NFL Week 10 Same Game Parlays: Bills vs. Colts (2024)

NFL Week 10 is here, and it’s time to lock in some best bets and props before the games kick off. Picking matchups against the spread and betting on the over/under is more commonplace, but a Same Game Parlay (SGP) gives us even more added action. Let’s find some plus-money SGP picks for every game on the NFL Week 10 Sunday afternoon slate.

Keep in mind the odds below are accurate as of writing but are always subject to change up until kickoff. Keep track of any of the latest NFL injury news and odds movement before locking in any of these SGP bets. Here are all of our best NFL Week 10 Same Game Parlay bets. And below we dive into our favorite NFL Week 10 same game parlay for Bills vs. Colts.

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NFL Week 10 Same Game Parlays: Bills vs. Colts

(Odds courtesy of DraftKings Sportsbook)

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Bills vs. Colts

At 7-2 and on a four-game winning streak, the Bills look like one of the league's best teams. On the flip side, the 4-5 Colts have suffered back-to-back losses and are trending in the wrong direction. Most of the stats, matchups, and vibes point to Buffalo as the deserving favourite. Yet, we're going with Indianapolis to kick off this SGP. 

First, this is a weird sandwich spot for the Bills. They could be in for a letdown after just beating the division-rival Dolphins at home on a game-winning field goal last week. Buffalo will then host the Chiefs in a marquee AFC matchup next week. In between, there's this inconsequential road game at Indy.

Meanwhile, the Colts should be plenty motivated after losing one-possession games in the past two weeks. In fact, all five of Indianapolis' losses this year have been by one score. The Colts have been a covering machine this season, going 7-2 ATS overall and 5-1 ATS as underdogs. They are also 4-0 ATS at home so far. Indy failed to cover last week at Minnesota but was right in the game until the final minutes of the fourth quarter. 

The big discussion surrounding the Colts is the benching of Anthony Richardson in favor of Joe Flacco. The offense was admittedly underwhelming with Flacco under center last week. Still, Flacco (64.4% completion rate, 94.5 QB rating) is the more efficient passer than Richardson (44.4%, 57.2). Plus, a home matchup against the more-beatable Bills defense presents optimism. Buffalo also allowed 27 points and 373 total yards to Miami and could be worn out here. 

Josh Downs has emerged as Flacco's clear favourite target. He has 6+ receptions in all four games that Flacco has played this season and 7+ in three of four. He's also led the team in catches and targets in each Flacco game. Downs is seeing heavy involvement as the short-yardage pass-catcher for quick completions, and that should continue as long as Flacco is at quarterback. Plus, the Bills have struggled to cover running backs and slot receivers all season with their zone coverage schemes. 

The Colts are allowing the second-most rushing yards per game in the league (149.8). Buffalo should have success on the ground with James Cook as the lead back. Cook had just 44 rush yards on 10 carries last game, but his day could've been a lot better with more touches. Two games ago, Cook racked up 111 yards on 17 carries. With the Bills dealing with multiple injuries in the receiving corps, the game plan could feature Cook and the run game. 

Parlay Odds: +700

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