NFL Week 18 Same Game Parlays: 49ers vs. Cardinals (2025)
We made it! NFL Week 18 is here, and it’s time to lock in some best bets and props before the games kick off. The Sunday Week 18 slate is a loaded with playoff implications, divisional matchups, and tons of ways to go for props and picks. Let’s dive into every game on the afternoon slate and find some winners.
Picking matchups against the spread (ATS) and betting on the over/under is more commonplace, but a same-game parlay (SGP) gives us even more added action. Let’s find some plus-money SGP picks for every game on the NFL Week 18 Sunday afternoon slate.
Keep in mind the odds below are accurate as of writing but are always subject to change up until kick-off. Keep track of any of the latest NFL injury news and odds movement before locking in any of these SGP bets. Here are our favorite NFL Week 18 same game parlays. Below we dive into our top NFL Week 18 same game parlay for 49ers vs. Cardinals.
Get instant alerts when a line reaches your target via the BettingPros App >>
Best NFLWeek 18 Same Game Parlays: 49ers vs. Cardinals
(Odds via DraftKings Sportsbook unless noted otherwise)
49ers vs. Cardinals
- Leg 1: Cardinals -4.5 Spread (-110)
- Leg 2: Kyler Murray Over 33.5 Rushing Yards (-125)
- Leg 3: Michael Carter Anytime Touchdown (+125)
This NFC West matchup is one of the few Week 18 games featuring teams who are both already eliminated from playoff contention. We also have a pair of squads stuck in losing skids recently. The Cardinals are 1-5 over the past six games as they collapsed late. The 49ers are 1-6 over the past seven and have lost three straight.
The situations for both teams are pretty ugly right now but we should have more confidence in Arizona at home. The 49ers will start Josh Dobbs at quarterback with Brock Purdy injured. Despite Dobbs' scrambling ability, this downgrades an offense that's been struggling lately anyway. We also have to wonder about San Fran's motivation at this point in a lost season for the reigning NFC champs.
Arizona put up just nine points against the Rams last week but still gained 396 total yards of offense. We should see Kyler Murray and the attack have success against a 49ers defense that's allowing 28 PPG on the road this year. San Francisco is also 0-3 ATS as underdogs this season and 0-5 ATS as dogs over the past three years combined. Meanwhile, the Cardinals are 4-1 ATS in their last five home games.
Murray is still one of the best running quarterbacks in the league and his rushing yards line looks like a bargain this week. His 550 rush yards this season are the most he's had since 2020, averaging a career-high 7.3 yards per carry. Murray is running for 34.4 yards per game and he has 30+ in half of the games this year. Notably, Murray has run for 83, 49, 75, and 91 yards in four of his last five matchups vs. San Francisco.
Michael Carter is in line to be the Cardinals' lead back with James Conner placed on IR. Carter stepped up with 81 total yards on 15 touches last week after Conner got hurt. He didn't score but has a great shot at doing so at home here. The 49ers have allowed 22 rushing touchdowns this season, the second-most in the league.
Parlay Odds: +435