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NFL Week 10 Same Game Parlays & Picks (2025)

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NFL Week 10 is here, and it’s time to lock in some best bets and props before the games kick off. Picking matchups against the spread (ATS) and betting on the over/under is more commonplace, but a same-game parlay (SGP) gives us even more added action. Let’s find some plus-money NFL Week 10 same-game parlays for every game on the Sunday afternoon slate.

Keep in mind the odds below are accurate as of writing, but are always subject to change up until kickoff. Keep track of any of the latest NFL injury news and odds movement before locking in any of these SGP bets. Without further ado, let’s dive into the best NFL Week 10 same-game parlay bets.

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Best NFL Week 10 Same Game Parlays 

(Odds courtesy of DraftKings Sportsbook unless otherwise noted)

Boost your NFL betting strategy with our Same-Game Parlay (SGP) Tool. Get expert correlations, projections and bet ratings.

New York Giants at Chicago Bears

    Caleb Williams has thrown for 280+ yards in back-to-back games coming into this matchup. Yet, we're fading him this weekend for a few reasons. First, the Bears could lean more on the ground game with the Giants struggling mightily to stop the run (more on that later). Plus, Kyle Monangai's emergence has given Chicago a real 1-2 punch in the backfield to take pressure off of Williams. 

    We also have some iffy weather conditions in the Chicago forecast for Sunday. There's a 65% chance of rain with swirling winds of 20 miles per hour (MPH) expected at Soldier Field during game time. That points to a run-heavy scheme from the Bears' offense, anyway. It's also worth noting that before these past two outbursts, Williams had fewer than 220 yards in four of the prior six games. 

    While we're fading the Bears' passing attack, let's back the run game with a D'Andre Swift prop. Swift returned to practice and is expected to play after missing last week with a groin injury. It's a great matchup as the Giants are allowing a league-high 5.5 yards per carry while giving up 150 rushing yards per game (second-worst in the NFL). Though Monangai has come on strong lately, Swift still had a pair of 100-yard games before his injury. 

    On the Giants' side of things, their run game can also have success. The Bears have a subpar rush defense, allowing 131.1 rushing yards per game (eighth-worst in the NFL) and 5.1 yards per carry (fourth-worst). Devin Singletary was the hot hand last week, but Tyrone Tracy Jr. is still the first man up in the Giants’ backfield with Cam Skattebo sidelined. Expect a bounce-back effort for Tracy, who was held to just 18 yards last week. 

    Parlay Odds: +440

    Buffalo Bills at Miami Dolphins 

      It's been profitable to fade the Dolphins' porous rush defense all season, and we'll gladly do it again this week with James Cook. Miami is allowing the third-most rushing yards per game this season (145.6), while giving up five yards per carry (fifth-most in the NFL). It's an ideal spot for Cook, who had 108 yards in this matchup earlier this year. Cook is also averaging 117.6 rush yards per game over the past seven contests, with 80+ yards in six of those seven. 

      Let's target another key contributor to Buffalo's offense this week. The Dolphins are allowing the fifth-most receiving yards per game to tight ends. Enter Dalton Kincaid, who has 100+ yards and six receptions in two of the last three games. His production has been up and down this year, but the arrow is pointing up. Notably, Kincaid had 66 yards on five catches against Miami earlier this season. 

      De'Von Achane's pass-catching ability is well-documented to this point. Yet, we're fading him in this week's matchup. The Bills are giving up the second-fewest receiving yards per game to running backs. Achane had 29 receiving yards versus Buffalo earlier this season, but he also needed seven catches to get to that number. Expect the Bills to key in on Achane in the passing game, especially since Miami lacks playmakers overall. This receiving yards line is a tick too high, considering Achane has failed to exceed 30.5 receiving yards in seven out of nine games. 

      Parlay Odds: +420

      Baltimore Ravens at Minnesota Vikings

        Baltimore's season is starting to turn around, with back-to-back double-digit wins coming into this week. The Ravens' offense returned to its usual elite form a week ago with Lamar Jackson back healthy. He threw for four touchdowns and posted a 78.3% completion rate in the blowout win over Miami. Plus, Derrick Henry racked up 119 rushing yards while clearly benefiting from Jackson's return. 

        Meanwhile, Minnesota is in a prime letdown/lookahead sandwich spot this week. The Vikings are coming off a big road divisional upset win over Detroit. They then face a pair of NFC North opponents in the next two weeks (Bears and Packers). It would be understandable if the Vikings have a down effort against a hungry Baltimore team that also has the rest advantage, after playing last Thursday. 

        Let's back Baltimore on the alt spread to win by at least a field goal. Notably, multiple betting trends are favoring the Ravens here. With Jackson at quarterback, the Ravens are 8-2 straight up (SU)/against the spread (ATS) with extra rest on the road over the years. Lamar is also 24-3 SU in his career against NFC opponents. On the flip side, the Vikings under Kevin O'Connell are 0-5 ATS in games directly after facing the Lions. 

        As for Jackson, let's back his rushing yards prop this week. Jackson only ran for 14 yards last game in his return from injury, but he should start to use his legs more moving forward as he gets healthier. The Vikings have only faced a few dual-threat quarterbacks this season. In two of those matchups, they allowed 58 rush yards to Caleb Williams and 62 yards to Justin Herbert just last week. Jackson tends to run more on the road as well, averaging 63.9 rush yards per game on the road last season. 

        Zay Flowers has been producing this year, whether or not Jackson is playing. The Ravens' top wideout is averaging a solid 68.8 receiving yards per game with 60+ yards in six out of eight contests. With Jackson under center, Flowers' production increases to 73.8 yards per game with 70+ yards in three out of five contests. 

        Parlay Odds: +455

        Cleveland Browns at New York Jets 

          Quinshon Judkins is good to go after the bye despite dealing with a shoulder injury. That means we can fire up his rushing yards prop in a favorable spot this week. The Jets are allowing the seventh-most rushing yards per game this season. That was before New York's rush defense just took a hit with stud defensive tackle Quinnen Williams traded away this week. 

          It's an ideal spot for Judkins to rack up yards. The rookie had 80+ rushing yards in four of his previous five games before suffering the shoulder injury last time out. Expect a heavy dose of carries for Cleveland's lead back as the offense leans on the run to take pressure off Dillon Gabriel on the road. 

          Speaking of Gabriel, he loves throwing to his tight ends. Harold Fannin Jr. has been the headliner in the Browns' tight end room lately, but David Njoku is still hanging around. The veteran could be involved more moving forward now that he has stuck around after the trade deadline. In three games with Gabriel at quarterback, Njoku has receiving totals of 67, 28 and 37 yards. He can go over 32.5 yards this week with just a few catches. 

          On the Jets' side of things, let's fade Breece Hall as a receiver. The Browns are allowing a league-low 18 receiving yards per game to running backs. Meanwhile, Hall has been held under 15 receiving yards in three straight games and in four of the last seven. New York is using Isaiah Davis as the pass-catching back and on third downs more often than Hall right now, which caps the latter's receiving usage anyway. 

          Parlay Odds: +470

          New England Patriots at Tampa Bay Buccaneers

            Drake Maye is putting together an impressive second season with New England as a dark-horse MVP candidate. Let's back his rushing yards prop this week. The Buccaneers are allowing the fourth-most rushing yards per game to opposing quarterbacks. The defense has also faced just a few running quarterbacks thus far. In those matchups, Tampa allowed 62 yards to Jalen Hurts, 48 yards to Tyrod Taylor and 27 yards to C.J. Stroud. 

            As for Maye, he's been running more lately. He is averaging 40 rushing yards and eight rush attempts over the past four games. Maye is also averaging a solid 30 rush yards per game overall this season, with at least 28 yards in five of the last eight contests. Since the Bucs' defense has struggled to contain dual-threat passers, Maye should be on the higher end of those averages this week. 

            Tampa Bay's offense will again be without Chris Godwin this week. That means Cade Otton should continue to be involved in the passing attack. He is averaging 59.3 receiving yards and five receptions over the past four games. Otton and Emeka Egbuka are the headliners in this receiving corps right now, and Baker Mayfield is loving his tight end lately. Meanwhile, the Patriots are allowing 63.6 receiving yards per game to tight ends (ninth-most in the NFL). 

            Bucky Irving is also sidelined for Tampa again. Even with Rachaad White in another expanded role, his rushing yards should be capped in a tough matchup. The Patriots are allowing a league-low 53.8 rush yards per game to opposing backs. The defense has also yet to allow 50 yards to a lead running back this year. Plus, despite the increase in carries lately, White is averaging just 44.8 rush yards over the past four games. Furthermore, the Bucs may use Sean Tucker to spell White again this week. 

            Parlay Odds: +459 (FanDuel Sportsbook)

            New Orleans Saints at Carolina Panthers

              After a brief respite, Rico Dowdle returned to his elite production last week. The Panthers gave him 25 carries, and Dowdle responded with a 130-yard explosion. He's established himself as the lead back over Chuba Hubbard, despite the latter now back from injury. Last week, Dowdle logged 72% of the snaps compared to just 22% for Hubbard. That was also after losing the snaps snare battle to Hubbard in the previous two games. 

              Dowdle's production cannot be ignored at this point. When he gets more than 10 carries in a game, the Carolina back has put up 206, 183, 79 and 130 rushing yards. Another big performance could be coming this week. The Saints are allowing the sixth-most rushing yards per game to running backs. If the Panthers do the right thing and give Dowdle the workload he deserves, 80+ yards is very attainable in this favorable matchup. 

              On the Saints' side of things, let's target a pair of receiving props now that Rashid Shaheed has been traded away. The trade should immediately open up playing time for Devaughn Vele. The wideout only has 39 yards on five receptions for the whole season, yet his snaps and role are bound to increase right away. Saints head coach Kellen Moore even said this week that Vele will be "very involved" now. He can get to 20+ yards on one or two catches.

              Sticking with the New Orleans offense, Juwan Johnson should also see more targets with Shaheed gone. The Saints tight end is averaging 44.3 receiving yards per game with up-and-down production. Moving forward, he can be a safe option for rookie quarterback Tyler Shough. The Panthers, meanwhile, are allowing the seventh-most receiving yards per game to tight ends and rank dead last in DVOA (defense-adjusted value over average) against tight ends. 

              Parlay Odds: +416 (FanDuel Sportsbook)

              Jacksonville Jaguars at Houston Texans 

                The Texans will start Davis Mills at quarterback with C.J. Stroud out with a concussion. While this does downgrade the offense overall, there are still some Houston player props to consider with Mills under center. Let's target two to kick off this parlay. 

                The Jaguars are allowing 75 receiving yards per game to tight ends, the second-most in the NFL. That immediately points to Texans tight end Dalton Schultz. He had a team-high 77 receiving yards on six catches last week after Mills played the majority of the game. Mills looked his tight end's way plenty, and that should continue in this week's matchup. For what it's worth, Schultz had 61 yards on eight receptions in a 2023 game where Mills entered in relief. 

                With Stroud out, Houston could also try to lean on the run more and take pressure off Mills. That brings us to Woody Marks. He might be in a bigger role than normal this week with Nick Chubb limited or out with his foot injury. Marks has been eating into Chubb's workload over the past month, anyway. He's seen double-digit carries in four of the last five games. 

                The Jaguars have a strong run defense, allowing the third-fewest rushing yards per game. Still, Marks can get to 35+ rush yards with the larger workload. That's especially true if Chubb is out or limited. Marks put up 62 and 69 yards in two recent games when getting more carries. 

                On the Jacksonville side of things, the arrow is pointing up for Parker Washington. The Travis Hunter injury has opened the door for Washington as the starting slot receiver. In turn, he had 90 yards on eight catches and nine targets last week in the bigger role. Washington also had 52 yards on 10 targets in the game before. Let's just hope newcomer Jakobi Meyers doesn't steal away targets and snaps now. 

                Parlay Odds: +435

                Arizona Cardinals at Seattle Seahawks 

                  The Cardinals have officially named Jacoby Brissett the starting quarterback this week over Kyler Murray. That's especially good news for Trey McBride. The tight end has 72, 74 and 55 receiving yards in the past three games with Brissett at quarterback. He's also seen 11 targets per game in this stretch. McBride now faces a Seahawks defense allowing 63.8 receiving yards per game to tight ends, the eighth-most in the NFL. 

                  Let's also back Brissett to throw it a ton this week. Ideally, he should play with more confidence after being named the starter, especially after leading the team to an upset win over Dallas on Monday night. The Seahawks are allowing the fourth-most pass attempts per game, at 37.3 per contest. Brissett has chucked it 44, 36 and 31 times in his three starts so far. Those 31 attempts last week could've been even higher, but the Cardinals had a second-half lead and turned to the run. 

                  The Arizona offense should also be more pass-centric this week because of the strong Seattle run defense. The Seahawks are allowing just 63.1 rush yards per game and 3.2 yards per carry to opposing running backs, the second-best marks in the league. The Cardinals are also road underdogs of nearly a touchdown, so it'll likely be a positive game script for Brissett to throw it plenty. 

                  Conversely, this matchup and game flow should cap Zonovan Knight's rushing yards. Again, Seattle's rush defense has been tough on opposing backs this year. Then there's this fact. Last week, Knight was held to just 27 yards on nine carries despite facing a poor Dallas defense. Yet, Emari Demercado racked up 79 yards on 14 carries in his return from injury. Arizona should use Demercado as the lead back again on early downs, while Knight is limited to goal-line and third-down situations. 

                  Parlay Odds: +405

                  Los Angeles Rams at San Francisco 49ers 

                    Puka Nacua returned from injury last week and immediately produced again. The Rams star wideout finished with 95 yards on seven receptions as Matthew Stafford went right back to him often. Nacua is now averaging 113.8 receiving yards and 9.8 receptions in his six full games played this year. 

                    The matchup is also a favorable one, as the 49ers have struggled to defend slot receivers. Look for Stafford to target Nacua enough for him to get 80+ yards, something the latter has done in all six healthy games this season. Plus, Nacua has had good games against San Fran over the years. Here are his yardage totals in four career matchups versus the Niners: 85, 97, 41 and 147. 

                    As for the San Francisco offense, let's fade the two stars. Christian McCaffrey might go off again as a pass-catcher, but his rushing should be capped in this matchup. The Rams are allowing the seventh-fewest rushing yards per game to running backs this season. McCaffrey has been held to fewer than 60 rush yards in six of the last eight games. He also only had 57 yards on 22 carries in the first meeting against the Rams this season.

                    The Rams have also been good at defending passes over the middle this season. In turn, they're allowing the sixth-fewest receiving yards per game to tight ends. Look for George Kittle's yards to be limited in this matchup. The star tight end is only averaging 25 yards per game with fewer than 45 in each. Plus, Kittle is averaging just 34.4 yards per game in his last seven matchups against Los Angeles. 

                    Parlay Odds: +420

                    Detroit Lions at Washington Commanders 

                      The Lions are favored by more than a touchdown on the road at Washington this week. Let's take the alternate spread and just bank on Detroit winning by a touchdown or more. Dan Campbell's squad will be poised to bounce back after losing to Minnesota last week. Plus, it's a classic revenge spot for the Lions. 

                      First off, backing the Lions off a loss has been very profitable. Detroit has won and covered 12 straight games after losing the previous week. With Campbell and Jared Goff in town, Detroit is also 21-8 ATS off a straight-up loss. Then we have the revenge angle. After losing to Washington in the playoffs last year, the Lions will be primed to return the favor. Plus, it comes against a struggling and banged-up Commanders team. 

                      En route to the win, Amon-Ra St. Brown should produce in a favorable matchup. The Commanders are allowing the second-most receiving yards per game to opposing wide receivers, at 171.3 per game. The secondary is also dealing with multiple injuries and just placed Marshon Lattimore on injured reserve (IR). St. Brown is averaging 79.4 yards per game with at least 86 in three of the last four. 

                      On the Washington side of things, Marcus Mariota is back at quarterback with Jayden Daniels dislocating his elbow last week. The go-to prop for Mariota is his rushing yards. He's averaging 30.5 rush yards in his four meaningful games played this year. Last season, he ran for 56 and 34 yards in two relief appearances. Mariota knows how and when to use his legs in the right situation, and 25+ rushing yards is a low bar for him. 

                      The Lions are allowing just 18.3 rush yards per game to opposing quarterbacks, but they've also only faced a handful of true dual-threat options. In those matchups, Detroit gave up 32 rushing yards to Patrick Mahomes, 35 yards to Lamar Jackson and 27 yards to Caleb Williams. Mariota, meanwhile, is averaging 36.9 rushing yards over his past seven games of legit snaps. He also averaged 33.6 rushing yards in 13 games as the starter for Atlanta in 2022. 

                      Parlay Odds: +440



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