NFL Week 2 Totals Odds, Picks & Predictions (2025)
The 2025 National Football League (NFL) regular season moves to Week 2, and now we’re starting to get valuable information pouring in. It’s one week, but it’s valuable. We will be able to make even better decisions after Week 2, and after we get some meaningful data over the course of a month, we’ll start to see some trends develop, so we can really make some educated plays. For now, we’re going off of short sample sizes, common sense and trends. That’s all we have.
Let’s build our bankroll with our best NFL Week 2 totals picks.
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Best NFL Week 2 Totals Picks
Odds courtesy of FanDuel Sportsbook | All bets are for 1 unit
Buffalo Bills (-310) at New York Jets (+250) | O/U 46.5 (-105/-115)
The Bills played an epic game with the Baltimore Ravens on Sunday Night Football in Week 1. When the dust cleared at Highmark Stadium in Orchard Park, N.Y., the Bills had a 41-40 comeback victory, and, obviously, the Over had been in the bag for some time.
Buffalo played one of the top offenses in the NFL, allowing 432 total yards, including 8.6 yards per play. The Ravens gouged the Bills for 8.2 yards per rush, while amassing 19 first downs and they were 6-of-11 on third-down efficiency. However, the Bills did some major damage, too. They had 497 total yards, a whopping 29 first downs, and 6.4 yards per offensive play, while going for 8.3 yards per play. While Buffalo wasn’t nearly as balanced as Baltimore, the Bills compiled 389 passing yards, and 8.3 yards per pass.
Primetime games were 3-1 in four venues under the lights in Week 1. The rest of the slate saw totals go Under at an 11-1 clip on Sunday day football. In divisional matchups, we saw the Under go 6-2, too. So, what can we expect in this Bills-Jets game in the Meadowlands?
Well, the Jets were involved in that lone Over result in the Sunday day games, falling 34-32 in an epic showdown between Steelers QB Aaron Rodgers, facing his former team, with Jets QB Justin Fields doing the same. Emotions were high, things were heated, and there was a ton of offense. The Jets allowed 271 total yards, while posting 394 total yards of their own. New York gobbled up 182 yards on the ground, with RB Breece Hall going over the century mark. We saw how effective Baltimore was running the ball on Buffalo, so expect Gang Green to try and do the same.
Normally, running the ball runs the clock, and it is good for the Under. Buffalo runs the ball well, too, with a combination of RB James Cook, and QB Josh Allen. However, both of these teams look like they’re going to try and pass the ball frequently, too. Based on the complete lack of defense in Week 1 from both sides, let’s go high on this total, which actually might be a touch to low. Expect things to close near the 48-point mark by Sunday kickoff.
And, just for the record, the Over cashed in both regular-season meetings in 2024, with Buffalo averaging 31.5 PPG in the two games, and New York going for 17.0 PPG.
Picks: Over 46.5 Points (-105)
The Seahawks and Steelers meet in an AFC vs. NFC meeting in the Steel City in Week 2, and it’s Seattle's first road game, and the home opener for Pittsburgh.
The Seahawks were on the short end of a 17-13 score last weekend against the San Francisco 49ers at Lumen Field, and the offense was a bit on the choppy side for Mike Macdonald’s team. RB Zach Charbonnet actually played more snaps than RB Kenneth Walker III, who might not quite be 100 percent recovered from his ACL, and QB Sam Darnold looked more like the guy the Jets and Carolina Panthers gave up on, than the guy who tore it up in Minnesota last season. The 49ers defense had a lot to do with that, though.
The Steelers offense was crisp last week in New York, topping the Jets 34-32 in the only Over of the Sunday afternoon games in the opening weekend, as the total went high three other times, all in primetime games.
We saw just two interconference games in Week 1, and the total went low in both of the outings. Does that mean we go low on Sunday in this game, though? Absolutely not.
This is a super low total, and the Steelers nearly surpassed this mark on their own last week. Rodgers did have an ax to grind against the Jets, so perhaps we can expect some regression, but the offense looked awfully impressive in the first go-around on the road.
The Steelers cashed the Under at a 6-2 clip at home last season, including the final four games, but they also didn’t have Rodgers and WR DK Metcalf. Oh yeah, Metcalf is playing his former team this week, so it’s another reunion game, and his fire should be burning white-hot. Go high, and enjoy the result.
Picks: Over 39.5 Points (-118)
It’s another divisional game, and the second straight for both of these teams to open the 2025 campaign.
The Bears played a boring three quarters on Monday Night Football against the Minnesota Vikings in Week 1 before all hell broke loose in the fourth quarter. There were just 23 combined points on the board after 45 minutes, and 28 points scored in the final 15, as the Bears forgot how to play defense all of a sudden.
For the Lions, they were shut down in a 27-13 loss in Green Bay. Detroit is breaking in two new coordinators, and former OC Ben Johnson is now the head honcho in Chitown. His offense was choppy in Week 1, and is a work in progress. Eventually, he could do big things. The Lions looked choppy, too. They totaled just 246 yards, with a pedestrian 4.7 yards per pass attempt, going for exactly 200 passing yards. Rushing the ball was not an option, amassing just 46 yards, or 2.1 yards per attempt, while Detroit was a dismal 1-of-4 in the red zone and 5-of-15 on third-down efficiency.
The Under is 3-1 in the past four meetings at Ford Field, too. This might not be a defensive slog, but the total is a bit high based on what we saw from each offense in the opening performances.
Picks: Under 47.5 Points (-118)
Atlanta Falcons (+154) at Minnesota Vikings (-184) | O/U 44.5 (-110/-110)
On Sunday Night Football, the Vikings make their second appearance in primetime in as many weeks. Hmm, I don’t know how to feel about that, but they looked good on Monday, at least for 15 minutes. QB J.J. McCarthy got it together in the final quarter after looking brutal, at times, in the first half. RB Jordan Mason showed tremendous burst, pairing with RB Aaron Jones for what could be a strong one-two punch in the backfield.
Atlanta was a kick away from an Over result. Down 23-20, PK Younghoe Koo missed a field goal in the final seconds which would have sent the game to overtime, and a likely Over result, but he pushed it right. QB Michael Penix Jr. was impressive, flirting with 300 yards passing while also rushing for a score. He’ll get a chance to show out on national television, and introduce himself to casual fans who might not be familiar with his game.
The Falcons had some trouble stopping the pass, as Baker Mayfield was able to get the job done through the air in Week 1. That bodes well for McCarthy and WR Justin Jefferson in their home debut.
Let’s keep this one short and sweet, and go high on the primetime total at U.S. Bank Stadium in Minneapolis. Night games often save the best for last, and this is an awfully low total given the fact we have RB Bijan Robinson, who had 100 receiving yards, on one side, and Jefferson on the other. There is a ton of talent capable of housing it every time they touch the ball.
Picks: Over 44.5 Points (-105)