NFL Week 7 Early Odds, Picks & Predictions: Chiefs vs. 49ers (2022)

Six underdogs won outright in Week 6, including shocking victories by the Jets over the Packers and the Steelers over the Buccaneers. Additionally, the Falcons moved to a perfect 6-0 against the spread (ATS) this season.

Week 7 features just four opening spreads where a team is favored by a field goal or less, signaling a more lopsided upcoming slate. Let’s take a look at my predictions for Chiefs vs. 49ers.

Go premium to view top prop bets based on Cover Probability, Expected Value & Star Rating >>

NFL Week 7 Early Odds, Picks & Predictions: Chiefs vs. 49ers

Kansas City Chiefs at San Francisco 49ers

Patrick Mahomes was just a home underdog for the first time in his career, and he lost. Now, he looks to get things right with a road trip to San Francisco. The 49ers were destroyed by the Falcons in Week 6, thanks in large part to their defense being riddled with injuries.

The 49ers should get some key pieces back this week, but will it be enough for them to slow down Mahomes and company? This number is small, and it’s hard to imagine it getting smaller. Look for this to move safely above the key number as the week progresses.

  • Current Line: Chiefs -3
  • Predicted Final Line:  Chiefs -4

View 5-star bets and historical prop performance by player with our Prop Bet Analyzer >>


Subscribe: Apple Podcasts | Spotify | Google Podcasts | Stitcher | RadioPublic | Breaker | Castbox | Pocket Casts

Whether you’re new to sports betting or a betting pro, our Sports Betting Strategy and Advice page is for you. You can get started with our 101 section — including 10 Sports Betting Tips for Beginners â€” or head to more advanced strategy — like Key Numbers When Betting Against the Spread â€” to learn more.

Phil Wood is a featured writer at BettingPros. For more from Phil, check out his archive and follow him @Phil_Wood_Jr.