NFL Week 17 Pick’em Pool Predictions (2025)
There are huge matchups all over the NFL schedule this week. On Saturday, the Houston Texans and Los Angeles Chargers will meet in a battle of two of the hottest teams in the AFC. Later that night, the Green Bay Packers will try to clinch a playoff berth, while the Baltimore Ravens will hope to keep their season alive. Then, on Sunday, the Buffalo Bills host the Philadelphia Eagles, and the San Francisco 49ers host the Chicago Bears. Below are my top NFL Week 17 pick’em pool predictions.
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NFL Week 17 Pick’em Pool Predictions (2025)
Houston Texans vs. Los Angeles Chargers
The Texans looked half-asleep in Sunday's win over the hapless Raiders, but they got the job done, holding on for a 23-21 win. While the performance was a bit alarming, the Texans have still won seven consecutive games, with victories over the Jaguars, Bills, Colts and the Patrick Mahomes-led Chiefs during that span.
While the Chargers have won four consecutive games, I'm very concerned about their offensive line in this matchup. The Texans have recorded 41 sacks, tied for the sixth-most in the league. Meanwhile, the Chargers have given up 51 points, tied for the fourth-most.
The Chargers may try to offset the Texans' pass rush with the run game, but they won't find much success, as the Texans rank fourth-best against the run, allowing just 96.2 yards per game. The only thing that could potentially hurt the Texans is their offense, but the unit is averaging 25.4 points per game during the current winning streak.
Pick: Houston Texans
Baltimore Ravens vs. Green Bay Packers
The Packers just need one more win to clinch a playoff spot, but the quarterback situation in Green Bay is seriously problematic entering this weekend. Jordan Love is still in concussion protocol, while backup Malik Willis, who played well against the Bears, is dealing with a shoulder injury. If neither quarterback is available for Saturday, Clayton Tune would likely be the starter.
But the Ravens are dealing with quarterback issues of their own. Lamar Jackson left Sunday night's game with a back injury, and he's currently questionable for Saturday. However, I'm more confident in the Ravens' quarterback situation. If Jackson is unable to play, the backup is Tyler Huntley, who was 9-of-10 last week and has already seen meaningful action in three games this season.
If this game comes down to the running backs, the edge goes to Derrick Henry over Josh Jacobs. Jacobs disappeared from Saturday's loss, and as a running back dealing with a lingering knee injury, it wouldn't be surprising to see his workload minimized here. The Packers are having a lot of bad luck, but even with a loss, they wouldn't be eliminated this week. The same can't be said for the Ravens. Take the healthier and more desperate team.
Pick: Baltimore Ravens
Philadelphia Eagles vs. Buffalo Bills
The Eagles' offense has come to life over the last two weeks, scoring at least 29 points in each contest. However, those two performances came against the Raiders and Commanders, two of the worst teams in football.
Though Josh Allen is dealing with an injury, he was able to play all of last week's game against the Browns, and it would be shocking to see him miss this contest. While the Eagles are allowing just 19.3 points per game, the Bills' offense at full strength should be able to do plenty of scoring, as the team ranks fourth in the league with 28.9 points per game.
The easiest way to beat the Bills is via the run, but the Eagles rank just 15th in rushing offense. The Eagles also have the 10th-worst passing attack, which will be a huge problem for them against the Bills' second-ranked pass defense. I expect the Bills to make the Eagles one-dimensional, and the Eagles' inconsistent rushing attack to struggle even in a great matchup.
Pick: Buffalo Bills
Chicago Bears vs. San Francisco 49ers
Both of these teams clinched playoff berths in Week 16, but that doesn't mean they don't have plenty to play for this week. Both teams are still very much alive for the NFC's top seed, and the Bears can clinch the NFC North with a victory or a Packers loss this week.
Caleb Williams made some incredible plays late against the Packers last week, as he finished the game with 250 yards and two touchdowns. He now gets to face a 49ers defense allowing 229.3 passing yards per game. That said, the Bears have the second-ranked rushing attack in the league, but if they try to rely too much on that unit on Sunday, they could run into trouble, as the 49ers rank eighth in rush defense.
Ultimately, I think this game will come down to Christian McCaffrey. The Bears rank sixth-worst in the league against the run, and the pass defense ranks 18th. McCaffrey leads the 49ers in both receiving and rushing yards, and he's scored in all but four games this season. The Bears keep finding ways to win even when all hope looks lost, but I think their luck runs out on the road against the 49ers.
Pick: San Francisco 49ers
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Phil Wood is a featured writer at BettingPros. For more from Phil, check out his archive and follow him @Phil_Wood_Jr.