San Francisco 49ers vs. Los Angeles Rams Prop Bets (2022)

For the second time in the playoffs this year, the Rams will face off against an NFC West rival. San Fransisco has gotten the better of Los Angeles in both matchups including 31-10 blowout earlier this season. Are the 49ers destined to make their second Super Bowl appearance in three yards, or will the Rams make their second appearance with Sean McVay? We’ll look at some of the key players’ props and see how they’ll make an impact in this game.

View the best player prop bets for this week’s slate with our NFL Prop Bet Cheat Sheet >>

Elijah Mitchell Rushing Yards O/U 69.5

Elijah Mitchell has become the guy the 49ers rely on in the backfield, and he has come through. In the 13 games he’s played this season, Mitchell has rushed for 72 or more yards eight times, along with 85 or more yards in both games against the Rams. The Rams are tough against the run allowing the fewest rushing yards per game in the regular season and the playoffs, but they’ve been torched by San Fransisco with 291 total rushing yards in two games this season. They’re going to keep the ball out of Jimmy Garoppolo’s hands and run it down the Rams’ throat, staying with the success that has gotten them to this point.

Pick: Over 69.5

Jimmy Garoppolo Interceptions O/U 0.5

During the playoffs, Jimmy G has received some criticism and is looked at as a member of the group project that does nothing and still got the same grade. He hasn’t needed to do much as the defense and run game have led this team to one game away from their second Super Bowl in three years. Garoppolo has not been a stranger to the turnovers as he’s thrown it to the opposition six times in the last four games, and this includes twice in the previous game at SoFi against the Rams. It will come to a point in this game where he’ll make that critical mistake.

Pick: Over 0.5

Tyler Higbee Receiving Yards O/U 40.5

Higbee has had a rebound year thanks to Matthew Stafford at quarterback. Since Week 13, he’s second on the team in targets (29) and a catch percentage (71) to obviously Cooper Kupp. Most important to note is the trust Stafford has for Higbee in the red zone — he finished with the team’s best red zone completion percentage (70.5). In the final game of the regular season against San Francisco, he had two touchdowns against San Fransisco, and we should expect it again. 

Pick: Over 40.5 & Anytime TD

Matthew Stafford Pass Completions O/U 23.5

This is an absurdly low number for a guy who was seventh in pass attempts this season (404), didn’t have less than 25 pass attempts all season, and no less than 30 attempts since Week 6. When you have pass-catchers like Van Jefferson, Odell Beckham Jr., and Cooper Kupp, you’re going to get the ball to those guys.

Pick: Over 23.5

Cam Akers Rushing Yards O/U 63.5

Akers has been getting the ball quite a bit since returning from a torn Achilles, but it’s taking him some time to be effective. He’s averaging an astonishing 20.5 carries per game in the playoffs but only 2.2 yards per attempt. San Francisco is sixth in rushing yards per carry this season (4.0), and the Rams are only averaging 3.0 yards per carry in the two games against the 49ers this season. Although Sony Michel did not get as much playing last week as he did in the Wild Card game, he’s still a factor, and there’s a possibility of Darrell Henderson returning from a knee injury that could cut into Akers’ carries.

Pick: Under 63.5

Whether you’re new to sports betting or a betting pro, our How To Bet and Sports Betting Strategy and Advice pages are for you. You can get started with our 101 section — including How to Bet on Sports â€” or head to more advanced strategy — like 10 Tips to Become a Sharper Sports Bettor â€” to learn more.