Thursday Night Football Best Bets (Chargers vs. Chiefs)

After an electric opening night on Thursday Night Football between the Buffalo Bills and Los Angeles Rams, the schedule makers of the NFL have blessed us with another exciting matchup between two AFC West juggernauts, the Kansas City Chiefs and Los Angeles Chargers.

Here are our favorite bets and leans for this Week 2 matchup on Thursday night.

Prop Bet Analyzer: View top rated props and historical prop performance by player >>

NFL Week 2 Thursday Night Football Best Bets

Check out our Chargers at Chiefs matchup page.

Kansas City Chiefs (-4) over Los Angeles Chargers
Andy Reid and the Chiefs have the deed to the AFC West. They’ve won the division in each of the last six years, averaging 12 regular-season wins over that span. Kansas City is 33-20-1 ATS against divisional foes during Reid’s tenure. The Chargers are going to be without WR Keenan Allen and CB J.C. Jackson — two big losses in a game that projects to be a shootout with plenty of passing. The Chiefs should comfortably win their home opener.
– Pat Fitzmaurice

BetChiefs -4 (-107, PointsBet)
First Recommended: Chiefs -3 (-110)
Personal Projection
: Chiefs -6.5
Limit: Chiefs -5.5
– Matthew Freedman


  • Kickoff: Thursday, Sept. 15, 2022, 8:15 pm ET
  • Location: Arrowhead Stadium
  • TV: Prime Video

Chargers at Chiefs: Consensus Lines

  • Spread: Chiefs -4
  • Over/Under: 54.5
  • Moneyline: Chiefs -200, Chargers +175

Chargers at Chiefs: Betting Percentages

Data from Action Network and as of Sept. 14.

  • Spread: Chargers – 33% bets, 40% money
  • Over/Under: Under – 28% bets, 55% money
  • Moneyline: Chargers – 35% bets, 44% money

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