NFL Week 3 Odds, Picks & Predictions: 49ers vs. Broncos (2022)

Here are our odds, picks, and predictions for this NFL Week 3 matchup: 49ers vs. Broncos.

Claim 1 FREE year of BettingPros Premium access >>

NFL Week 3 Odds, Picks & Predictions: 49ers vs. Broncos

Russell Wilson will be playing a familiar foe on Sunday night. The best defense in terms of yardage will be coming to Denver to take on a struggling Broncos offense. They have moved the ball well but have failed to score points. On six red zone trips, they have scored zero TDs. Another problem is the number of penalties they have received this season. They have been flagged 25 times for 206 yards. Penalties are a problem against the 49ers, who allow 226.5 yards per game. They are not a team that the Broncos can afford to lose yards to mental errors.

On offense for the 49ers, Jimmy Garoppolo replaces the injured Trey Lance. He led them to the NFC Championship last season, so they are fortunate to have signed him before the season. He will have a tough test in his first start.

Pick: Broncos +1.5, u44.5

What is Betting Against the Spread?

Betting “against the spread” refers to the act of choosing the winning team based on a numeric handicap placed on the team that oddsmakers believe is superior, rather than picking the outright winner. For example, if the Rams face the Bengals, and oddsmakers set the spread at Rams -3.5, you would need Los Angeles to win by 4 or more points in order to cash your Rams bet.

What is an Over/Under Bet?

Over/Under is a wager based on how many points you think will be scored in a specific game. Oddsmakers set the total, and bettors decide whether the final score will be higher or lower than that number. If an Over/Under is set at 44.5 points and you bet Over, you will need the combined score of both teams to be 45 points or higher to win your bet.

What is a Moneyline Bet?

A moneyline bet involves choosing which team you believe will win a specific matchup. The moneyline favorite carries a minus designation, like -130. This means that you need to wager $130 to earn a $100 profit. Conversely, the underdog carries a plus designation, like +110. This means that you win $110 in profit on a $100 bet.

Prop Bet Analyzer: View top rated props and historical prop performance by player >>


Subscribe: Apple Podcasts | Spotify | Google Podcasts | Stitcher | RadioPublic | Breaker | Castbox | Pocket Casts

Whether you’re new to sports betting or a betting pro, our How To Bet and Sports Betting Strategy and Advice pages are for you. You can get started with our How To Section — including How to Avoid the 7 Biggest Sports Betting Mistakes â€” or head to a more advanced strategy — like Thinking Like an Expert Sports Bettor â€” to learn more.