MLB Moneyline, Over/Under, Run Line Odds & Matchups for Friday (4/22)

We’ve compiled odds from all of the major US sportsbooks to provide you a range of odds, as well as our consensus odds for today’s slate of MLB action. You can find moneyline, over/under, and run line odds along with each MLB matchup of the day.

What is Betting the Run Line?
The run line is a set of odds bookmakers use to balance out MLB betting action by “handicapping” the favorite while boosting the underdog. The standard run line is 1.5, which means that bettors can choose to bet on the underdog +1.5, or the favorite -1.5. The odds on these wagers are quite different from the straight moneyline odds, with the moneyline underdog turning into the run line favorite.

What is an Over/Under Bet?
Over/Under is a wager based on how many points you think will be scored in a specific game. Oddsmakers set the total, and bettors decide whether the final score will be higher or lower than that number. If an Over/Under is set at 8.5 runs and you bet Over, you will need the combined score of both teams to be 9 runs or higher to win your bet.

What is a Moneyline Bet?
A moneyline bet involves choosing which team you believe will win a specific matchup. The moneyline favorite carries a minus designation, like -130. This means that you need to wager $130 to earn a $100 profit. Conversely, the underdog carries a plus designation, like +110. This means that you win $110 in profit on a $100 bet.

Pirates @ Cubs
04/22/22 2:20 PM EDT – MLBN

View Matchup

PARTICIPANTS AND SELECTIONS
PIRATES
6-7
+145
+145
+145
+144
+140
+145
+145
+150
+145
+145
+145
+143
NL
CUBS
6-7
-175
-175
-175
-172
-160
-175
-175
-170
-167
-167
-167
-167
NL
Cardinals @ Reds
04/22/22 6:40 PM EDT

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PARTICIPANTS AND SELECTIONS
CARDINALS
7-4
-130
-125
-125
-126
-125
-128
-130
-130
-127
-130
-130
-127
NL
REDS
2-11
+110
+105
+105
+108
+105
+110
+110
+110
+110
+114
+106
+106
NL
Brewers @ Phillies
04/22/22 7:05 PM EDT

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PARTICIPANTS AND SELECTIONS
BREWERS
8-5
+110
+105
+105
+108
+105
+105
+110
+110
+110
+110
+110
+110
NL
PHILLIES
5-8
-128
-125
-125
-126
-125
-128
-130
-130
-132
-132
-132
-132
NL
Guardians @ Yankees
04/22/22 7:05 PM EDT

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PARTICIPANTS AND SELECTIONS
GUARDIANS
7-5
+170
NL
NL
+168
+170
+170
+170
+175
NL
NL
NL
NL
NL
YANKEES
7-6
-200
NL
NL
-200
-200
-213
-204
-200
NL
NL
NL
NL
NL
Rockies @ Tigers
04/22/22 7:10 PM EDT

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PARTICIPANTS AND SELECTIONS
ROCKIES
8-4
+120
+125
+125
+120
+125
+120
+120
+120
+120
+120
+120
+120
NL
TIGERS
5-7
-139
-150
-150
-142
-145
-143
-141
-140
-139
-139
-139
-148
NL
Red Sox @ Rays
04/22/22 7:10 PM EDT

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PARTICIPANTS AND SELECTIONS
RED SOX
6-7
+120
+115
+115
+120
+115
+120
+120
+120
+123
+123
+123
+120
NL
RAYS
7-6
-143
-140
-140
-142
-135
-143
-141
-140
-143
-143
-143
-143
NL
Marlins @ Braves
04/22/22 7:20 PM EDT

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PARTICIPANTS AND SELECTIONS
MARLINS
5-7
+125
+125
+125
+126
+125
+130
+125
+125
+132
+132
+132
+132
NL
BRAVES
6-8
-148
-155
-155
-148
-145
-154
-145
-145
-155
-155
-155
-165
NL
Blue Jays @ Astros
04/22/22 8:10 PM EDT

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PARTICIPANTS AND SELECTIONS
BLUE JAYS
8-5
+145
+140
+140
+138
+145
+145
+145
+150
+143
+143
+143
+143
NL
ASTROS
6-6
-167
-165
-165
-164
-165
-175
-175
-170
-167
-167
-167
-175
NL
White Sox @ Twins
04/22/22 8:10 PM EDT

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PARTICIPANTS AND SELECTIONS
WHITE SOX
6-6
-108
-105
-105
-108
-105
-105
-110
-110
-108
-108
-108
-113
NL
TWINS
5-8
-110
-115
-115
-108
-115
-115
-110
-110
-108
-108
-108
-108
NL
Orioles @ Angels
04/22/22 9:38 PM EDT

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PARTICIPANTS AND SELECTIONS
ORIOLES
4-9
+160
+155
+155
+160
+155
+160
+160
+160
+165
+165
+165
+165
NL
ANGELS
8-5
-190
-190
-190
-190
-180
-188
-196
-180
-195
-195
-195
-200
NL
Royals @ Mariners
04/22/22 9:40 PM EDT

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PARTICIPANTS AND SELECTIONS
ROYALS
5-6
+120
+115
+115
+120
+120
+120
+120
NL
+114
+114
+114
+114
NL
MARINERS
7-6
-140
-140
-140
-142
-140
-143
-141
NL
-132
-132
-132
-137
NL
Mets @ Diamondbacks
04/22/22 9:40 PM EDT

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PARTICIPANTS AND SELECTIONS
METS
10-4
-130
-130
-130
-134
-130
-133
-130
-130
-129
-129
-129
-136
NL
DIAMONDBACKS
5-8
+110
+105
+105
+114
+110
+110
+110
+110
+110
+110
+110
+110
NL
Rangers @ Athletics
04/22/22 9:40 PM EDT

View Matchup

PARTICIPANTS AND SELECTIONS
RANGERS
3-9
-128
-125
-125
NL
-130
-128
-130
-130
-125
-125
-125
-134
NL
ATHLETICS
8-6
+110
+105
+105
NL
+110
+110
+110
+110
+108
+108
+108
+108
NL
Dodgers @ Padres
04/22/22 9:40 PM EDT

View Matchup

PARTICIPANTS AND SELECTIONS
DODGERS
9-3
-175
-185
-185
-178
-165
-175
-175
-170
-177
-177
-177
-186
NL
PADRES
9-5
+150
+150
+150
+150
+145
+145
+145
+150
+150
+150
+150
+150
NL

 


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