Early NFL Best Bets & Trends for Week 5 (2026)
Week 4 was an exciting one in the NFL. Let’s find some early NFL best bets for Week 5 using intriguing, favorable trends.
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Early Week 4 NFL Best Bets & Trends
(Odds courtesy of DraftKings Sportsbook)
Indianapolis Colts vs. Pittsburgh Steelers
While the Steelers played on Thursday night, the Indianapolis Colts played in London. Not only do the Steelers get extra days of rest, but they also got to stay in the United States of America. They’ll be home, while the Colts have to stay on the road for this one.
Pittsburgh has traded wins and losses this season. They’ve beaten the Falcons and Bengals but lost to the Patriots and Browns. Either way, it’s been a one-score game in three of those four games. The Steelers will be competitive.
On the flip side, the Colts have back-to-back wins over the Texans and Commanders. They’ve ultimately lucked out with injuries against their opponents. That said, the Colts are still dealing with injuries, especially at wide receiver, including Alec Pierce.
The Colts have also been terrible as a secondary and have struggled defensively against the run. The Steelers should be able to take advantage behind Aaron Rodgers. Plus, the Steelers’ two wins both came at home.
Pittsburgh is now 4-0 against the spread (ATS) in their last four games following a straight-up loss. Rodgers typically responds in these moments.
Back the Steelers at -2.5 (-110).
Pick: Steelers -2.5 (-110)
Detroit Lions vs. Arizona Cardinals
The Lions have been really poor on defense to begin the season. Their secondary has been Swiss cheese, leading to another Sunday Night Football loss to the Carolina Panthers. They’ve made Geno Smith and Bryce Young look like Hall of Fame quarterbacks in the last two weeks.
What’s stopping Jacoby Brissett from doing the same?
The Cardinals aren’t the greatest offense this season, but the pieces are coming together. Marvin Harrison Jr. even scored a touchdown in Week 4, and Michael Wilson/Trey McBride continue to be solid receiving options for the Cardinals’ offense.
I’d expect this game to be another tight shootout. So far, the Lions are 0-2 on the road this season. They’ve also allowed 31.75 points per game. Arizona has given up 29.25 points per game, so it’s going to be a fun one.
Anyway, the Lions are 0-7 ATS in their last seven games, after allowing more than 250 passing yards in their previous game. Let’s take the Cardinals at +4.5 (-115).
Pick: Cardinals +4.5 (-115)