolis beat Denver with a walk-off field goal in Week 2, blew out Miami in Week 1, then routed the Tennessee Titans on the road to grab their first divisional win during Week 3.
                              The Colts’ hot streak will end against the Rams in Week 4. Los Angeles has a defense that has not yet allowed any offense its faced to record 300 yards, while forcing at least one turnover in each game.
                              Stafford and the Rams’ offense is red-hot, recording 296-439 yards of offense against the Texans, Titans, and Eagles. The Colts’ defense is decent, ranked 13th in yards per play allowed and 12th in total points allowed. Yet they’ve played two bad offenses, while Denver’s offense has not looked dominant with Bo Nix under center.
                              Los Angeles will have a full week to stew on their disappointing loss that ended their undefeated record. Now, they get to host a team with a ton of hype that they’ll look to extinguish on Sunday afternoon.
                              I don’t want to lay -3.5 since it’s through a key number. Instead, let’s bet on the Rams’ moneyline to boost this second NFL parlay to +186 odds.

                              Matthew MacKay is a featured writer for BettingPros and FantasyPros. For more from Matthew, check out hisarchive and follow him @Matt_MacKay_.

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