NFL Week 12 Early Odds, Picks & Predictions: Saints vs. 49ers (2022)

For the past few NFL seasons, each Sunday night I’ve written an early bets piece highlighting some applicable trends I’ve noticed for the upcoming week.

I’m not a trends bettor, but I find that historical situational data helps me identify spots I should consider further when analyzing games.

So here are some trends for Week 12 as well as an early bet I like for Saints vs. 49ers based on the current lines in the market and my early personal projections, which I will update throughout the week along with our premium BettingPros spread projections.

Prop Bet Analyzer: View top rated props and historical prop performance by player >>

NFL Week 12 Early Odds, Picks & Predictions: Saints vs. 49ers

Check out our Saints at 49ers matchup page.

  • Kickoff: Sunday, Nov. 27, 2022, 4:25 pm ET
  • Location: Levi’s Stadium
  • Consensus Spread: Saints +8.5

Saints at 49ers: 2022 ATS Records

  • Saints ATS: 4-7 (-30.4% ROI)
  • 49ers ATS: 4-5 (-15.3% ROI) – before 49ers play Week 11 MNF

New Orleans Saints Trends

  • QB Andy Dalton: 42-33-2 ATS (10.2% ROI) as underdog
  • QB Andy Dalton: 4-4 ATS (-4.4% ROI) in 2022

San Francisco 49ers Trends

  • HC Kyle Shanahan: 17-28-1 ATS (19.3% ROI for faders) as favorite
  • HC Kyle Shanahan: 16-24-1 ATS (15.8% ROI for faders) at home
  • HC Kyle Shanahan: 8-16-1 ATS (26.9% ROI for faders) as home favorite

Saints at 49ers: Early Bet

  • Best Line: Saints +8.5 (-110, BetMGM)
  • Early Projection: Saints +7.25

Note: I first posted this pick in the BettingPros app via the early line of +8.5.

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