Premier League Matchday 25 Odds, Picks & Predictions (2026)
We're onto Matchday 25 of the English Premier League season, and it's still Arsenal (16-5-3) who sits atop the table with a six-point cushion over second-place Manchester City (14-5-5). The Gunners are now out to -500 favorites to secure the Premier League title.
All 20 teams are set to take the pitch this weekend, and I've got you covered from a sports betting angle. Below, I've narrowed in on three of the matches, and I'll break down each contest and provide my top Premier League bets.
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Premier League Matchday 25 Preview & Best Bets (2026)
(Odds courtesy of DraftKings Sportsbook)
Burnley (+225) vs. West Ham United (+120), DRAW (+245) | O/U 2.5 (-115/-110)
It hasn't been a fruitful season for Burnley (3-6-15, 15 points), who is on track to be relegated when the season wraps up. With that being said, they'll have a decent chance to pick up points this weekend when they welcome in 18th-place West Ham United (5-5-14, 20 points). This bottom-of-the-table clash is set for Saturday at 10:00 a.m. ET from Turf Moor in Burnley.
I won't try to convince anyone that Burnley is a good team. However, if the Clarets were ever going to put on a respectable showing for their fans, it would be this matchup against another team that resides below the relegation line. I'll lay the -150 vig and take Burnley to escape with either a win or draw.
Burnley has actually been in decent form, at least relative to their overall underwhelming season. They've managed three draws in their last five league matches, while also decimating Millwall 5-1 in the FA Cup last month. Meanwhile, West Ham has only five wins throughout 24 Premier League games this term. They've also posted an ugly 2-4-6 record on the road. The Irons' 4.2% clean sheet percentage is the worst in the league, so the Clarets should find the back of the net at least once. I think they hang on for a 1-1 draw, or maybe even notch an outright win.
Bet: Burnley +0.5 (-150)
Wolves (+370) vs. Chelsea (-150), DRAW (+320) | O/U 2.5 (-145/+115)
Chelsea (11-7-6, 40 points) has won its last three Premier League matches, catapulting themselves up the standings and into a coveted top-five position. They'll look to keep things rolling on the road this weekend against last-place Wolves (1-5-18, 8 points). Kick-off is slated for 10:00 a.m. ET from Molineux Stadium in Wolverhampton.
I'll lay the goal and back Chelsea on Saturday morning. If this squad is serious about qualifying for European soccer next season, then they must secure these three points. Luckily, the Blues have been playing well, winning three straight games in the Premier League.
Wolves have played poorly in all thirds this season, as the club enters the matchday with the worst goal differential in the league at -30 (15:45). They've managed only 15 goals offensively across 24 matches. There's a good chance that the Wanderers are held scoreless on Saturday, as they're taking on a Blues side that's third in clean sheet percentage (37.5%) and fifth in goals allowed (27) this year. Chelsea is the third-best road team in terms of points (19, 5-4-3) and second-best in terms of goal differential (+8, 22:14). They should at least win, but a multi-goal rout could be in order in this one.
Bet: Chelsea -1.0 (+110)
Liverpool (+140) vs. Manchester City (+180), DRAW (+270) | O/U 2.5 (-175/+140)
The marquee match this week comes on Sunday morning, as sixth-place Liverpool (11-6-7, 39 points) takes on second-place Manchester City (14-5-5, 47 points). The matchday finale gets underway at 11:30 a.m. ET from Anfield in Liverpool.
I'll bump this total up to 3.0 and take the Over. Liverpool is rolling offensively, having scored 15 goals across their last four matches in all competitions. They've notched multi-goal offensive performances in each of their last four contests. Being that the Reds are home, I think they'll hit the two-goal mark. City has conceded 15 goals across 12 road matches, so they haven't been completely impenetrable.
On the other hand, Liverpool's defense has been far from lights out this season. They're just 12th in goals conceded (33). They'll welcome in a Manchester City squad that's first in scoring (49 goals) this year. Pep Guardiola's men have scored 2+ goals in four straight games across all competitions. A 2-1 final score feels like the floor in this matchup of potent offenses, but I think we could see it spill over to 2-2 or 3-2. Let's take the Over.
Bet: Alternate Over 3.0 Goals (-115)