NFL Week 4 First Touchdown Scorers Picks & Predictions (2026)

by Trent Conner |
Oct 03, 2026

Someone must score the first touchdown of the game, and this NFL Week 4 first touchdown scorers article will help you increase your odds of hitting on that player based on matchups and team strengths. I will track my plays here on BettingPros. Let's get to the first touchdown scorer predictions for NFL Week 4.

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NFL Week 4 First Touchdown Scorers Picks & Predictions

New England Patriots @ Buffalo Bills

The Patriots are tied with the Dolphins for the fewest points per game (12). They are struggling on offense, and I would avoid them in this category until proven otherwise. James Cook has scored a touchdown in each of his last two games and has averaged 6.4 yards per carry in each.

Cook ran for 135 yards against Detroit in Week 2, and 154 yards against the Chargers last week. The Patriots allowed 165 rushing yards to running backs in the first two weeks, but gave up 112 yards and two touchdowns to the Jaguars last week. They are allowing 4.2 yards per attempt to the position. Josh Allen was seen limping after last week’s game, but does not carry an injury designation. Allen is always a threat at the goal line, but Cook is a solid play this week against the Patriots.

Pick: James Cook (+500 at DraftKings Sportsbook)

Los Angeles Rams @ Philadelphia Eagles

The Eagles have not scored a point in the first quarter this season, while the Rams average 4.7 first-quarter points. Puka Nacua (hip, groin) has missed the last two games, but practiced in a limited fashion on Wednesday. At the time of writing, he is expected to log a full practice on Thursday, so he is trending towards playing in Week 4.

The Eagles have struggled against wide receivers all season. Last week, they allowed 196 receiving yards and two touchdowns to the position against the Bears. Nacua played 70% of the snaps in Week 1 and saw nine targets. He was targeted once in the red zone, but his ability to make plays with the ball in his hands is outstanding. He should have a great chance of scoring first if he returns to the field.

Pick: Puka Nacua (+850 at DraftKings Sportsbook)

Kansas City Chiefs @ Las Vegas Raiders

Travis Kelce has turned back the clock through the first three weeks of the season. Kenneth Walker III has added a rushing attack to this offense, forcing teams to stack the box, which opens the field for Kelce and company. The Raiders are the third-best matchup for tight ends and allowed four touchdowns to the Saints' tight ends last week.

Kelce only saw two targets against the Dolphins last week, but the Chiefs were in control of the game. He had 16 targets in the first two weeks, which he turned into 12 receptions, 172 yards and a touchdown. He has two red-zone targets this season, both of which have gone for touchdowns. Expect Patrick Mahomes to look his way when it counts this week.

Pick: Travis Kelce (+1000 at FanDuel Sportsbook)

Denver Broncos @ San Francisco 49ers

The Broncos have only scored one touchdown in the first quarter this season and have not scored in their last two games. The 49ers are tied for sixth with 5.7 points per first quarter this season. Brock Purdy has looked amazing this season, throwing nine touchdowns to only one interception. He has used his legs when needed, with 93 yards and a score on the ground.

The Broncos did not contain Mahomes in Week 1, and he scored the first touchdown of the game. The Broncos' secondary may be one of the best in the league, and the 49ers are dealing with a slew of injuries at wide receiver. Purdy may struggle to find open receivers downfield this week, which could force him to use his legs in the red zone. He is a good dart throw this week.

Pick: Brock Purdy (+1800 at FanDuel Sportsbook)

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