NFL Week 18 Same Game Parlays: Bills vs. Patriots (2025)

We made it! NFL Week 18 is here, and it’s time to lock in some best bets and props before the games kick off. The Sunday Week 18 slate is a loaded with playoff implications, divisional matchups, and tons of ways to go for props and picks. Let’s dive into every game on the afternoon slate and find some winners.

Picking matchups against the spread (ATS) and betting on the over/under is more commonplace, but a same-game parlay (SGP) gives us even more added action. Let’s find some plus-money SGP picks for every game on the NFL Week 18 Sunday afternoon slate.

Keep in mind the odds below are accurate as of writing but are always subject to change up until kick-off. Keep track of any of the latest NFL injury news and odds movement before locking in any of these SGP bets. Here are our favorite NFL Week 18 same game parlays. Below we dive into our top NFL Week 18 same game parlay for Bills vs. Patriots.

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Best NFLWeek 18 Same Game Parlays: Bills vs. Patriots

(Odds via DraftKings Sportsbook unless noted otherwise)

Bills vs. Patriots

  • Leg 1: Under 36.5 Total Points (-112)
  • Leg 2: 1st Half Under 17.5 Points (-110)
  • Leg 3: Bills Team Total Under 20.5 Points (-130)
  • Leg 4: Patriots Team Total Under 17.5 Points (-142)
  • Leg 5: Bills Moneyline (-155)

This may be the toughest Week 18 game to handicap. The Bills are locked into the AFC No. 2 seed and have nothing to play for. We know Josh Allen will start and play a handful of snaps to keep his consecutive games streak going, but he'll give way to Mitch Trubisky early. Buffalo is expected to rest many other starters as well with a playoff game coming up next week. 

Meanwhile, the Patriots are on a six-game losing streak and just got blown out at home by the Chargers, 40-7. Drake Maye is dealing with an injury to his throwing hand but is still likely to start this week. Even if he does start, we could see Jacoby Brissett and Joe Milton get some run in the second half. With a loss, New England can lock up the No. 1 pick in the 2025 NFL Draft. 

That situation makes things interesting if it's a close game in the fourth quarter. So, do we trust Mitch Trubisky and the backup Bills or a tanking Patriots team with a banged-up rookie quarterback? Plus, it's expected to be cold and windy in Foxborough on Sunday for this divisional clash. 

Considering all of the factors, offense may be at a premium here. Let's root for a low-scoring game as we grab the under for the first half and full game. Add in the unders for both team totals as well. The final scoreline could easily be 17-13 or around that with a late score or two. 

Finally, we should have more confidence overall in the Bills to win this game. The Patriots got a gift from the Giants' victory last week and are in prime position to pick first in the NFL Draft with a loss this weekend. Of course they won't be trying to lose (wink, wink) - but don't be surprised if Maye and other starters hit the bench late. Jerod Mayo is likely back as head coach so it's not like they'll be trying to win one more for him either. Buffalo also just has that winning mindset right now even if it's Trubisky and the backups. 

Parlay Odds: +420

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