NFL Week 3 Odds, Picks & Predictions: Rams vs. Cardinals (2022)

Here are our odds, picks, and predictions for this NFL Week 3 matchup: Rams vs. Cardinals.

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NFL Week 3 Odds, Picks & Predictions: Rams vs. Cardinals

The Cardinals welcome their divisional rival coming off an exhilarating win over the Raiders in week 2. Kyler Murray became the savior for the Cardinals with his video-game-like 2-point plays late in the 4th quarter. They will look to keep the momentum going versus a talented and deep Rams roster.

Since 2018, there has not been one regular season game between these two teams that has been closer than 7 points. The average winning margin in the eight games played from 2018 – 2021 was 16.25 points, and I don’t see this trend coming to a halt here in week 3.

The Rams are the better team. Look for a shootout and the Rams to pull away in the 4th quarter.

Pick: Rams -3.5, o48.5

What is Betting Against the Spread?

Betting “against the spread” refers to the act of choosing the winning team based on a numeric handicap placed on the team that oddsmakers believe is superior, rather than picking the outright winner. For example, if the Rams face the Bengals, and oddsmakers set the spread at Rams -3.5, you would need Los Angeles to win by 4 or more points in order to cash your Rams bet.

What is an Over/Under Bet?

Over/Under is a wager based on how many points you think will be scored in a specific game. Oddsmakers set the total, and bettors decide whether the final score will be higher or lower than that number. If an Over/Under is set at 44.5 points and you bet Over, you will need the combined score of both teams to be 45 points or higher to win your bet.

What is a Moneyline Bet?

A moneyline bet involves choosing which team you believe will win a specific matchup. The moneyline favorite carries a minus designation, like -130. This means that you need to wager $130 to earn a $100 profit. Conversely, the underdog carries a plus designation, like +110. This means that you win $110 in profit on a $100 bet.

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