NFL Week 4 Odds, Picks & Predictions: Titans vs. Colts (2022)

Here is an early look at our odds, picks, and predictions for the NFL Week 4 game, Titans vs. Colts.

And check out a few of our other favorite bets for Week 4:

Prop Bet Analyzer: View top rated props and historical prop performance by player >>

NFL Week 4 Odds, Picks & Predictions: Titans vs. Colts

The Colts’ win over Kansas City was a necessary fluke. Indianapolis was outplayed in nearly every facet of the game, and were KC to have a healthy place-kicker the Colts would be the definition of disappointment in the NFL through three weeks.

Regardless, a win is a win. And an opportunity for Indy string together consecutive wins versus a division foe could be momentous for their season’s outlook.

Tennessee has struggled as well, and one should not interpret their victory over Las Vegas as a sign that they have overcome their own deficiencies. The Titans currently have the sixth-worst defensive EPA / Play in the NFL, and the Colts are surely aware of their opportunity to exploit such a porous unit.

Lean Colts -3.5, u42.5

What is Betting Against the Spread?

Betting “against the spread” refers to the act of choosing the winning team based on a numeric handicap placed on the team that oddsmakers believe is superior, rather than picking the outright winner. For example, if the Rams face the Bengals, and oddsmakers set the spread at Rams -3.5, you would need Los Angeles to win by 4 or more points in order to cash your Rams bet.

What is an Over/Under Bet?

Over/Under is a wager based on how many points you think will be scored in a specific game. Oddsmakers set the total, and bettors decide whether the final score will be higher or lower than that number. If an Over/Under is set at 44.5 points and you bet Over, you will need the combined score of both teams to be 45 points or higher to win your bet.

What is a Moneyline Bet?

A moneyline bet involves choosing which team you believe will win a specific matchup. The moneyline favorite carries a minus designation, like -130. This means that you need to wager $130 to earn a $100 profit. Conversely, the underdog carries a plus designation, like +110. This means that you win $110 in profit on a $100 bet.

Subscribe: Apple Podcasts | Spotify | Google Podcasts | Stitcher | RadioPublic | Breaker | Castbox | Pocket Casts

Whether you’re new to sports betting or a betting pro, our How To Bet and Sports Betting Strategy and Advice pages are for you. You can get started with our How To Section — including How to Avoid the 7 Biggest Sports Betting Mistakes â€” or head to a more advanced strategy — like Thinking Like an Expert Sports Bettor â€” to learn more.