Arizona vs. Iowa State: College Football Picks (Saturday)
No. 25 Arizona hosts Iowa State at Casino Del Sol Stadium on Saturday, October 24, with kickoff scheduled for 7:30 p.m. ET on ESPN2. The Wildcats enter as 9.5-point favorites, while the total sits at 51.5. Arizona will need a double-digit victory to cover, giving bettors a clear benchmark as they assess the Cyclones' upset chances. Read on for our Arizona vs. Iowa State picks and predictions, college football betting odds and best bets for Week 8.
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College Football Week 8 Bets & Picks: Arizona vs. Iowa State
(Odds and lines via BettingPros’ consensus betting information)
Week 7 of the 2026 college football season featured some incredible performances. Auburn kicker Alex McPherson drilled a 34-yard field goal as time expired to upset No. 1 Georgia 27-24. Tennessee running back DeSean Bishop racked up 175 total yards and two touchdowns in a 26-10 victory over Alabama. The focus now shifts to a Week 8 slate packed with intriguing storylines and ranked programs in action. Here’s a look at our favorite college football picks for Saturday’s game Arizona vs. Iowa State.
Arizona vs. Iowa State Picks
Arizona has been great this season, especially through the air, ranking 10th in passing yards per game (306.7). Iowa State is middling against the pass, ranking 53rd in passing yards allowed per game, 79th in coverage grade, and 60th in pass-rush grade. Iowa State runs the ball well, and West Virginia gashed the Wildcats for 303 rushing yards and 31 points. Luckily for Arizona, WVU's defense is so bad that the Wildcats put up 482 yards and 52 points in only 24:10 of possession, with just one defensive score.
Iowa State's three games that went under the total came when the Cyclones held FCS opponent SEMO to only 10 points and struggled to score against Iowa (13) and at BYU (10). Arizona's unders have been similar: The Wildcats held NAU to seven points in Week 1, scored only 17 points at BYU, and held Cincinnati to seven points.
With Arizona struggling against a strong running game, Iowa State running at the 32nd-highest rate, and both teams averaging 35.6 points per game, the over looks very achievable as Noah Fifita heads into his 41st career start.
Pick: OVER 49.5