Top 6 MLB Picks & Predictions: Wednesday (6/3)
The 2026 Major League Baseball (MLB) regular season rolls on with 15 games today, including four matinee games. We have three first pitches at 1:40 p.m. ET or earlier, and a 3:40 p.m. ET start. We’ll focus on one day game, and the rest on the evening slate of games, including the Cleveland Guardians and New York Yankees on Amazon Prime Video at 7:05 p.m. ET. Let’s build our bankroll with our best MLB picks & predictions for Wednesday, June 3rd.
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Wednesday’s Best MLB Picks & Predictions
Odds courtesy of FanDuel Sportsbook | All bets are for 1 unit
Chicago White Sox (+130) at Minnesota Twins (-154) | O/U 8.5 (-115/-105)
The White Sox (32-29) and Twins (29-33) meet at Target Field in Minneapolis for the series finale at 1:40 p.m. ET on ESPN Unlimited and MLB.TV.
Chicago is looking to salvage the finale on Wednesday after dropping the first two games by a combined score of 15-10, with the over cashing in both games. The White Sox have lost consecutive games for the first time since May 23-24 to follow a five-game winning streak. Chicago hasn’t lost three in a row since May 5-8.
Minnesota has won consecutive games after a five-game losing streak, which included three losses in four games on the South Side of Chicago. The over is on an 8-0 roll for the Twins, including the past five meetings with the ChiSox.
White Sox righty Erick Fedde (0-5, 5.40 ERA, 1.48 WHIP) gets another chance to work it out, while the Twins turn to righty Taj Bradley (5-1, 3.21 ERA, 1.21 WHIP) to complete the sweep. We’ll back the home side to cap off the sweep, and we’ll go high on the total based on Fedde’s giving ways.
Picks: Twins Moneyline (-154) & Over 8.5 Runs (-115)
San Diego Padres (+176) at Philadelphia Phillies (-210) | O/U 7.5 (-115/-105)
The Padres (32-27) and the Phillies (31-29) square off at Citizens Bank Park in Philadelphia at 6:40 p.m. ET, as righty Walker Buehler (3-3, 4.88 ERA, 1.32 WHIP) goes for San Diego, while Philadelphia rolls with lefty Cristopher Sanchez (6-2, 1.47 ERA, 1.12 WHIP). The latter has posted 95 strikeouts across 79.1 innings, ranking second in the Majors in the category.
The Phillies swept the Padres in three late May games at Petco Park, including a pair of 3-0 wins, while outscoring San Diego 10-3. They carried over the momentum into Tuesday’s series opener with a 3-2 win, as the under (8.5) cashed for the fourth time in four meetings in 2026, and the fifth straight time in this series.
San Diego has dropped three in a row, and seven of the past eight outings, while the under is 7-2 in the past nine outings. The under has a 5-4 edge in Buehler’s past nine starts, too.
Philadelphia has posted five wins in the past seven outings, while the under is 9-1 in the past 10 games, 13-2 in the past 15 outings and 17-3 across the past 20 games since May 10th.
Let’s back Philadelphia to get the job done by at least two runs. We’ll go low on the total based on the series trends and the Phillies’ latest trends.
Picks: Phillies -1.5 (-104) & Under 7.5 Runs (-105)
Cleveland Guardians (+128) at New York Yankees (-152) | O/U 7.5 (+100/-122)
The Guardians (35-27) and Yankees (36-24) meet at Yankee Stadium at 7:05 p.m. ET, and the game can be viewed or streamed on Amazon Prime Video.
Cleveland has managed an 18-13 record on the road, while New York has managed a 17-10 mark at home. The Guardians scooped up a 9-4 victory as heavy underdogs (+172) on Tuesday, as the over (7.5) cashed.
While the Yankees have the overwhelming salary and supposed talent, the Guardians are right there with four wins in the past seven meetings. The over on Tuesday snapped a 5-0 run to the under in this series.
Since May 11th, the Guardians are 14-6, while cashing the over in three in a row and five of the past seven outings. The Yankees have won six of the past eight contests, while the over is on a 4-0 run.
Guardians righty Gavin Williams (8-3, 3.07 ERA, 1.09 WHIP) goes for Cleveland. He is 4-2 with a 3.89 ERA on the road in six starts across 37 innings. The Yankees counter with righty Gerrit Cole (1-0, 0.00 ERA, 0.71 WHIP), who hasn’t allowed a run in 12.2 innings in two starts since making his season debut.
Let’s back the Yankees to get the job done, and we’ll go low on the total.
Picks: Yankees Moneyline (-152) & Under 7.5 Runs (-122)
Joe Williams is a featured writer at BettingPros. For more from Joe, check out his archive and follow him @winwithjoe