NFL Week 6 Picks, Predictions and Parlays
Greetings, friends. Welcome to Week 6 of my weekly NFL sports betting column. We had another solid week in Week 5, though a banger Thursday did a lot of the heavy lifting, while our Sunday and Monday were meh overall. We were a play or two away from having an insane week, but alas, such is life when you are heavy on parlays, as I usually am.
But still, we ended up +9.66 units, and I’ll take that any week. That puts us up over 40 units on the season, with only one losing week so far. There will undoubtedly be more losing weeks in the future, but we’re off to a great start.
Over the last two weeks, big Thursday nights carried a lot of weight. This week, I wasn’t able to fire off my picks ahead of Thursday Night Football, which actually worked about because I didn’t do great overall. My wife having COVID and throwing a wrench into things on the home front for me may have worked in our favor.
Here’s where we stand after five weeks:
- Week 1: 48-38, +5u
- Week 2: 35-42, -4u
- Week 3: 24-18, +10.6u
- Week 4: 28-16, +19.67u
- Week 5: 45-37, +9.66u
Overall: 180-151, +40.93u
As I mentioned previously, the total units are a little tricky to calculate because they usually include some cross-sport parlays and because some plays are used multiple times. So I try to take the most honest approach and grade each play individually at the odds I got. If it’s an all-NFL parlay, I’ll list it in the parlays section and grade it accordingly. Otherwise, we’ll track individual plays.
Here is my Week 1 article if you want to go back and take a look at how we started. I explain a bit more about my process there.
Now, let’s get to some Week 6 bets.
- Best +EV NFL Picks
- NFL Prop Bet Cheat Sheet
- Tail Sharp NFL Bettors at Better Prices
- Optimize Your PrizePicks Prop Plays
NFL Week 6 Best Bets
Since I post a high volume of picks, I’ll share a table version of the picks first. I’ll add to this throughout the week as I add more picks. Where relevant, I’ll add some notes below the table to provide additional context. But know that, for the most part, I am betting prices with a focus on +EV (expected value) compared to sharp sportsbooks and following sharp liquidity on prediction markets.
| Player / Team / Game | Side | Line | Market | Odds | Book |
| Bo Melton | Under | 16.5 | Receiving Yards | 100 | PrizePicks |
| Reed Blankenship | Over | 6.5 | Tackles + Assists | -122 | Betr |
| Nico Collins | Over | 62.5 | Receiving Yards | -122 | Betr |
| Tyler Bass | Over | 1.5 | Field Goals Made | -122 | Betr |
| Nico Collins | Over | 5.5 | Receptions | -119 | PrizePicks |
| Jonathan Taylor | Under | 20 | Fantasy Score | -119 | PrizePicks |
| Kenneth Walker III | Under | 20 | Fantasy Score | -119 | PrizePicks |
| Deshaun Watson | Over | 15.45 | Fantasy Points | -115 | Underdog |
| Dalton Kincaid | Under | 4.5 | Receptions | -122 | Betr |
| Bhayshul Tuten | Over | 1.5 | Receptions | -137 | Onyx Odds |
| Keenan Allen | Over | 3.5 | Receptions | -122 | PrizePicks |
| Devaughn Vele | OUnder | 4.5 | Receptions | -122 | PrizePicks |
| Trey McBride | Under | 7.5 | Receptions | 200 | Betr |
| Kirk Cousins | Under | 1.5 | Rushing Yards | parlay | Betr |
| Brian Thomas Jr. | Over | 15.5 | Receiving Yards | -113 | Onyx Odds |
| C.J. Stroud | Under | 258.5 | Passing Yards | -113 | Onyx Odds |
| Tyler Shough | Under | 36.5 | Pass Attempts | -115 | Underdog |
| Josh Allen | Under | 0.5 | Touchdowns | 144 | Kalshi |
| Dontayvion Wicks | Over | 24.5 | Receiving Yards | -138 | Kalshi |
| Dontayvion Wicks | Over | 39.5 | Receiving Yards | 41% | Polymarket |
| Dontayvion Wicks | Over | 49.5 | Receiving Yards | 29% | Polymarket |
| Dontayvion Wicks | Over | 3.5 | Receptions | 31% | Polymarket |
| Dallas Goedert | Over | 29.5 | Receiving Yards | 62% | Polymarket |
| Makai Lemon | Over | 39.5 | Receiving Yards | 18% | Polymarket |
| Makai Lemon | Over | 2.5 | Receptions | 36% | Polymarket |
| Dallas Goedert | Over | 39.5 | Receiving Yards | 45% | Polymarket |
| Makai Lemon | Over | 29.5 | Receiving Yards | 29% | Polymarket |
| Dallas Goedert | Over | 19.5 | Receiving Yards | 76% | Polymarket |
| Makai Lemon | Over | 9.5 | Receiving Yards | 66% | Polymarket |
| Makai Lemon | Over | 19.5 | Receiving Yards | 45% | Polymarket |
| Dontayvion Wicks | Over | 2.5 | Receptions | 49% | Polymarket |
| Carnell Tate | Under | 4.5 | Receptions | -111 | Betr |
| Patrick Mahomes | Over | 1.5 | Pass TDs | 100 | BetMGM |
| Cam Skattebo | Under | 11.5 | Rush Attempts | 350 | Underdog |
| Omar Cooper | Under | 1.5 | Receptions | parlay | Underdog |
| Najee Harris | Over | 32.5 | Rushing Yards | -113 | DraftKings |
| Cyrus Allen | Under | 16.5 | Receiving Yards | -113 | Onyx Odds |
| Tanner McKee | Over | 18.5 | Pass Completions | 100 | PrizePicks |
| KC Concepcion Jr. | Under | 4.5 | Receptions | 100 | PrizePicks |
* Note: More info on this below in the PrizePicks and Underdog section, but the odds for the pickem platforms are dependent on playing the appropriate lineup sizes that offer you those odds. If you play other lineup sizes, you’ll get worse odds.
NFL Week 6 Game-by-Game Picks
Coming Soon
NFL Week 6 Parlays
With the caveat that many of my parlay slips are multi-sport and I really only focus on value (+EV picks = +EV parlays) and being careful about correlation penalties, here are some of NFL-only slips I have for Week 5:
Underdog 2-pick Standard (+350)
- Cam Skattebo Under 11.5 Rush Attempts 350 (Underdog)
- Omar Cooper Under 1.5 Receptions parlay (Underdog)
Underdog 2-pick Standard (+350)
- Oronde Gadsden Over 1.5 Receptions 350 (Underdog)
- Kirk Cousins Over 31.5 Longest Completion parlay (Underdog)
Sleeper Picks (+293, Drake London boost)
- Drake London Over 6.5 Receptions 293 (Sleeper Picks)
- Christian McCaffrey Over 61.5 Rushing Yards parlay (Sleeper Picks)
*** I’ll add parlays here throughout the week and weekend as I log them, but see Underdog, PrizePicks, and Betr plays above for a list of picks that make up various parlays (often cross-sport ones).
How I Find My NFL Best Bets
I'm a positive expected value bettor, and I bet volume. I'm looking for prices that I believe give me an edge, then making enough of those bets for that edge to have a chance to play out over time. There will be losses. Sometimes several in a row. I'm comfortable with that as long as the process and the prices make sense.
Each week, I'll share my NFL best bets here and keep adding picks through Thursday Night Football, into the weekend, and sometimes right up to Sunday kickoff. Expect straight bets and player props, plus parlays, PrizePicks and Underdog entries, and sportsbook discounts or boosts I think are worth playing.
I'll use the BettingPros Market-Based EV tool, Smart Money tool, PrizePicks and Underdog optimizers, Prop Bet Cheat Sheet, Whale Tracker, odds pages, and likely some other BP tools along the way to help build the card. Each pick will include which tool helped me find it, so you can follow the process yourself.
The price matters. I can’t emphasize that enough. I’m betting the PRICE more than anything else. When you see a play from me and the current price is significantly worse, you should probably avoid it. In some cases, I’ll include how far I’m willing to go with a number. So, always check the current number before following a pick. A bet I liked on Monday might offer very different value by Sunday morning. I’ll list the line and the odds I played alongside each selection and keep adding to the card as I find more bets.
NFL PrizePicks, Underdog & DFS/Pickem Picks
When I build a PrizePicks or Underdog entry, I start with the individual picks and the price I'm effectively paying for each one. A big payout doesn't do much for me if I have to add a couple of bad picks to get there.
The slip format matters. With standard payouts, the best options on PrizePicks and Underdog are:
- Underdog: 2-pick Standard, which works out to approximately -115 per pick.
- PrizePicks: 5-pick Flex or 6-pick Flex, at approximately -119 and -118 per pick, respectively.
Those are effective odds calculated from the full payout structure, including partial payouts when some picks miss. They give me a baseline for comparing each selection with the sportsbook market.
Here’s a video Andrew Erickson recorded where he walks through the PrizePicks Optimizer and the strategy behind using it. The same applies for Underdog, just with different odds and slip sizes (see above). Watch the video here. And if you have any questions, shoot me a DM on Twitter/X (@mikeMaher).
I'll use the BettingPros PrizePicks and Underdog optimizers to find those edges and share my selections below. Focus on the individual lines when following along, and check your entry's payout before submitting. Discounts and adjusted multipliers can change the math. I'm happy to wait for another good pick instead of forcing one to fill a slip.
Again, we’re focusing on individual picks here. We want each individual pick to be a good one, so we’re less worried about every slip hitting and more focused on each individual pick providing value. Below, I’ll share each pick individually (I may have the same pick in multiple slips) and will share some of the completed slips I built throughout the week.
What is the Smart Money Tool?
Watch this walkthrough of the Smart Money board and how the tool works. If you'd rather watch than read, start with this Smart Money tutorial.
Smart Money is a new tool at BettingPros that focuses on sharp money on prediction markets called liquidity. While prediction markets are technically peer-to-peer, we know they’re filled with sharp bettors, whales, trading firms, market makers, and even other sportsbooks.
The liquidity is the primary signal here. That money (available liquidity) shows us what the sharps are trying to bet on prediction markets. Smart Money shows you where you can bet the same thing, at a better price, on a sportsbook.
Kalshi, Polymarket, Novig, and ProphetX are exchanges, so the money sitting on each side of a market is public.
The tool tracks liquidity across the major prediction markets in real time and lines those prices up against every sportsbook on the board. When a market is heavily backed on one side at a number the books haven’t matched, that gap is your edge. Smart Money flags the bet, finds the best available price across all major books and exchanges, and explains the edge in plain English. It’s line shopping with the sharpest money on the screen telling you which line to shop for.