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NFL Week 1 Odds, Picks & Predictions: 49ers vs. Bears (2022)

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Here is our preview and best bet for the 2022 NFL Week 1 game between the 49ers vs. Bears.

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NFL Week 1 Odds, Picks & Predictions: 49ers vs. Bears

This is a nightmare matchup for a Bears offensive line that ranked dead last in allowed sack rate in 2021. Nick Bosa and the rest of the 49ers pass rush that finished top 5 in sack rate should be living in the Chicago backfield all day. Justin Fields is capable of using his feet to make plays when the pocket breaks down, but the Bears got weaker at the pass-catching positions to bail him out.

On the other side of the ball, there’s hope second-year QB Trey Lance can add explosiveness to the offense. It’s often not wise to take a young quarterback on the road, with limited experience, laying a touchdown, but this matchup is tailor-made for the 49ers.

Picks: Lean 49ers -7 | Lean u41


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