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NFL Week 2 Same Game Parlays & Picks (2025)

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NFL Week 2 is here, and it’s time to lock in some best bets and props before the games kick off. Picking matchups against the spread and betting on the over/under is more commonplace, but a Same-Game Parlay (SGP) gives us even more added action. Let’s find some plus-money NFL same game parlays for every game on the NFL Week 2 Sunday afternoon slate.

Keep in mind the odds below are accurate as of writing, but are always subject to change up until kick-off. Keep track of any of the latest NFL injury news and odds movement before locking in any of these SGP bets. Without further ado, let’s dive into the best NFL Week 2 same-game parlay bets.

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Best NFL Week 2 Same Game Parlay Bets 

(Odds courtesy of DraftKings Sportsbook unless noted otherwise)

Boost your NFL betting strategy with our Same-Game Parlay (SGP) Tool. Get expert correlations, projections and bet ratings.

Jacksonville Jaguars at Cincinnati Bengals 

    Let's go with a Jaguars-heavy parlay for their road matchup at Cincinnati. In Week 1, Jacksonville cruised to a 26-10 win over the Panthers after leading by 17 at halftime. The arrow is pointing up for an offense that looks rejuvenated under Liam Coen. Things were easy against a poor Carolina team, but another good showing could be in the cards against the Bengals here. 

    Last week, Cincy survived in a 17-16 victory over the Browns. There were warning signs everywhere, though. The Bengals put up just 141 total yards while allowing 327 to Cleveland. The Cincinnati run game managed only two yards per carry while Joe Burrow was held to 113 passing yards. The offense doesn't look in sync right now. 

    Slow starts have been a theme for the Bengals in recent years. After failing to cover in Week 1, they are now 3-8 against the spread (ATS) over the first two weeks of the season with Burrow at quarterback. That includes 0-6 ATS as favorites in the first two games. 

    Trevor Lawrence finished with just 178 passing yards in the opener. It's not ideal, but the Jags' passing game should be better this week. The offense leaned on the run in the second half with a big lead versus Carolina. Now Lawrence faces a Bengals defense that gave up 290 passing yards to Joe Flacco last week. We should see bigger yardage totals from Lawrence moving forward, considering the Buccaneers averaged 250.4 pass yards per game last year under Coen (third).

    One of Lawrence's favorite targets in Week 1 was tight end Brenton Strange. He had four catches for 59 yards, leading the team in receiving. Meanwhile, Cincinnati allowed the Browns’ tight end duo of David Njoku and Harold Fannin Jr. to combine for 10 catches and 100 yards last week. It's a favorable matchup, considering the Bengals also gave up the most receptions and third-most yards to tight ends in 2024.

    Parlay Odds: +315

    Los Angeles Rams at Tennessee Titans 

      Despite only scoring 14 points last week, the Rams showed some encouraging signs on offense in their victory over Houston. Matthew Stafford, after missing most of camp with an injury, went 21-of-29 through the air and posted a 109.1 passer rating. There was some rust, but the connection with Puka Nacua hasn't gone anywhere. 

      The Rams’ offense took a few drives to get going, which is understandable, especially against a talented Houston defense. Eventually, though, Stafford and Co. found a rhythm. The Rams went 7-for-13 on third downs and only had one turnover in the game, a fumble by tight end Colby Parkinson. Let's bank on the Los Angeles offense being better in Week 2. 

      Last week, Kyren Williams ran for 66 yards against Houston. He averaged only 3.7 yards per carry, but his 18 attempts are a great sign that he's still the clear lead back. Meanwhile, Blake Corum only had one carry. Yards should be easier to come by this week as Tennessee allowed 151 rushing yards and five yards per carry to Denver in the last game. Williams is due for more success after averaging 81.2 rushing yards per game in 2024.

      Cam Ward had a rough NFL debut against Denver. He had a poor 43% completion rate (12-of-28) with only 112 passing yards. The Titans rookie quarterback was also sacked six times. Also, notably, he didn't record a single carry last week. Ward should be willing to scramble and run it more at home in Week 2, especially since the Rams' pass rush can force him out of the pocket. Despite not running at all last game, Ward still has dual-threat ability.

      Parlay Odds: +340

      Buffalo Bills at New York Jets

        This is a potential letdown spot for Buffalo after pulling off last week's dramatic comeback win over Baltimore. The Bills improbably overcame a 15-point deficit with less than five minutes to go in the game. It was an emotional and monumental effort on Sunday Night Football. Now, they have to turn around and face the division-rival Jets on the road. 

        As for the Jets, they should be motivated after blowing a fourth-quarter lead of their own last week. New York probably should've beaten the Steelers, but a 60-yard field goal by Chris Boswell with a minute remaining was the dagger. The Jets should keep this game tight with a real shot at pulling an upset. 

        The Jets had a ton of success on the ground in Week 1. They ran for 182 yards on 4.7 yards per carry versus Pittsburgh, as Justin Fields and Breece Hall gelled together. Meanwhile, the Bills just got gashed on the ground for 238 yards on 8.2 yards per carry by Baltimore. They had trouble containing both Derrick Henry and Lamar Jackson. 

        Let's count on both Fields and Hall racking up yards like last week. Hall accounted for 145 total yards in the opener, including 107 rushing yards on 19 carries. Fields had 48 yards on 12 attempts. That Jets' tandem will be a problem for opposing defenses, and the Bills just showed how much they may struggle against good rushing teams with dual-threat quarterbacks. 

        Parlay Odds: +288

        New York Giants at Dallas Cowboys

        (Odds courtesy of BetMGM)

          The jury was mostly out on the Giants and Cowboys coming into this season. After one week, though, it's clear Dallas is the better team right now. It hung with the defending Super Bowl champion Eagles last week and even had opportunities to pull off the upset. The offense put up 20 points before halftime, and then stalled in the second half (no thanks to a lengthy weather delay). 

          On the flip side, the Giants mustered only six points and 231 total yards in their loss to Washington. Offensively, Russell Wilson had more incompletions (20) than completed passes (17) while the run game averaged just 3.2 yards per carry. New York’s defense, meanwhile, gave up 432 total yards to the Commanders. 

          The Cowboys are the play here. They should win comfortably based on what we just saw from both teams last week. Notably, Dak Prescott is 13-2 straight up (SU) and 10-5 ATS in his career against the Giants. That includes 13 straight victories against the division rivals. 

          After some uncertainty in the preseason, Javonte Williams looks like the clear lead back for Dallas. In Week 1, he saw the majority of work in the backfield with 15 carries for 54 yards and two touchdowns. Meanwhile, Miles Sanders had just four carries, and rookie Jaydon Blue was a healthy scratch. The Giants just allowed Washington to run for 220 yards on 6.9 yards per carry last week. Jacory Croskey-Merritt had 82 yards as the Commanders' leading rusher. 

          Despite how bad the Giants' offense looked last week, there were some bright spots. One was Wan'Dale Robinson, who saw eight targets and finished with 55 receiving yards on six catches. The Giants’ passing game was basically him and Malik Nabers, as Wilson seems to have some favorite options already. Robinson averaged 41.1 receiving yards per game last year, including 35+ yards in 12 out of 17 contests. 

          Parlay Odds: +360 

          Chicago Bears at Detroit Lions 

            It's bounce-back time for Detroit after losing to Green Bay in Week 1. The Lions, with Jared Goff at quarterback, have won and covered 10 straight games after a loss going back to the 2022 season. Meanwhile, Chicago just blew a double-digit fourth-quarter lead on Monday Night Football. Now, they have to turn around on a short week to face a second straight divisional opponent. 

            It's a tough spot for the Bears on the road. The Lions' defense, in particular, should respond after giving up 27 points to the Packers last week. The unit will be familiar with how to defend Ben Johnson's offense and limit Caleb Williams. On that note, the second-year signal-caller had a shaky season debut in Chicago's new offense. He went 21-fofr-35 through the air for just 210 yards. The Bears converted only three of their third-down attempts. 

            Then there's Chicago’s defense, which allowed 21 fourth-quarter points to Minnesota en route to last week's loss. That late collapse could carry over into this game. The Lions' offense is bound to wake up after a quiet season opener. 

            Expect Jahmyr Gibbs to have a larger role this week as well. He had just 50 total yards last game, and 31 of those came on 10 catches as the Lions trailed the whole time. This week should be a much more favorable game script for Gibbs, including a larger rushing workload. Gibbs had 104 and 154 total yards in two games against Chicago last year. Plus, the Bears allowed the second-most rushing yards to opposing running backs a season ago.

            On the Chicago side, look for Caleb Williams to use his legs. He did just that in Week 1 with 58 rushing yards on six attempts. His dual-threat ability is a real threat, and he should be more willing to run in this second pro season. Last year, Williams ran for 39 and 34 yards in his games versus Detroit, which allowed the fourth-most rush yards to opposing quarterbacks in 2024.

            Parlay Odds: +455

            New England Patriots at Miami Dolphins 

            (Odds courtesy of FanDuel Sportsbook)

              It doesn't get much worse than Miami's offensive showing in Week 1. The Dolphins scored just eight points with only 211 total yards. Although it is concerning, the offense is bound to wake up at home after that disaster. 

              The Dolphins averaged 24.8 points per game (PPG) at home last year, compared to 16.3 on the road. In 2023, they averaged 31.9 PPG at home. Meanwhile, the Patriots' defense looked vulnerable last week with 389 total yards and 20 points allowed to a rebuilding Raiders' offense. 

              Tua Tagovailoa has always played better in Miami, and he should be more connected with Tyreek Hill and Jaylen Waddle at home this weekend. New England allowed Geno Smith and the Raiders to throw for 362 yards last week. There's a clear upside for Tagovailoa to have much more success through the air after finishing with only 114 yards in Week 1. For what it's worth, he had 288 yards at home against Las Vegas a season ago.

              Let's also get some exposure to the Patriots' offense with rookie running back TreVeyon Henderson. The Dolphins' defense might be one of the worst in the NFL this season. Giving up 27 points and 418 total yards to the Colts last week is definitely worrisome. More specifically, Miami allowed 112 combined rushing yards to Indy's backfield tandem of Jonathan Taylor and DJ Giddens.

              Enter Henderson, who received plenty of preseason hype and should be a top playmaker in New England's offense this season. In Week 1, Henderson only logged 35% of the offensive snaps while Rhamondre Stevenson saw the majority of playing time in the backfield. Even so, Henderson saw 11 total touches on his 25 snaps in his NFL debut. In that limited usage, he still racked up a solid 51 total yards. The Patriots looked to get the ball in his hands when he was out there, and it shouldn't be long until they fully commit to him as the main guy over Stevenson. 

              Parlay Odds: +300 

              San Francisco 49ers at New Orleans Saints 

              (Odds courtesy of FanDuel Sportsbook)

                The total in this game has dropped over the week. That's largely due to San Francisco's slew of recent injuries. Brock Purdy is out and could miss multiple weeks, leaving Mac Jones as the starting quarterback. Plus, George Kittle was just placed on injured reserve (IR) after suffering a hamstring injury in Week 1. 

                The 49ers likely go with a run-heavy offensive game plan with Jones under center. They'll want to slow this game down while leaning on the defense and strong run game to get out with a win. Meanwhile, it's hard to get excited about the Saints' offense. Spencer Rattler looked shaky last week and now has to face a much tougher defense in San Fran. 

                As noted, the Niners' injury situation on offense is pretty bleak. The one main healthy option, though, is Christian McCaffrey. He should see all the touches he can handle right now. Last week, he recorded 22 carries for 69 yards and added nine catches for 73 yards. Another heavy workload is likely coming with Jones at quarterback, and the Niners' offense severely lacks playmakers outside of McCaffrey. 

                We targeted Juwan Johnson's receiving yards prop in last week's article, and it paid off. Let's go right back there with the number still too low. The tight end's eight receptions and 76 yards both led the Saints last week. He's a clear favorite target for Rattler, which should continue as long as the latter is under center. Johnson had 48+ yards in four of Rattler's six starts last year. 

                Parlay Odds: +552

                Seattle Seahawks at Pittsburgh Steelers 

                  The Steelers just gave up 182 rushing yards to the Jets last week. That includes Breece Hall gaining 107 yards on 5.6 yards per carry. Maybe the Pittsburgh defense is more buttoned-up at home, but there's still value in backing Kenneth Walker's rushing prop. 

                  Walker was quiet in Week 1 with just 20 yards on 10 carries. Zach Charbonnet was actually more productive, but Walker should see a bigger workload this time around. He's still the lead back, and he can bounce back after barely doing anything last week. Getting to 50+ rushing yards is a low bar for someone who averaged 52.1 yards per game last year and 60.3 two seasons ago. 

                  It's only a one-game sample size, but the Steelers' offense revealed some things last week in Aaron Rodgers' debut. First, Calvin Austin could be a main target in the passing game. Plus, Jaylen Warren is the first man up in the backfield with an established role. 

                  As for Austin, his six targets and 70 receiving yards were both second on the team and trailed only DK Metcalf in Week 1. Metcalf is the clear No. 1, but Austin was immediately a favorite option for Rodgers as well. He had four receptions in the opener and can catch at least three this week. 

                  Warren, meanwhile, saw a team-high 11 carries while Kaleb Johnson only saw one attempt for -2 yards. Kenneth Gainwell actually logged the most snaps, but many of those were in obvious passing downs where his veteran experience in pass protection was needed. Warren should rack up the most yards of any Steelers back. 

                  Getting to 15+ receiving yards is very doable for Warren, who had 22 last week. He averaged 20.7 per game last year, with 15+ in nine out of 15 regular-season games. The Seahawks just gave up 73 receiving yards to Christian McCaffrey last week, so there's some vulnerability in covering pass-catching running backs. 

                  Parlay Odds: +405

                  Cleveland Browns at Baltimore Ravens 

                    Baltimore is fresh off a 41-40 loss to the Bills in Week 1. The game featured over 900 total yards of offense in a high-scoring shootout. This week's divisional matchup with Cleveland could be another offensive-filled game, presenting value on the over. 

                    The Ravens' offense had no issues moving the ball last week, especially on the ground, as Lamar Jackson and Derrick Henry looked fresh. Defensively, though, Baltimore allowed nearly 500 yards to Buffalo and infamously blew a 15-point fourth-quarter lead. The Ravens’ defense has to turn around and face a pass-happy Browns offense that tends to be faster-paced with Joe Flacco at quarterback. 

                    Cleveland played in a low-scoring 17-16 loss to the Bengals last week. As noted in last week's article, the over was 8-3 in Flacco's last 11 starts before hitting the under in Week 1. There were 53.1 PPG scored on average in those games, too. Expect the game flow this time around to be quicker with more offensive success on both sides.

                    Flacco himself should play a key role in this being a higher-scoring contest. He threw for 290 yards on a whopping 45 pass attempts in Week 1. This is what he does. Flacco averaged 265.5 passing yards and 37 attempts in six starts last year with Indianapolis. In five starts with the Browns in 2023, he averaged 323.2 yards on 40.8 attempts per game. Plus, he's thrown 250+ yards in 10 of his last 12 starts.  

                    Browns rookie tight end Harold Fannin Jr. was all the rage in Week 1, as he had seven catches for 63 yards. Don't forget about David Njoku, though. The veteran should still be a favorite option for Flacco moving forward. Njoku had just three catches for 37 yards in Week 1, but his six targets were a good sign. Two years ago, Njoku had 90+ yards in four of Flacco's six starts (including the playoffs) with Cleveland. 

                    Parlay Odds: +305

                    Denver Broncos at Indianapolis Colts 

                      It doesn't get much better than the Colts' offensive success in Week 1. They scored on all seven possessions while putting up 33 points. That probably had more to do with the soft matchup against a Dolphins defense expected to be among the NFL's worst this year. The competition ramps up with Denver’s arrival this week. 

                      Negative regression is likely coming for an offense that didn't punt or turn it over in the opener. The Broncos allowed just 18.3 PPG last year (third) and held the Titans to 12 points in Week 1. It's one of the best defenses in the league and will present a tough test for the Colts, even if the latter is at home here. 

                      One Indy player who can still have a solid game, though, is rookie tight end Tyler Warren. The Colts drafted him in the first round for a reason, and his Week 1 usage was encouraging. Warren's nine targets and seven receptions both led the team as he racked up 76 receiving yards. He's going to be a top weapon in the offense and a favorite target for Daniel Jones. 

                      On the Broncos' side of things, rookie RJ Harvey flashed in Week 1 as well. The running back had 70 rushing yards, including a breakaway 50-yard run. He only saw six carries, but that number should rise as Denver realizes he's a playmaker. Even if we take out his 50-yard gain, Harvey still averaged five yards per carry on his five other attempts. 

                      Parlay Odds: +465

                      Carolina Panthers at Arizona Cardinals 

                        A year ago, the Panthers had the worst run defense in the NFL, allowing 179.8 rushing yards per game. Those issues haven't gone away based on last week's showing. Carolina gave up 200 rushing yards and 6.3 yards per carry to the Jaguars in the opener. Jacksonville running back Travis Etienne racked up 143 yards on 8.9 yards per carry, too. 

                        It's a prime matchup for James Conner. The Cardinals' lead back only had 39 yards on 12 carries last week. He should rebound with a better performance at home in this spot, though. Conner averaged 68.4 rush yards per game last season and 80 yards per game in 2023. He's still the No. 1 RB in this Arizona offense and should see more touches with a favorable game script incoming.

                        Kyler Murray can also have success as a runner in this matchup. The dual-threat ability is well-documented at this point, and he should look to use his legs early in the season at his healthiest. Murray averaged 33.6 rushing yards per game last year, with 25+ yards in nine out of 17 games. In Week 1, he had 38 yards on the ground with some designed runs and active scrambles. 

                        On the Panthers' side of things, rookie wideout Tetairoa McMillan has already established himself as a top weapon. His nine targets, five catches and 68 receiving yards all led the team by a decent margin in Week 1. McMillan is a clear favorite option for Bryce Young with Adam Thielen gone and Jalen Coker on IR. Plus, Carolina will likely have to throw more while trailing in this game. 

                        Parlay Odds: +380

                        Philadelphia Eagles at Kansas City Chiefs 

                        (Odds courtesy of BetMGM)

                          In this Super Bowl rematch, let's roll with a trio of player props in what should be an offensive-minded game. It starts with Jalen Hurts, who ran for 62 yards and two touchdowns in Week 1. He was an active runner with 14 rush attempts. All we care about for our parlay, though, is Hurts scoring a touchdown. 

                          If you didn't know, that's been a common occurrence in recent years. Hurts has now scored 42 total rushing touchdowns over his last 48 regular-season games. He also scored in 13 out of 19 total games last year, including the playoffs. Whether it's the tush push on the goal line or while scrambling, like how he scored both times last week, Hurts just has a knack for getting into the end zone. 

                          DeVonta Smith had a quiet season opener with only three catches for 16 yards. Expect more targets and a larger role in the Eagles' offense this week. Smith has tormented the Chiefs in the past. He has 122, 100, 99 and 69 yards in four career games against this defense. Meanwhile, Kansas City's secondary looked very vulnerable last week and had trouble covering the Chargers' wideouts. Look for Smith to find open space and be more involved. 

                          On the Chiefs' side, Marquise Brown just went off for 99 yards on 10 receptions in Week 1. He also saw a whopping 16 targets from Patrick Mahomes. With Xavier Worthy and Rashee Rice both out, Brown should continue to be locked into targets. It's basically him and Travis Kelce as the trusted pass-catchers for Mahomes right now. 

                          Meanwhile, the Eagles' second cornerback spot is shaky opposite of Quinyon Mitchell. The Cowboys targeted that matchup all night in Week 1 as CeeDee Lamb exploded for 110 yards, with some drops as well. The Chiefs should look to get Brown matched up against the Eagles' second corner, allowing him to clear 61.5 yards. 

                          Parlay Odds: +500 

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