NFL Week 1 Totals Odds, Picks & Predictions (2025)
The 2025 National Football League (NFL) regular season kicks off Thursday night in Philadelphia, with a game on Friday in Brazil. I am very excited to be a part of this piece, as for years I wrote the Total Talk column for VegasInsider.com.
While there are all kinds of other avenues for betting on football, my first love will always be betting totals. It’s the first thing I look for each week, and I’m glad to share some insight with you during the 2025 NFL season.
Let’s build our bankroll with our best NFL Week 1 totals picks.
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Best NFL Week 1 Totals Picks
Odds courtesy of FanDuel Sportsbook | All bets are for 1 unit
Miami Dolphins (-108) at Indianapolis Colts (-108) | O/U 46.5 (-115/-105)
The Dolphins and Colts hook up at Lucas Oil Field in Indianapolis, and if you’re old school enough, you remember when this was a divisional game.
The Colts turn to Daniel Jones to run the offense, as former first-round pick Anthony Richardson is the backup quarterback now. The Dolphins still have Tua Tagovailoa and Tyreek Hill, while De’Von Achane will be front and center, as long as he is 100%. He enters the game as a bit of a question mark due to a calf injury, and he was limited in practice on Wednesday.
The Under went 9-8 for the Dolphins last season, and the under was 4-1 in the final five road games for Miami last season. Meanwhile, the over was 10-7 for the Colts in 2024. These teams met in Week 7 last season, with Indianapolis coming away with a 16-10 victory, not coming close to the total of 44.
With Jones leading the offense, we’ll side with the under here. Indianapolis’ offense could get off to a slow start, and when they do move the ball effectively, it will be with Jonathan Taylor. Running the ball runs the clock, which under bettors love.
Picks: Under 46.5 Points (-105)
The Buccaneers and Falcons meet in an NFC South Division game, and as usual, this will have huge ramifications in the divisional race later in the season.
When these teams hooked up last season, Atlanta ended up sweeping the two-game series, with the Falcons winning 36-30 at home in overtime as the over (43.5) easily cashed, while Atlanta won 31-26 in Tampa in late October with a total of 48.
The over has hit in three straight meetings in this series, while going 4-1 in the past five battles, and 7-3 in the past 10 meetings since December 20th, 2020.
The Bucs will be without Chris Godwin, but Mike Evans is still in a Tampa uniform, and he had seven grabs for 62 yards and two scores last season in Atlanta, while he missed the other game. However, he has three touchdowns in the past three meetings, and the Bucs’ offense figures to be strong again. It should get off to a quick start on the fast track at Mercedes-Benz Stadium.
The Falcons have Michael Penix Jr. and the dynamic Bijan Robinson running the show. The latter can run and catch effectively. When these teams get together, we get a lot of fireworks usually. Expect more on Sunday.
Picks: Over 47.5 Points (-118)
In another divisional matchup, we get the Bengals and the Browns. Last season, the under cashed in both meetings in this Battle of Ohio, with the Bengals averaging 22.5 points per game in those matchups, and the Browns averaging just 10.
The under is 5-1-1 in the past six installments of this AFC North series since January 9th, 2022.
Cleveland turns to 40-year-old veteran quarterback Joe Flacco to keep the seat warm until rookies Dillon Gabriel or Shedeur Sanders are deemed ready to go. This Browns offense is a mish-mash. Yes, Jerry Jeudy is exciting and David Njoku is productive, especially in the red zone, but can the aging Flacco exhibit enough mobility and quickness to get rid of the ball and create downfield?
The Cincinnati offense certainly should be explosive. There are stars all over the field, with Joe Burrow, Chase Brown, Ja’Marr Chase and Tee Higgins. Still, EDGE rusher Myles Garrett will give chase, pressuring Burrow, and he’ll be a major disruptor, as usual. Cleveland’s defense has been able to do a good job routinely against Cincinnati. Even if the Bengals get into the high 20s or even the 30s, can Cleveland get to the teens? This offense looks pretty shabby on paper. Go low.
Picks: Under 47.5 Points (-105)
Detroit Lions at Green Bay Packers | O/U 47.5 (-110/-110)
In yet another divisional matchup in Week 1, the Lions and Packers square off in Lambeau Field.
The big Packers news in recent weeks was the acquisition of defensive superstar Micah Parsons. However, it remains to be seen if he’ll play in Week 1, as he has some minor injury concerns, and the team is trying to get him up to speed with the game plan.
For the Lions, they swept the season series in 2024, but the under cashed in a 24-14 win in Lambeau Field on November 3rd. The under is 2-1 in the past three meetings in Wisconsin, too.
Green Bay has some injury issues on offense, too, which is cause for a little concern. Jayden Reed has been nicked up, Dontayvion Wicks is a question mark, thrusting rookie Matthew Golden into action as the top receiver option.
Expect a bit of a slow go from the Packers early on before they get their sea legs. And, expect the Lions to see a bit of a slow start in a tough place to play, especially when opening the season. Going low is the way to go.
Picks: Under 47.5 Points (-105)