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Best NFL Player Props & Picks: 49ers vs. Cowboys (Week 10)

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The San Francisco 49ers visit the Dallas Cowboys on Sunday for a Week 10 matchup, with SF -4.5 and a total of 55.5 on the supplied odds board. Looking for 49ers vs. Cowboys player props? The BettingPros NFL Prop Bet Cheat Sheet has generated +210 units and a 4.8% ROI across 4,395 picks rated 3-5 stars, with a 53.8% win rate and a five-week winning streak. Rushing-yard props lead the way at +79.7 units, followed by receptions at +52.6 units. Below are our matchup analysis, picks, same game parlay and player prop tools.

NFL Player Props, Picks & Predictions: 49ers vs. Cowboys

49ers vs. Cowboys Game Information & Odds

  • When: Sunday, November 15, 2026, 4:25 p.m. ET
  • TV: FOX
  • Location: AT&T Stadium, Arlington, TX
  • Spread: SF -4.5
  • Total: 55.5

Matchup odds supplied via DraftKings. Analyst picks and parlay prices below reflect the source articles and may differ from the matchup odds above.

Here are Andrew Erickson's predictions for 49ers vs. Cowboys. Read all of his NFL Week 10 picks and predictions.

49ers vs. Cowboys Preview & Picks

Erickson's pick: Over 55.5

Closing totals of 52 or higher are 7-4 toward the Over in 2026 (11 games, through Week 9). The only other 2026 game with a closing total of 55.5 was Green Bay at Detroit in Week 7, which finished with 37 points and went Under. That GB-DET game is the only game since 2022 to close at 55.5 or higher…and not hit the over. The other four games…all went over, averaging 67.6 PPG across all five games. So although the number feels scary big…history suggests we get fireworks in Jerry World.

Dallas allowed 33 points to Arizona and 23 to the Colts over the last two weeks, so how many are they going to allow to the 49ers? Kyle Shanahan and Brock Purdy can do whatever they want against this Dallas defense, and Dak Prescott and the offense are going to have to score every single time they get the ball, because the defense is going to allow points every time it goes on the field. It feels like the Niners are a lock to get over 30 points in this game. The question on the total is whether this is one of those Cowboys games like the back-to-back against Tampa Bay and Green Bay where they scored 16 and 13. They’ve had some dud games, but for the most part they’ve been getting over 25, and if you feel like the Niners are definitely getting 30, then we are hitting the over.  Especially if Joey Porter Jr. doesn’t play again (although the team seems optimistic about his availability)

Per Next Gen Stats: The Cowboys’ defense has allowed a 37.6% success rate across 93 dropbacks with Joey Porter Jr. on the field this season, a mark that would rank lower than the Vikings’ league-leading rate of 38.5% over the full season. When deploying man coverage with Porter Jr. on the field, Dallas has allowed 3.6 yards per play, which would rank fourth-fewest in the NFL.

Across 248 dropbacks with Porter Jr. off the field, they have allowed a 50.4% success rate, which would rank third-highest in the NFL.

The 49ers have two banged-up CBs as well: Renardo Green and Deommodore Lenoir (combined for the most snaps played for the Niners among CBs this season).

Dak Prescott leads the league with 1,947 passing yards while not under pressure, in addition to posting 15 touchdowns (to four interceptions), a 110.2 passer rating, 8.1 yards per attempt, a 55.0% success rate, and 0.32 EPA per dropback. The 49ers’ defense has generated a 31.6% pressure rate this season, the third-lowest mark in the league. San Francisco has also surrendered over 20 fantasy points to two of the last three QBs they have faced (21.0 to Jayden Daniels and 20.42 to Michael Penix Jr.) - Prescott has gone over 18 points in six of his last eight games, including three in a row (NGS).

With a full arsenal of WRs to throw to this weekend, Prescott should deal with a defense that ranks 30th in pressure rate this season. Can’t say I’m as optimistic about the run game for Big D.

Javonte Williams has gone over 61.5 rushing yards only 4 times this season, twice in the last 3 weeks, but it took 20 and 25 carries against the Colts and Eagles to do it.
The 49ers are a tough run defense (No.1 run in EPA/rush faced this season), and no running back has passed 63 rushing yards against them since Week 3. Dallas offensive coordinator Klayton Adams said Thursday (11/12) that he is wary of Williams’ heavy workload. He called Williams a physical runner who seeks contact and has done a great job for the offense, and said the team has to figure out who the next man up is and how to use him properly, because it is easy to wear a back out this time of year (S/O Coachspeak Index). Dallas added Kendre Miller to the backfield after he was released from the Saints. Izzy Abanikanda will be RB2 this week, while FB Hunter Luepke is also expected to see more touches.

Props & Picks

Best NFL Same Game Parlay for 49ers vs. Cowboys

Here is our top NFL same game parlay for 49ers vs. Cowboys. View all of our Week 10 NFL same game parlays. Parlay odds courtesy of DraftKings Sportsbook.

Dallas has struggled to contain scrambling quarterbacks this season. The Cowboys allow five rushing attempts and 26.9 rushing yards per game to quarterbacks. That's the second- and third-most in the league, respectively. It's an ideal matchup for Brock Purdy to use his legs.

Purdy has already run for 201 yards this season, averaging 25.1 yards per game. He also has 20+ yards in six of eight games. Purdy is one of the better scrambling quarterbacks, and Dallas could have issues when the pocket or coverage breaks down. He should easily hit 20+ rushing yards this week.

Meanwhile, Kaelon Black is the player to target in San Francisco's backfield. The 49ers continue to give him more work while managing Christian McCaffrey's touches. Black had 11 carries for 70 yards last week, and 12 carries for 63 yards the week before. He now faces a Dallas defense that's allowed the second-most rushing yards per game this year and five yards per carry. Even if McCaffrey is productive, Black can also get to 30+ yards. He's done it in three straight games.

On the Cowboys' side, Javonte Williams has value as a pass-catcher. The 49ers allow a league-high 6.8 receptions per game to opposing running backs for 43.6 receiving yards, the fourth-most. The matchup alone makes Williams a safe bet in the passing game. He has 15+ receiving yards in five games this year. He's also seen a huge workload lately, with at least 24 touches in three straight games.

Parlay Odds: +455

Best NFL Player Props for 49ers vs. Cowboys

We compiled several projection sources to come up with consensus projections. We then compared these projections to the NFL player prop bet odds from the sportsbooks to give you the best NFL player prop bet picks. View the best player prop bets for this week’s slate with our NFL Prop Bet Cheat Sheet.

Our NFL Player Prop Bet Cheat Sheet assists bettors by comparing lines from leading sportsbooks with our daily NFL projections.

What is an NFL player prop bet?

An NFL player prop bet is a type of wager where you’re betting on the performance of a specific player in a game rather than the overall outcome. For example, you might place a bet on how many passing yards a quarterback will throw for, or how many touchdowns a running back will score. It’s a fun way to get more invested in the action, especially if you’re confident in how a particular player will perform, regardless of who wins or loses the game. It’s like focusing on one slice of the pie instead of the whole thing.

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