NFL Week 4 Odds, Picks & Predictions: Cardinals vs. Panthers (2022)

Here is an early look at our odds, picks, and predictions for the NFL Week 4 game, Cardinals vs. Panthers.

And check out a few of our other favorite bets for Week 4:

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NFL Week 4 Odds, Picks & Predictions: Cardinals vs. Panthers

The Arizona Cardinals are the only team in the league that has not scored in the first quarter. They have most of their points in the fourth quarter. The Panthers have allowed only six points scored in the first quarter this season and 26 points in the fourth quarter. The Cardinals will likely start slowly in this game only to storm back in the second half. They will likely succeed on the ground as the Panthers allow 4.3 yards per rush attempt. Although James Conner is questionable with a knee injury, so they may be without their best back. As a team, the Cardinals have averaged 4.5 yards per rush attempt. Another concern for the Cardinals is Matt Prater practicing in a limited capacity due to a hip injury. It will likely be a competitive game, and points will be of the utmost importance.

Panthers -1.5, Lean o42.5

What is Betting Against the Spread?

Betting “against the spread” refers to the act of choosing the winning team based on a numeric handicap placed on the team that oddsmakers believe is superior, rather than picking the outright winner. For example, if the Rams face the Bengals, and oddsmakers set the spread at Rams -3.5, you would need Los Angeles to win by 4 or more points in order to cash your Rams bet.

What is an Over/Under Bet?

Over/Under is a wager based on how many points you think will be scored in a specific game. Oddsmakers set the total, and bettors decide whether the final score will be higher or lower than that number. If an Over/Under is set at 44.5 points and you bet Over, you will need the combined score of both teams to be 45 points or higher to win your bet.

What is a Moneyline Bet?

A moneyline bet involves choosing which team you believe will win a specific matchup. The moneyline favorite carries a minus designation, like -130. This means that you need to wager $130 to earn a $100 profit. Conversely, the underdog carries a plus designation, like +110. This means that you win $110 in profit on a $100 bet.

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