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College Football Week 6 Odds, Picks & Prediction: Missouri vs. Florida (2022)

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Let’s take a look at the College Football Week 6 odds, picks, and predictions for this week’s game: Missouri vs. Florida.

Here are other game previews for Week 6:

And check out our other Week 6 College Football betting content:

Check out Thor Nystrom’s Week 6 College Football Power Rankings >>

College Football Week 6 Odds, Picks & Prediction: Missouri vs. Florida

Missouri’s defense has been stellar to start SEC play. That has been their calling card all year, ranking in the top 40 in SP+ defense and 15th in defensive EPA per play. A near longshot upset over Georgia in week 5 could spell a letdown spot as they travel to Gainesville to take on Florida. However, this is a matchup the Tigers can exploit. Florida’s offense has had moments when it has looked incredibly impressive, but the numbers may be misleading.

Florida took advantage of a gassed Utah defense, pouring on two late touchdowns in week 1 for a statement win after a ho-hum first three quarters. Then against a stout Kentucky defense, they put out their worst offensive output of the year with just 16 points and 279 yards of offense. Missouri will present a similar challenge and should make this a game if the defense can play as well on the road as they have at home.

On the other side of the ball, Missouri is far from explosive, but they were able to move the ball on an elite Georgia defense. They settled for too many field goals in that game. If they can manage to punch in those opportunities, they could find themselves leaving Ben Hill Griffin Stadium with their first SEC win of the season and leave the Gator faithful stunned.

Pick: Missouri ML (+325)

What is Betting Against the Spread?

Betting “against the spread” refers to the act of choosing the winning team based on a numeric handicap placed on the team that oddsmakers believe is superior, rather than picking the outright winner. For example, if the Rams face the Bengals, and oddsmakers set the spread at Rams -3.5, you would need Los Angeles to win by 4 or more points in order to cash your Rams bet.

What is an Over/Under Bet?

Over/Under is a wager based on how many points you think will be scored in a specific game. Oddsmakers set the total, and bettors decide whether the final score will be higher or lower than that number. If an Over/Under is set at 44.5 points and you bet Over, you will need the combined score of both teams to be 45 points or higher to win your bet.

What is a Moneyline Bet?

A moneyline bet involves choosing which team you believe will win a specific matchup. The moneyline favorite carries a minus designation, like -130. This means that you need to wager $130 to earn a $100 profit. Conversely, the underdog carries a plus designation, like +110. This means that you win $110 in profit on a $100 bet.

Prop Bet Analyzer: View top rated props and historical prop performance by player >>

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