2025 NFL Combine Betting Guide: Top Prop Bets for PrizePicks & Underdog

by BettingPros Staff |
Feb 27, 2025

The NFL Combine is about to kick into full swing this week. There's nothing better than watching future stars of the NFL perform in Indy while sweating some 40-yard dash times. Andrew Erickson and Derek Brown share their favorite combine props to smash on PrizePicks and Underdog immediately.

2025 NFL Combine Betting Guide: Top Prop Bets

LB Carson Schwesigner under 4.64 40-yard dash (Underdog / PrizePicks)

According to NFL.com's NFL Draft analyst Daniel Jeremiah, UCLA's Carson Schwesigner should test under the 4.65 40-yard dash time. The linebacker has great speed and has been working with EXOS in preparation for the 2025 NFL Scouting Combine. Xavier Worthy trained at EXOS in 2024 before his record-breaking 40-yard dash last year.

– Andrew Erickson

LB Jihaad Campbell under 4.48 (Underdog)

According to Bruce Feldman's 'Freaks List' the explosive Alabama linebacker is expected to run the 40 in the 4.4s. CBS' Chris Trapasso believes that Jihaad Campbell will test better than several WRs in the 40-yard dash.

– Andrew Erickson

EDGE James Pearce Under 4.49 (Underdog)

The Tennessee pass rusher needs a strong combine outing after dealing with some character concerns during the pre-draft process. According to Feldman in the 'Freaks List', Vols coaches claim Pearce is a legit 4.4-caliber talent.

– Andrew Erickson

QB Jalen Milroe under 4.41 (PrizePicks)

One of the best traits that Jalen Milroe possesses is his legs.

The Alabama quarterback knows he can do wonders for his draft stock with a strong athletic performance on Saturday. That should start with a strong outing in the 40-yard dash.

– Andrew Erickson

RB Cameron Skattebo over 4.53 (PrizePicks)

Cam Skattebo is not known for his speed. After his line opened at 4.6 it has been bet down to 4.53 on Prizepicks. RBs typically run slower 40s than we anticipate and I bet that Skattebo leaves much to be desired after he tests in the 40-yard dash. The line should be closer to the 4.6 range like it initially opened. Pedestrian-like 40 time is how it was described in this scouting report by the Athletic.

The undertaker and DBro approves going for the over on the Arizona State RB’s 40 time.

– AE / DB

RB TreVeyon Henderson under 4.41 (PrizePicks / Underdog)

Per Reel Analytics, Henderson is projected to run a 4.39-4.41 40-yard dash at the NFL Combine. The fact that he has also been clocked over 21 mph numerous times leads me to smash the under for Henderson's 40-yard time. The former Buckeye ranked tenth in breakaway run rate last year (per PFF) and should have no problem breaking some stopwatches in Indy.

– Derek Brown

RB Quinshon Judkins under 4.51 (PrizePicks / Underdog)

According to Reel Analytics, the Ohio State RB hit a top-end speed of 21.1 mph in Week 4, which projects to a 4.44-4.46 40-yard dash time. Quinshon Judkins has previously been indicated to have run a 4.49 on his record.

**Update: Judkin’s line has moved to 4.46 (Prizepicks) and 4.49 (Underdog). At those these values, I would avoid this bet unless it moves back to the 4.5 range.*

– Andrew Erickson

Dylan Sampson over 4.39 (Underdog)

Yes, I know Sampson reportedly ran a 4.32 40 in high school. No, I'm not crazy for betting the over for his 4.39. Hear me out. Sampson was clocked at 22-23 mph per Catapult. I couldn't find a published run per Reel Analytics with Sampson eclipsing 21 mph. Reel Analytics also published their top 10 projected 40-yard dash times for running backs, with the highest time coming in at 4.43 (Bayshul Tuten).

Sampson didn't find his name inside the top 10. There are moments in Sampson's film where he is caught behind by defenders on long runs and has had higher than a 36.4% breakaway run rate over the last two collegiate seasons. There's enough uncertainty in the analytics and the film to avoid the public consensus and hit the over for Sampson.

– Derek Brown

WR Isaiah Bond under 4.33 (PrizePicks)

If there is any WR that can run the fastest 40-yard dash and usurp Arian Smith as the fastest, it's Isaiah Bond. The Texas WR is one of the fastest WRs in this year's draft class. Like Smith, he has a prolific track background. University of Texas coaches told Sports Illustrated, Albert Breer, that Bond will run in the 4.2-second range in Indy.

– Andrew Erickson

Omarion Hampton under 4.46 (Underdog)

Hampton's line looks high. Per Reel Analytics, he has been the author of numerous runs of at least 21 mph. Hampton's GPS times have been stout, and per Reel Analytics, he is projected to run between 4.42-4.44 in the 40-yard dash. Hampton could easily coast under this number in Indy.

– Derek Brown

Bonuses

WR Tre Harris UNDER 4.52 (PrizePicks) – AE/DB

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2025 NFL Combine Betting Guide: Top Prop Bets for PrizePicks & Underdog