Premier League Matchday 33 Odds, Picks & Prediction (2025)
The Premier League returns after a thrilling midweek slate on the continental stage. Liverpool can secure the title this weekend, although they'll need to beat Leicester while also having Arsenal lose to lowly Ipswich Town. Regardless of whether or not the championship is settled this weekend, it's only a matter of time until the Reds lock it up.
Below, I'll dive into my three favorite Premier League bets for Matchday 33.
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Premier League Matchday 33 Preview & Best Bets (2025)
(Odds courtesy of DraftKings Sportsbook)
Aston Villa (+140) vs. Newcastle United (+175), DRAW (+265) | O/U 2.5 (-165/+130)
Saturday's five-match schedule wraps up in Birmingham with a high-stakes clash between Aston Villa and Newcastle. The hosts are currently in seventh place in the table at 15-9-8 (54 points), while the visiting Magpies occupy third place at 18-5-9 (59 points). Kickoff is set for 12:30 p.m. ET from Villa Park in Birmingham.
Aston Villa was just ushered out of the Champions League by Paris Saint-Germain, with the main reason being their lack of defensive structure. They lost 5-4 in the aggregate, and both matches cleared the 3.0-goal threshold. The Villans have now seen at least 3.0 goals in their last seven matches in all competitions. I think that trend will continue at home on Saturday in this battle of dangerous offenses. I'm taking the Alternate Over 3.0 goals.
As for Newcastle, they've won their last six matches outright, and five of those contests have seen 3.0+ goals. Offensively, the Magpies are averaging 2.8 goals per match during the six-game sample size. Overall, Newcastle is third in the PL in scoring (61 goals), while Aston Villa is 11th (49). Let's lock in the over 3.0 goals in this one.
Bet: Alternate Over 3.0 Goals (-110)
Leicester (+1100) vs. Liverpool (-475), DRAW (+600) | O/U 3.5 (+105/-135)
As I mentioned above, the first-place Reds (23-7-2, 76 points) have the title within their grasp. They'll look to secure three points on the road against a Leicester team that's on the fast track to relegation, residing in 19th place at 4-6-22 (18 points). This contest is set for Sunday morning at 11:30 a.m. ET from King Power Stadium in Leicester.
The Foxes are coming off a 2-2 road draw against Brighton, and these were the first goals that the team had scored since February 7! They were previously on a seven-match slide in the Premier League, where they were out-scored 17-0. Unfortunately for the Leicester faithful, I think it'll be back to their scoreless ways in this contest against Liverpool. I'll back the Reds to win this road match to nil.
Arne Slot's defense has been masterful this season, ranking second behind only Arsenal in goals against (27 vs. 31). They're also second in xGA (28.2), and across 32 matches, both of those metrics average out to allowing less than a goal per game. The Reds should have no issue stifling the Foxes offensively in this contest. Leicester is averaging only 0.8 goals per match this campaign, which is the second-worst in the PL. I'm taking the Reds to win to nil, as they continue their quest for the title.
Pick: Liverpool to Win to Zero (-125)
Tottenham (+145) vs. Nottingham Forest (+170), DRAW (+265) | O/U 2.5 (-165/+130)
The matchday wraps up with a fun tie on Monday, as Tottenham hosts Nottingham Forest. The Trees are trying to hold onto a coveted top-four spot, and they're currently in fourth place at 17-6-9 (57 points). They'll take on Tottenham, who has put together a forgettable campaign, going just 11-4-17 (15th, 37 points) this year. The matchday finale gets underway at 3:00 p.m. ET from Tottenham Hotspur Stadium in London.
Like the Aston Villa vs. Newcastle match, I'm expecting some scoring in this clash in the capital city. I'm taking the Alternate Over 3.0 Goals in London on Monday. Forest's defense has been a bit shaky at times recently. Specifically, the defense has been a liability on the road, as the Trees have allowed 27 goals in 16 road contests (1.7 GA/M). Tottenham is the fourth-best offense in the Premier League (60 goals), and they should be able to score once or twice in this contest.
As for the Spurs' defense, it has been a major issue this season. They've allowed 49 goals across 32 matches, which is the seventh-worst mark in the league. In terms of xGA, they're the fourth-worst (52.8). Nottingham Forest is averaging 1.6 goals per match offensively this season, and they should pick apart this lowly Tottenham defense as they attempt to maintain a top-four spot in the table. The floor for this match feels like a 2-1 outcome, but the ceiling is much higher, in my opinion. I'm taking the Over.
Pick: Alternate Over 3.0 Goals (-110)