MLB NRFI Picks & Bets: Reds vs. Guardians (Wednesday)
The 2025 MLB season continues on Wednesday with all 30 teams in action. Several entertaining games are scheduled, including a National League collision between the Los Angeles Dodgers and San Diego Padres. A battle between the New York Yankees and Kansas City Royals will surely draw attention on the American League side.
Sports bettors wanting to get in on the action without sweating through an entire nine-inning contest can turn to MLB No Runs First Inning (NRFI) tickets for a quick result. Here's a peek at two MLB NRFI picks and bets for Reds vs. Guardians.
- MLB NRFI/YRFI Cheat Sheet – Team View
- MLB NRFI/YRFI Cheat Sheet – Matchup View
- MLB Prop Bet Cheat Sheet
- MLB Consensus Odds
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Wednesday’s Best MLB NRFI Picks: Reds vs. Guardians
(Odds courtesy of FanDuel Sportsbook)
Cincinnati Reds (+100) at Cleveland Guardians (-118) NRFI Picks & Bets
Starting Pitchers: Nick Lodolo vs. Logan Allen
The Reds will aim to complete a sweep over the Guardians when they visit Progressive Field on Wednesday. It’s a meeting of southpaws as Cincinnati’s Nick Lodolo (4-4, 3.21 ERA) and Cleveland’s Logan Allen (3-4, 4.42 ERA) take the mound. It’s worth mentioning that the Reds and Guardians both sit among the bottom 10 squads in batting average, OPS, and home runs versus left-handed pitching. Early offense should not be expected.
Allen is one of just seven MLB pitchers to boast a first-inning ERA under 1.00 in 2025 (minimum of 11 starts). The third-year pro has held the opposing team to a .227/.292/.303 slash line through the opening 25 pitches of his outings. Those statistics have played a crucial role in Cleveland being a part of 43 scoreless first innings this campaign. That is tied with the Kansas City Royals for the highest total in the league.
On the other side, Lodolo has exited the first inning unscathed in five of his seven road starts. Overall, the former first-round pick has posted an impressive 0.85 WHIP and tallied 39 strikeouts in 43.1 innings away from Cincinnati. I like Lodolo to stay hot, considering the Guardians check in 25th in OPS and 27th in runs scored during the first inning. Commanding the strike zone will be his key to success in this showdown.
Pick: NRFI (-125)