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Bears vs. Bills: NFL Preseason Week 1 Odds & Picks (Saturday)

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The 2024 NFL preseason is here! While the NFL preseason isn’t the same as the regular season, it’s still a great opportunity to start scratching your football betting itch. That’s right, you can bet on the 2024 NFL preseason! And we’ll be here to navigate your 2024 NFL preseason betting picks with predictions for each and every game. Here are our top picks and predictions for Week 1 of the 2024 NFL preseason. Below we dive into our top picks for the NFL preseason game: Bears vs. Bills.

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NFL Preseason Week 1 Picks: Bears vs. Bills

Bears vs. Bills

We’ve already seen the Bears once in the preseason, as they topped the Houston Texans in Canton in a weather-shortened Hall of Fame Game. While the Bears are still deciding whether or not No. 1 overall pick QB Caleb Williams will play, the Bills have confirmed QB Josh Allen and the first-teamers will play, as the revamped offense gets a look, albeit a short one. Even one series can make the difference for bettors in a preseason game. However, the Bills do have several injuries to skill positions, with Chase Claypool, KJ Hamler, Mack Hollins and Justin Shorter nursing injuries. However, it’s a good opportunity for rookie wideout Keon Coleman to get some meaningful reps against a pro foe. And, for what it’s worth, these teams met last preseason, with Buffalo winning 24-21 in Chitown, with Allen and the starters playing briefly.

Pick: Bills -2.5 (-110)

  • Daniel Dobish

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