Best College Football Parlays & Picks: Week 2 (2026)

The Week 2 college football slate is gearing up for kickoff, meaning I’ve got three new parlays to build and lock in for a few big matchups this weekend. Notable games inside the AP Top 25 include No. 1 Ohio State vs. No. 4 Texas,  No. 11 Oklahoma vs. Michigan, Arizona vs. No. 15 BYU, and No. 18 Tennessee vs. Georgia Tech.

My Best College Football Parlays & Picks: Week 1 (2026) went 1-2. The winner came during the controversial finish between Western Michigan and Michigan, as we cashed Western Michigan +27.5/Under 48.5 in sweat-free fashion at +196 odds. Stanford got blown out, while Louisville rallied late to cover +6.5, although the high-scoring 4th quarter sailed Over 55.5 points. If you bet 1 unit on each SGP, you’re only down 0.04 units, virtually breaking even.

Let’s turn a profit in Week 2 with my latest college football parlays. Follow me on X @Matt_MacKay for more college football betting analysis and free picks.

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College Football Parlays for Week 2

(Odds courtesy of DraftKings Sportsbook)

Oklahoma Moneyline/Alabama Moneyline (-122)

Oklahoma went from a road underdog to a -5.5 point favorite following Michigan’s walk-off win over Western Michigan in Week 1. The quarterback edge is big, with Sooners QB1 John Mateer’s dual-threat ability far exceeding Bryce Underwood’s skill set.

Underwood struggled against a stout Broncos defense. Now, he’ll have an even bigger challenge against the Sooners, who just shut out UTEP and come in with head coach Brent Venables, who led Oklahoma to the seventh-best scoring defense in 2025. This included a 24-13 win over the Wolverines in Norman. Slot Oklahoma’s moneyline in as the first leg of this moneyline parlay.

Alabama lost QB Ty Simpson but the Crimson Tide ran rampant over East Carolina in Week 1, scoring five rushing touchdowns and logging 227 rushing yards. Freshman QB Keelon  Russell also threw for 256 yards and no turnovers.

Kentucky has been a thorn in the side of SEC opponents when they travel to Lexington. The Wildcats throttled Youngstown State in Week 1 with new head coach Will Stein replacing long-term veteran Mark Stoops.

Alabama should be able to air it out, as Kentucky gave up 246 yards and a touchdown last week. They were stout against the run, but the Wildcats won’t average 6.0 YPC and rack up 6 touchdowns against a Crimson Tide defense that just held ECU under 200 yards, including just 2 total rushing yards.

Let’s roll out this Oklahoma/Alabama moneyline parlay at -122 odds.

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Tennessee -12.5/Under 55.5 (+310)

I’ve got a SGP for this SEC-ACC tilt between No. 18 Tennessee and Georgia Tech on Saturday night. The Yellow Jackets only registered one touchdown via special teams against Colorado at home in Week 1. Now, Georgia Tech faces the Volunteers, who just hung 8 touchdowns on Furman (FCS), racking up over 630 yards of total offense.

Freshman QB Faizon Brandon looked the part during his debut under center for the Volunteers. He’ll play his first road game against Georgia Tech, who just held Colorado to 124 passing yards and 14 points.

The Yellow Jackets were sloppy on offense and couldn’t do much against a Colorado defense that was among the worst in the nation in 2025. Don’t expect a big leap against Tennessee, even though they did allow over 28 points per game under head coach Josh Heupel last season.

Tennessee should win this game by at least 2 touchdowns, although we only need a 13-point win margin to cover -12.5. Under 55.5 hinges on Georgia Tech’s ability to sustain drives and limit an explosive Volunteers offense.

It might be a sweat into the final few minutes, but I predict we’ll see Tennessee post a 45-10 or 38-17 win at Bobby Dodd Stadium in prime-time.

Tennessee -12.5/Under 55.5 generates lucrative +310 odds for this SGP.

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Ohio State Moneyline/Under 49.5 (+256)

The Buckeyes and Longhorns headline the Week 2 college football slate with a massive matchup in Austin on Saturday night. Ohio State ground out a 14-7 win at home to open last season 1-0. Now, Texas, led by QB Arch Manning, seeks revenge on their home turf under the lights.

It’s not often that we see Ohio State as an underdog in any capacity. Now, we’re getting even odds on the Buckeyes, who are loaded with plenty of talent, including a strong connection between QB Julian Sayin and star wideout Jeremiah Smith.

These teams played the same caliber opponent in Week 1 and had nearly identical results, each scoring over 50 points and holding their opponent under 10 points.

I think we’ll see another gritty defensive effort from both teams in this game. It may take a while for explosive plays to happen, while the Buckeyes have an edge in terms of offensive personnel and benefit from new OC Arthur Smith throwing a few wrinkles in the playbook.

If this is anything like last year’s game, Under 49.5 should hit with relative ease. Ohio State needs to win a ranked non-conference road game during the regular season to set the tone for another National Championship run.

Manning is good but not on the same level as Sayin in terms of consistent accuracy. With two elite defenses, I’ll give the edge to Ohio State winning outright as a +1.5 point underdog on the road.

Place one final bet on Ohio State Moneyline/Under 49.5 in a +256 SGP.

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