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NFL Week 1 Same Game Parlays & Picks (2025)

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NFL Week 1 is here, and it's time to lock in some best bets and props before the games kick off. Picking matchups against the spread and betting on the over/under is more commonplace, but a Same-Game Parlay (SGP) gives us even more added action. Let's find some plus-money NFL same game parlays for every game on the NFL Week 1 Sunday afternoon slate.

Keep in mind the odds below are accurate as of writing, but are always subject to change up until kick-off. Keep track of any of the latest NFL injury news and odds movement before locking in any of these SGP bets. Without further ado, let's dive into the best NFL Week 1 same-game parlay bets.

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Best NFL Week 1 Same Game Parlay Bets 

(Odds courtesy of DraftKings Sportsbook)

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Tampa Bay Buccaneers at Atlanta Falcons 

    Rookie wideout Emeka Egbuka should be plenty involved in the Buccaneers' offense right away. Tampa is without Chris Godwin and Jalen McMillan for the start of the season, leaving a ton of targets and production up for grabs. It's a prime opportunity for Egbuka in the slot receiver role, alongside Mike Evans, in this pass-happy offense. 

    Let's double down with some Egbuka props. If we consider who he's replacing, getting to at least five receptions and 50 yards is very attainable as the slot receiver in Tampa's passing attack. Godwin had five or more catches and 50+ yards in all seven games played last year. McMillan had 50+ yards in five straight games to end the season when he was in a bigger role, including five or more catches in four of those games. 

    On the Atlanta side of things, Drake London is back as the focal point of the passing game. He should be leaned on heavily in this season opener. London averaged 74.8 receiving yards per game last year. He was especially productive later in the season, averaging 89.9 yards per contest over his last eight games. London also developed a rapport with Michael Penix Jr., as the duo connected for 106 and 187 yards in the last two games of the season. 

    Parlay Odds: +266

    Cincinnati Bengals at Cleveland Browns

      This divisional matchup may be one of Week 1's higher-scoring games. Let's take the over as we trust both offenses to turn it into a mini-shootout. The Cleveland defense has major question marks outside of Myles Garrett. It's an exploitable matchup for Joe Burrow and the Cincinnati passing game, especially with Tee Higgins and Ja'Marr Chase healthy to begin the year.

      Meanwhile, the Browns can move the ball against a Bengals defense that was a liability last year. The unit projects to struggle yet again this season. With Joe Flacco at quarterback, Cleveland's offense should be more pass-focused to start. In fact, the over is 8-3 in Flacco's last 11 starts over the past two years, with an average of 53.1 total points per game (PPG) scored in those games. 

      Speaking of Flacco, he averaged 37 pass attempts and 265.5 passing yards in his six starts last year for Indianapolis. In five starts with Cleveland in 2023, he averaged 40.8 attempts and 323.2 yards per game. He's now gone for 250+ pass yards in nine of his last 11 starts, including a perfect 5-for-5 with the Browns two seasons ago. Kevin Stefanski likely lets him chuck it around again. 

      Expect Browns tight end David Njoku to be a top target for Flacco. Two years ago, Njoku had 90+ receiving yards in three of Flacco's five starts with the Browns. Then he had 93 yards in the playoff game with Flacco at quarterback. They have a clear connection. Njoku should be heavily targeted in Week 1, especially since the Bengals allowed the most receptions to tight ends last year. 

      Parlay Odds: +325

      Miami Dolphins at Indianapolis Colts

          Jonathan Taylor was up and down from a production standpoint last season. Yet, he still ended the year on a high note, averaging 156 rushing yards over his final four games. He also finished with 1,431 rushing yards overall, averaging 102 per game. We know Taylor is the workhorse in the Colts' offense, and he should start this season strong in a favorable matchup. 

          Expect the Indy offense to lean on Taylor amid the offseason quarterback change. With Daniel Jones under center, it forces defenses to respect the pass more and thus not stack the box as much. Plus, Jones' threat to run in run-pass option (RPO) plays can give Taylor more space. Plus, the Dolphins project to be one of the worst defenses in the NFL. 

          On the Miami side, Jaylen Waddle is the player to target for Week 1. Both Tyreek Hill and De'Von Achane begin the season with injury questions. They're expected to play, but both may be limited, especially from an explosive play standpoint. Enter Waddle as the big-play option and the go-to target in the first quarter to establish a rhythm. 

          Waddle dealt with injuries and a fluctuating quarterback situation last year, yet still had 744 receiving yards with nearly 50 per game. Now that he's healthy, and Tua Tagovailoa currently is as well, it should be a bounce-back campaign for the speedy wideout. When Tagovailoa was at quarterback last year, Waddle averaged 64.6 yards per contest. Two years ago, he averaged 72.4 yards per game. 

          Parlay Odds: +360

          Las Vegas Raiders at New England Patriots

            If you play fantasy football, you already know all about the Ashton Jeanty hype. Same thing for those college football fans who watched him tear it up at Boise State. Let's grab a Jeanty prop before the rookie embarks on a potential Offensive Rookie of the Year campaign. 

            Jeanty should be featured heavily in this Raiders offense. Chip Kelly's offenses regularly produce good running back seasons, and Jeanty might be the best back he's ever had. The rookie racked up 2,601 rushing yards last year at Boise, averaging a whopping 185.8 per game. Obviously, we temper expectations as he transitions to the NFL, but don't ignore the production. 

            Look for Jeanty to get a large workload right away as the bell-cow back. He'll face a Patriots defense that allowed the third-most rushing yards to running backs last season, giving up 116 yards per game to backs. Getting to 70+ yards in this Week 1 matchup is very doable. 

            Guess who led the Patriots in targets last year? Yep, it was Hunter Henry. The tight end emerged as a favorite option for Drake Maye in the passing game. It led to Henry notching career-highs in receptions (66) and yards (674). Count on that to continue this year with an underwhelming New England wide receiver corps. 

            Henry had four or more receptions in eight of the last 10 games of the regular season last year. He also had at least 39 yards in eight of the last 11 games. Meanwhile, the Raiders allowed the sixth-most receptions and fifth-most receiving yards to tight ends last season. 

            Parlay Odds: +330

            Arizona Cardinals at New Orleans Saints

              The Cardinals should comfortably beat the rebuilding Saints this week. In the process, bank on Kyler Murray to have a good game. The Arizona quarterback sounds confident heading into the year after having one of the best seasons of his career in 2024. 

              Let's target Murray's rushing yards in Week 1. The dual-threat quarterback ran for 572 yards last year, averaging 33.6 per game. He had 25+ rush yards in nine out of 17 games. Notably, though, he was more active running-wise early in the season at his healthiest. Expect Murray to show out in this season opener.

              Meanwhile, Spencer Rattler starts for New Orleans on the other side. He also has some dual-threat upside after running for 146 yards over six starts last year. As a rookie, he showed a propensity to use his legs, with at least 27 rush yards in four of his six starts. He also averaged 22.7 rush yards per game in those starts. 

              Rattler loved throwing to his tight ends last year, and Juwan Johnson was one of his favorite targets. Johnson had 48+ receiving yards in four of Rattler's six starts in 2024. That includes 66 and 80 yards, with six catches apiece, in the final two games of the regular season. He should be a main safety valve for Rattler this week, especially with Foster Moreau and Taysom Hill out. 

              Parlay Odds: +500

              Pittsburgh Steelers at New York Jets

                This game has the under written all over it. As much as Aaron Rodgers and Justin Fields would like to get revenge on their former teams, both quarterbacks could have some growing pains with their respective offenses this week. 

                Rodgers didn't play at all in the preseason. We have to wonder what his rapport will be like with DK Metcalf and the rest of the Pittsburgh receiving corps. It may take a half or a full game for them to get on the same page. Plus, it's an Arthur Smith offense that should be run-heavy. The Jets still have a talented defense with a secondary that can frustrate Rodgers. 

                Meanwhile, Fields is a new offense himself with Tanner Engstrand in his first season as an NFL play-caller. The Jets' attack could be slow to the uptake against a tough, veteran Pittsburgh defense. It may be a run-focused offense with Breece Hall, Braelon Allen and Fields in the backfield. If both teams lean on their defense and ground game, it's an under all the way. 

                On that note, Fields is a below-average starting quarterback in the NFL, but he's still an elite rushing threat. Last year, he averaged 38.5 rush yards per game in his six starts with the Steelers. In 2023, he averaged 50.5 rushing yards per game with Chicago. Fields' legs are a true weapon, and the Jets should let him use them. 

                Parlay Odds: +395

                New York Giants at Washington Commanders

                  There was some concern whether or not Malik Nabers would suit up this week while dealing with back tightness. According to head coach Brian Daboll, the Giants' top wideout is good to go. So, let's fire up the Nabers props as he starts to build a rapport with Russell Wilson. 

                  As a rookie last year, Nabers had 1,204 receiving yards and 109 receptions. That comes out to 80.3 yards and 7.3 receptions per game. He had 60+ yards in 12 out of 15 games, and six or more catches in 11 out of 15 games. In two games against the Commanders last season, Nabers had 10 receptions for 127 yards and then nine catches for 59 yards. 

                  All the talk in Washington this preseason was the rise of rookie Jacory Croskey-Merritt, or "Bill" as he prefers. Yet, don't forget about Chris Rodriguez Jr. He could emerge as the best early-down rusher for the Commanders this year. Rodriguez didn't get many carries last year, but he made the most of them when he did. 

                  Rodriguez averaged 4.9 yards per carry last season. He racked up 94 and 52 yards in the two games when he saw double-digit carries. With Brian Robinson Jr. traded away, the door is open for Rodriguez to have a larger role now. It's also worth noting that he averaged 4.8 yards per carry in 2023 as a rookie backup. 

                  Parlay Odds: +410

                  Carolina Panthers at Jacksonville Jaguars

                    The Jaguars’ offense is expected to be more efficient and take a big step forward with Liam Coen now in town. He was the catalyst of Tampa Bay's prolific offense last season and now has plenty of weapons in Jacksonville. One of those is Brian Thomas Jr., who had 87 receptions and 1,282 yards as a rookie last year. 

                    Thomas should be the No. 1 target for Trevor Lawrence in this pass-focused offense of Coen's. Mike Evans shone in that role last year with the Buccaneers, posting another 1,000-yard season. As for Thomas, he had 70+ receiving yards in 11 out of 17 games last year. That includes seven straight to end the season. 

                    On the Carolina offense, rookie Tetairoa McMillan projects to be the top pass-catcher by default. The Panthers traded away Adam Thielen this offseason, and Jalen Coker was placed on injured reserve (IR). It sets up for McMillan to be the favorite option for Bryce Young in the passing game. In a shallow receiver corps, count on plenty of targets to get to 50+ yards. 

                    Considering the state of the Carolina wide receiver corps, the offense could go with a run-focused game plan. That would also take some pressure off Young's shoulders on the road. With that in mind, Chuba Hubbard has a good chance to score if the Panthers get near the goal line or in the red zone. Hubbard scored 11 times in 15 games last year amid a strong season. The Jaguars, meanwhile, allowed a running back touchdown in 13 out of 17 games. 

                    Parlay Odds: +355

                    Tennessee Titans at Denver Broncos

                        Let's back the Broncos on the alternate spread to kick off this parlay. Public and sharp money is on the home favorites with Titans rookie quarterback Cam Ward making his NFL debut in a tough road environment. Vance Joseph's defense is expected to be among the best this season after allowing just 18.3 PPG last year (third in the NFL). Ward could have a great rookie campaign, but this is as hard as it gets in Week 1. 

                        Check out these against the spread (ATS) trends pointing to Denver as well. No. 1 pick quarterbacks have collectively gone 8-20 ATS in their first start since 1970. The Broncos were 12-5 ATS with Bo Nix at quarterback last year. That includes a perfect 8-0 ATS as a favorite. 

                        Let's also take a Denver prop to round things out. Sophomore Troy Franklin could carve out a role in the offense right away. There's already a connection with Nix as former teammates at Oregon. Then there's the fact that the Broncos recently traded away Devaughn Vele, paving the way for more targets. 

                        Besides Courtland Sutton, there isn't a ton of competition in this wide receiver corps. Marvin Mims has a different skillset than Franklin, who can quickly emerge as the No. 2 wideout before long. This line of 18.5 receiving yards could be cleared on one or two catches. Let's bank on that happening. 

                        Parlay Odds: +340

                        San Francisco 49ers at Seattle Seahawks

                          In this NFC West matchup, let's get some exposure to both offenses. Starting with Kenneth Walker, he could be in line for a big game. The 49ers struggled against the run last year, especially later in the season. The defense didn't make any difference-making improvements in personnel, and stopping the run could be an issue to begin this year. 

                          As for Walker, he could be poised for a bounce-back season after dealing with injuries last year. Plus, with Klint Kubiak as Seattle's new play-caller, the run game should be much more effective with Walker featuring as the bell-cow back. Getting to 60+ yards is a low bar for a guy who averaged 60.3 yards per game two seasons ago and 70 yards per game in 2022. 

                          The San Francisco offense is severely lacking trustworthy wide receivers to begin the season. Deebo Samuel is gone, and Brandon Aiyuk is out to start the year. It leaves Jauan Jennings in a prime position to be a go-to option for Brock Purdy, outside of George Kittle. Last year, Jennings took advantage of his bigger role with 975 yards and a 65-yard per game average. He also had 40+ yards in 11 out of 15 games. 

                          While Johnson can cash his prop, Purdy is fadeable from a passing perspective overall. Don't expect him to chuck it around a ton. Last year, he averaged 30.3 pass attempts per game. That was with Christian McCaffrey sidelined for most of the season. Since McCaffrey is back, and the Niners traded for Brian Robinson Jr., the offense should feature the run more this year. Purdy is also better in the game-manager role, where he's not throwing it 30+ times. 

                          Parlay Odds: +525 

                          Detroit Lions at Green Bay Packers

                            The line movement in this NFC North clash is interesting. The Lions were favored over the summer, but the Packers have since moved to nearly a field goal favorite. Let's follow the trend and back Green Bay to start our parlay. The Moneyline is much safer than worrying about the spread. 

                            Detroit won both regular-season meetings last year in this rivalry. The Packers should be plenty motivated to flip the script this year. Jordan Love is poised to take another step forward manning the offense, and the defense just got a big boost in adding Micah Parsons. There's also some negative regression likely coming for the Lions' offense after losing Ben Johnson. 

                            Plus, check out these trends. Packers coach Matt LaFleur is great at covering early spreads. Since he took over in 2019, Green Bay has gone 15-3 ATS over the first three games of the season under LaFleur. That includes a perfect 7-0 ATS mark at home. 

                            Rookie Matthew Golden can be a key playmaker for the Packers this season, and it starts in Week 1. The Green Bay wide receiver corps is without Christian Watson to begin the year. Jayden Reed also comes in banged up. Meanwhile, Golden received plenty of hype in the preseason while building a connection with Love. The Lions allowed the most yards to opposing wide receivers last year, and Golden has the speed and big-play ability to get 50+ yards on 2-3 catches. 

                            Meanwhile, Lions wideout Jameson Williams can also have a good day. He'll be going up against a Green Bay secondary with question marks. In this matchup last year, he had five catches for 80 yards. He's a big play waiting to happen, and he enters the year fully healthy. While Green Bay focuses on shutting down Jahmyr Gibbs and Amon-Ra St. Brown, it's Williams who can find space to get to 50+ yards himself. 

                            Parlay Odds: +485

                            Houston Texans at Los Angeles Rams

                              The total in this game has dropped since opening at 46 over the summer. There are concerns about early-season rust on both offenses, which could result in a lower-scoring game. Let's take the under on the alternate total to kick us off. 

                              Houston's offense comes in with injuries and question marks. Joe Mixon is sidelined to begin the season, while wideouts Christian Kirk and Braxton Berrios are both out with hamstring injuries. The offensive line, which struggled last year, could be a liability again this season. It's not an ideal situation for C.J. Stroud against a talented Rams defense with a strong pass rush.  

                              Meanwhile, the Rams' offense could also start slow. Sean McVay not playing his starters in the preseason has resulted in the Rams scoring 10, 13 and 20 points in Week 1 over the past three years. For this year's opener, 37-year-old quarterback Matthew Stafford will especially need to shake off some rust after nursing a back injury throughout training camp. 

                              As noted above, the Texans' receiving corps is down some key players with Kirk and Berrios sidelined. That opens up the door for second-round rookie Jayden Higgins. Of course, Nico Collins is still the No. 1 wideout. Higgins, though, has the opportunity for quick catches as the second option in the passing game for Stroud. 

                              Parlay Odds: +340

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