College Football Week 2 Odds, Picks & Prediction: Duke vs. Northwestern (2022)

Let’s take a look at the College Football Week 2 odds, picks, and predictions for this week’s game: Duke vs. Northwestern.

And check out our other game previews for Week 2:

Check out Thor Nystrom’s Week 2 College Football Power Rankings >>

College Football Week 2 Odds, Picks & Prediction: Duke vs. Northwestern

Northwestern started off their 2022 campaign with an upset win over double-digit favorite Nebraska in Ireland. The expectations for Northwestern in the Big Ten this season were not high, but after the week 0 victory, they’ve jumped from +40000 to +15000 odds to win the conference. This Northwestern team is better than the squad they fielded last season, but the market has overreacted to a game that Nebraska was taking control of before the vicious Groundhog Day that has plagued the Scott Frost era in Lincoln took shape.

Duke routed an overmatched Temple team in week 1 to the tune of 30-0. This marked the Blue Devils’ first time holding an FBS opponent to 17 points or less since 2019. The defense could help them repeat last year’s 30-23 win over Northwestern in week 2. In addition, Duke should be able to move the ball on the Wildcat defense again this season. Quarterback Riley Leonard flashed a dynamic ability on the ground and in the air against Temple that could give Northwestern fits. This is a letdown spot for Northwestern, and Duke is more than capable of pulling off the upset.

Pick: Duke ML (+310)

What is Betting Against the Spread?

Betting “against the spread” refers to the act of choosing the winning team based on a numeric handicap placed on the team that oddsmakers believe is superior, rather than picking the outright winner. For example, if the Rams face the Bengals, and oddsmakers set the spread at Rams -3.5, you would need Los Angeles to win by 4 or more points in order to cash your Rams bet.

What is an Over/Under Bet?

Over/Under is a wager based on how many points you think will be scored in a specific game. Oddsmakers set the total, and bettors decide whether the final score will be higher or lower than that number. If an Over/Under is set at 44.5 points and you bet Over, you will need the combined score of both teams to be 45 points or higher to win your bet.

What is a Moneyline Bet?

A moneyline bet involves choosing which team you believe will win a specific matchup. The moneyline favorite carries a minus designation, like -130. This means that you need to wager $130 to earn a $100 profit. Conversely, the underdog carries a plus designation, like +110. This means that you win $110 in profit on a $100 bet.

Prop Bet Analyzer: View top rated props and historical prop performance by player >>

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