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NFL Week 16 Same Game Parlays & Picks (2025)

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NFL Week 16 is here, and it’s time to lock in some best bets and props before the games kick off. Picking matchups against the spread (ATS) and betting on the over/under is more commonplace, but a same-game parlay (SGP) gives us even more added action. Let’s find some plus-money NFL Week 16 same-game parlays for every game on the Sunday afternoon slate.

Keep in mind that the odds below are accurate as of writing, but are always subject to change up until kick-off. Keep track of any of the latest NFL injury news and odds movement before locking in any of these SGP bets. Without further ado, let’s dive into the best NFL Week 16 same-game parlay bets.

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Best NFL Week 16 Same Game Parlays 

(Odds courtesy of DraftKings Sportsbook)

Boost your NFL betting strategy with our Same-Game Parlay (SGP) Tool. Get expert correlations, projections and bet ratings.

Buffalo Bills at Cleveland Browns 

    Buffalo is coming off a big road win at New England and faces the lowly Browns. This should be a comfortable victory for the Bills, as double-digit favorites, which would cap Josh Allen's passing yards. It's always risky taking the under on a prop for someone like Allen, but the offense likely leans on the ground game in the second half with a lead. Plus, some trends are pointing to the under, in addition to presumed game flow. 

    Cleveland boasts a strong pass defense, allowing just 189.6 passing yards per game to opposing quarterbacks (second-fewest in the NFL). Quarterbacks are also averaging only 27.7 pass attempts against this defense (third-fewest). Meanwhile, Allen is averaging 195.1 yards per game on the road this year, with fewer than 200 in five of the seven contests. He's also averaging only 195.5 yards per game in the Bills' six double-digit wins this season. 

    For the Browns, look for Quinshon Judkins to be productive on the ground. The rookie just had two of his worst games of the year, with 26 and 21 rushing yards in back-to-back weeks. That's not ideal, but this week's matchup is too good to pass up. The Bills are allowing 115.1 rushing yards per game to opposing running backs, the third-most in the NFL. Before his last two duds, Judkins was averaging 68.9 rushing yards over the first 11 games with at least 59 in eight of those games. 

    Browns tight end Harold Fannin Jr. might be more limited than usual this week. Buffalo is among the best in the league at covering tight ends, giving up just 32.8 yards per game to the position (second-fewest in the NFL). The defense is also allowing a league-low 2.71 receptions per game to tight ends. Yes, Fannin has been targeted heavily by Shedeur Sanders, and he just went off for 114 yards two games ago. However, he's also been held to fewer than 50 yards in 10 out of 14 games overall this year.

    Parlay Odds: +485

    Los Angeles Chargers at Dallas Cowboys 

      Justin Herbert's passing yards have been way down lately, averaging just 145.3 yards over the past four games. However, each performance deserves some context. The last two came against tough defenses in Philadelphia and Kansas City. He also didn't need to throw much in a comfortable win over Las Vegas, where the Chargers ran it 43 times. The rough showing in a blowout loss to Jacksonville wasn't great, but he did exit early with an injury. 

      Yes, the Chargers quarterback continues to deal with that non-throwing hand injury. Also, his recent form isn't ideal. However, this week presents a prime bounce-back opportunity. The Cowboys are allowing a league-high 270.9 passing yards per game to opposing quarterbacks. The secondary has also given up at least 245 yards to quarterbacks in six of the last seven games. Herbert was averaging 265.6 yards per game over the first nine games of the season, and he can get back to that production here. 

      As Herbert rebounds, let's also count on Ladd McConkey to bounce back. The Chargers' wideout has been quiet lately, with fewer than 40 yards in four straight games. Before that, though, he averaged 83.6 yards per game over the previous five contests. It's only a matter of time until McConkey returns to that level. He faces a poor Dallas secondary allowing the third-most receiving yards per game to wide receivers. The unit has also struggled against slot-type pass-catchers. 

      On the Cowboys' side, Jake Ferguson will face a Chargers defense that's had issues against tight ends recently. They allowed seven catches for 70 yards to Travis Kelce last week, eight catches for 78 yards to Dallas Goedert the game prior and 63 yards with two scores to Brock Bowers before that. Ferguson is averaging 40.7 receiving yards per game this year, and he can be on the higher end of that this week. He's also gone over 35.5 yards in four of the last six games.

      Parlay Odds: +415

      Kansas City Chiefs at Tennessee Titans 

        After last week's loss, the Chiefs are now eliminated from playoff contention. To make matters worse, Patrick Mahomes is out for the season after tearing his ACL. Both are big blows to the defending AFC champs, and it's safe to wonder what the mindset and motivation will be like for this team. As you'll notice in this parlay, though, we're banking on Andy Reid having his team ready to bounce back and finish the season strong. 

        Gardner Minshew now takes over at quarterback with Mahomes sidelined. While it's an obvious downgrade, Travis Kelce can still be productive in a featured role. This could be Kelce's final season before a possible retirement. Kansas City will likely want him to be heavily involved over the final few games, especially without a playoff berth to worry about, and Minshew can lean on his veteran tight end. Tennessee is allowing a league-average 54.5 receiving yards per game to the tight end position. Lately, though, defending tight ends has been a problem for the Titans. They gave up 88 yards to George Kittle last week and 114 yards to Harold Fannin Jr. the game prior. 

        Last year with the Raiders, Minshew loved throwing to his tight end. In the quarterback's 10 games, Brock Bowers averaged 67.3 yards and 8.9 targets per game. Of course, it was a different situation and not apples-to-apples. Still, the point remains that Minshew can rely on a trustworthy tight end at this stage in his career. As for Kelce, getting to 40+ yards is a low bar for a player averaging 56.9 yards per game this season with 40+ yards in 12 out of 14 contests. 

        With Minshew under center, the Chiefs will also likely lean on the run game. That should include Isiah Pacheco in a rising role. Since Pacheco returned from injury in Week 13, he's seen his snap share and carries increase in three straight games. That culminated with 46% of the snaps with 11 carries last week. He only gained 21 yards on those attempts, but the bigger role is notable. Conversely, Kareem Hunt has seen his carries and snaps decrease for three straight games with Pacheco active. The former only saw six rush attempts last week. 

        If we consider that Pacheco will get more work than normal, his rushing yards line this week is low. He's averaging 36 rushing yards per contest amid his lower-volume role thus far. When Pacheco has gotten double-digit carries, though, he's averaged 42.3 yards per game in the six instances. He now faces a Titans defense allowing 4.4 yards per carry (12th-most in the NFL) and 123.6 rushing yards per game (13th). 

        On the other side, Tony Pollard's rushing yards should be capped in a tough matchup. The Chiefs are giving up only 77.3 rushing yards per game to opposing running backs this year, which is the sixth-fewest in the league. Pollard could come back down to Earth after rushing for 100+ yards in two straight games. Before that, he was averaging just 49.5 yards per game over the first 12 games of the season. 

        Parlay Odds: +435

        Cincinnati Bengals at Miami Dolphins 

          The Dolphins are now turning to rookie Quinn Ewers at quarterback after benching Tua Tagovailoa. While that certainly creates some uncertainty, we're still targeting a couple of Miami pass-catchers in this week's favorable matchup. The Dolphins will want Ewers to be as comfortable as possible, so that means designing quick and easy completions to the tight end and running back in the passing game. 

          Let's start with Darren Waller. As you're likely well aware, the Bengals are terrible at covering tight ends. They're allowing a league-high 91.1 receiving yards and 7.1 receptions per game to the position. Opposing tight ends regularly have productive games in this matchup, and Waller should be the next. He just had his best game of the year last week with 66 yards and two scores on seven catches. Waller has at least 25 yards in four of his six full games with Miami, averaging 40.5 yards per game in those contests. 

          De'Von Achane should also be productive in the passing attack as Miami dials up check-downs and screens for their stud tailback. The Bengals are allowing the third-most receiving yards per game to running backs (45.6 per contest). That plays right into our narrative. Achane, meanwhile, has at least 39 receiving yards in four of the last six games while averaging 32.1 receiving yards per game this season overall. He just had six catches for 67 yards last week, and his role as a pass-catching back should continue in this matchup with Ewers at quarterback. 

          As for the other running back in this game, Chase Brown can put together a good overall performance with his combined rushing and receiving yards. The Dolphins are giving up 106.4 rushing yards and 37.1 receiving yards per game to opposing running backs, which are both bottom-10 ranks in the league. Brown is averaging 101.5 total yards over his last eight games, with 90+ yards in seven of those. Even with Joe Burrow back under center, Brown had 113 and 90 total yards in two of the three weeks. 

          Parlay Odds: +405

          New York Jets at New Orleans Saints 

            Have the Saints found their new franchise quarterback in Tyler Shough? The rookie has now led New Orleans to two straight upset wins over division opponents, and he's made the offense much more competitive. Shough's running ability has been particularly encouraging. He's totaled 127 rushing yards over the past four games, with 55 and 32 in the past two weeks. Let's count on Shough using his legs yet again this week. The Jets just allowed 51 rush yards to Trevor Lawrence last week. 

            The other big headline for the Saints, at least for fantasy and player props, is their running back situation. Alvin Kamara remains out, and Devin Neal is now on injured reserve (IR). It's now Audric Estime and Evan Hull manning the backfield. The two basically split snaps and carries last week, so it's anyone's best guess as to who leads the way. 

            Let's take a stand on Estime. He's the more proven back in the pro ranks than Hull at this point. As a rookie with Denver last year, Estime had 310 rushing yards on 76 carries in a backup role. When he saw nine or more carries in four different games, he averaged 39.8 yards per game. If we assume he gets close to that workload (or more), then 30+ yards is very attainable in this matchup. The Jets are allowing 137.2 rushing yards per game (fourth-most in the NFL). 

            On the New York side, Adonai Mitchell has established himself as the team's top wideout. He's averaging eight targets per game in his five contests with the Jets. After going for 58 yards last week, Mitchell is also now averaging 56.5 yards per game over the last four weeks. That includes 40+ yards in three of those four games. His six receptions on nine targets last game are also encouraging that Brady Cook should continue to look his way. 

            Parlay Odds: +430

            Minnesota Vikings at New York Giants 

              The over on Jaxson Dart's rushing yards prop continues to be a profitable pick. The Giants' rookie quarterback has run for 50+ yards in six of his nine starts while averaging 44.4 rush yards per game. Dart uses his legs and athleticism to make plays, especially when the pocket collapses. That could be an often-occurrence this week as the Vikings blitz at a league-high rate. Dart could be scrambling more than usual, which points us to his rushing yards, in addition to how productive he's been as a runner. 

              Tyrone Tracy Jr. can also rack up rushing yards in this matchup. Minnesota is giving up 107 rushing yards per game to opposing running backs, the eighth-most in the league. The defense has also allowed 90+ rush yards to a running back in three of the last five games. As for Tracy, he's averaging 65.4 rushing yards and 15.6 carries over the past five games while operating in the lead-back role. That includes 60+ yards in four of the last five contests. 

              A Minnesota running back can have a solid game, too. The Giants are giving up a league-high 5.6 yards per carry while allowing 153.6 rushing yards per game (second-most). That leads us to Aaron Jones, who's been the more productive ball-carrier with slightly more carries than Jordan Mason lately. Jones has 110 rushing yards and 26 carries over the past two games. He's also now averaging 57.7 rush yards when seeing nine or more carries in a game (six instances). 

              Parlay Odds: +440

              Tampa Bay Buccaneers at Carolina Panthers 

                Targeting running backs and their receiving yards has been a profitable prop all season long against Tampa Bay. Let's do it again this week with Rico Dowdle. The Buccaneers are allowing a league-high 55.9 receiving yards per game to opposing running backs. Meanwhile, Dowdle has been the better and more involved pass-catcher than Chuba Hubbard for Carolina. The former is averaging a decent 23.9 receiving yards over the past 10 games, with over 15.5 yards in six of those games. He had just five receiving yards last week, but put up 55, 36 and 21 in the three games prior.

                On the other side, Bucky Irving should get to 60+ rushing yards. Since returning from injury, he's stepped right back into the lead-back role for Tampa with 15+ carries in three straight games. Irving has 60+ rushing yards in five of his last six games, averaging 62.7 yards per game in this stretch. He should be on the higher end of that this week, as Carolina is allowing 101.7 rush yards per game to running backs this year (11th-most in the NFL). 

                Back to the Carolina offense as we back a rising contributor. Jalen Coker has carved out a solid role in the Panthers' wide receiver corps. He's averaging 54.5 receiving yards over the past four games, with 60 and 74 yards in the past two outings. Coker just led the offense in receiving last week, and his connection with Bryce Young has clearly strengthened. The Buccaneers have a below-average pass defense, so Coker can do just enough to clear his yardage prop.

                Parlay Odds: +445

                Jacksonville Jaguars at Denver Broncos 

                  The Jaguars boast arguably the best run defense in the NFL. They're allowing a league-low 66.6 rushing yards per game to opposing running backs. The defense also has yet to give up 75 rush yards to any running back this year. Though RJ Harvey has run for 75 and 65 yards in the past two games as Denver's lead back, he'll likely be quieted in this matchup. Let's take the under on his yardage prop as the Broncos may go with a more pass-heavy approach. 

                  On that note, bank on Bo Nix racking up pass attempts. Conversely, the Jags are allowing a league-high 37.4 pass attempts per game. Their strong rush defense regularly forces teams to the air more often. As for Nix, he's averaging 36.5 pass attempts over the past six games. He's also averaging 36 attempts per game this season overall. Denver trusts him to throw it around, and the matchup should dictate that this weekend. 

                  For the Jacksonville offense, we're looking at tight end Brenton Strange to step up. Pat Surtain and the strong Denver secondary could lock down Jakobi Meyers and Brian Thomas Jr. in the passing game. That would put Strange as a main target for Trevor Lawrence. That's been a theme for other teams facing the Broncos, as they're allowing the seventh-most receiving yards per game to tight ends (64.1 per contest). Strange is averaging 43.9 yards per game this season, and he can be on the higher end of that, considering the matchup. 

                  Parlay Odds: +480

                  Atlanta Falcons at Arizona Cardinals 

                    When it comes to the Cardinals, one prop continues to be profitable. That's Jacoby Brissett's passing attempts as we go right back to the well. The veteran quarterback is now averaging 42.8 pass attempts per game in his nine starts this year. That includes 40+ attempts in six straight games, averaging 45.7 attempts in this stretch. He'll now face an Atlanta defense allowing an average of 37.4 pass attempts over the past five weeks. 

                    On the Falcons' side, Kyle Pitts could be in line for another big game. The Falcons tight end just exploded for 166 yards and three touchdowns on 11 catches last week. He also had 90 and 82 yards in the two prior games. Kirk Cousins is looking Pitts' way often lately, as the latter has 12, 10 and eight targets in the past three games as well. At the time of this writing, his receiving yards prop wasn't available. You can consider the over on that, but we'll take a shot on Pitts finding the end zone again. 

                    Over the past five games, the Cardinals have given up five total touchdowns to the tight end spot. That includes at least one in four of the last five games. Arizona is also allowing 63.8 receiving yards per game to tight ends, seventh-most in the NFL. Before last week, Pitts only had one other touchdown this season. He's also infamously not scored much in his Falcons career. However, the matchup and his current form create some value if you want to take a chance. 

                    Let's also back the over on this game. The Falcons are 6-1 to the over in their last seven games, while the Cardinals are 8-2 to the over in their last 10 contests. Both defenses are below-average units, allowing a combined 52.1 total points this season. Atlanta has given up 27+ points in five of the last six games, while Arizona is allowing 36.2 points per game over the past six contests. 

                    Parlay Odds: +430

                    Pittsburgh Steelers at Detroit Lions 

                        After blowing a lead and losing a tight one in Los Angeles last week, the Lions look to bounce back at home. They've regularly responded well after a loss, especially on offense. The Lions are averaging 39.6 points per game following a loss this season, with at least 34 points in four of the five instances. They're also averaging 35.7 points per game after a loss in the past 10 such games. Take the over on Detroit's team total at home against an inconsistent Pittsburgh defense that's allowed 27.8 points per game in its last four road games. 

                        As we back the Lions to put up points, it should include a good Jared Goff performance. The Steelers are allowing 260.6 passing yards per game to opposing quarterbacks (fourth-most in the NFL), as well as 37 pass attempts per contest (third-most). Goff, meanwhile, is averaging 296.6 passing yards per game following a loss this season. He's also averaging 278.7 pass yds following a loss in the last 12 instances. 

                        We've also seen the Lions lean on Goff and the passing game more often lately. He's averaging 35.7 pass attempts and 291.6 passing yards over the past seven games. That includes at least 33 attempts in six of the last seven contests, and 270+ yards in five of the seven. The two outliers, by the way, saw Goff throw for 255 and 256 yards. So, putting it all together, getting to 32+ attempts and 260+ yards are lower bars for him right now. 

                        On the other side, look for DK Metcalf to have a solid outing. The Lions are allowing a league-high 172 receiving yards per game to opposing wideouts. Metcalf recently had some down games, but the connection with Aaron Rodgers has improved. The Steelers' top wideout had 148 yards on 12 targets against Baltimore two games ago, and then had 55 yards and a touchdown last week versus Miami. It hasn't been a great season for Metcalf, but he's still averaging a decent 57.7 yards per game with 50+ yards in seven out of 14 contests. 

                        Parlay Odds: +440

                        Las Vegas Raiders at Houston Texans 

                          The Raiders are averaging a league-low 14 points per game and just got shut out last week. Meanwhile, the Texans boast the NFL's top defense and allow just 16.3 points per game this year. Naturally, we're taking the over on the Las Vegas team total. It might be crazy, but the numbers say that the visitors can get to 10 points in what should be a blowout loss. 

                          Despite being as bad offensively as they are, the Raiders have actually scored at least 10 points in nine of 14 games this year. Plus, after being held to 10 points or fewer, Las Vegas is actually averaging 20.6 points per game in the following game (five instances). As for Houston, as good as the defense is, opposing teams have scored 10+ points in 12 out of 14 games against the Texans. Yes, we've yet to see this specific matchup. But maybe the Raiders get a slight boost on offense with Geno Smith trending towards returning. It's not great, but he at least brings a veteran presence. 

                          Alright, let's now focus on the Houston offense. It's looking like Nick Chubb will be the Texans' lead back this week with Woody Marks banged up. That means he has a great shot at reaching the end zone. The Raiders have allowed 19 rushing touchdowns through 14 games so far. They've also given up a rushing touchdown to an opposing lead back in four straight games entering this week. Even if Jawhar Jordan is involved, Chubb is the better goal-line back and should be in there on short-yardage carries near the end zone. 

                          Nico Collins can also put up numbers against the poor Las Vegas defense. The Texans' top wideout is averaging 77 receiving yards per game this year. He also has 75+ yards in six of the last seven games, averaging 94.6 yards per game in this stretch. Collins now faces a Raiders secondary that's allowing the 10th-most receiving yards per game to opposing wide receivers. Getting to 60+ yards is a low bar for him, as long as he gets there before Houston builds a big lead. 

                          Parlay Odds: +500

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