Premier League Matchday 28 Odds, Picks & Predictions (2026)
Only 11 matchdays remain in the 2025-26 English Premier League season, and it's shaping up to be a two-team race atop the table. Arsenal is currently a moderately priced -200 favorite to secure the title, while Manchester City is right behind them at +160.
From a sports betting perspective, we're riding a hot streak on the pitch. We're fresh off of a 3-0 Champions League sweep during the midweek, and I'm looking to bring the heater back to England. Here are my top Premier League wagers for Matchday 28.
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Premier League Matchday 28 Preview & Best Bets (2026)
(Odds courtesy of DraftKings Sportsbook)
Wolves (+330) vs. Aston Villa (-115), DRAW (+265) | O/U 2.5 (-115/-110)
The weekend gets started with a standalone match on Friday, as Wolves (1-7-20, 10 points) gear up to host Aston Villa (15-6-6, 51 points). The Villans currently occupy a coveted top-four spot in the table, entering the weekend ranked third. Kick-off is scheduled for 3:00 p.m. ET from Molineux Stadium in Wolverhampton.
How can we pass up on a pick 'em price with Aston Villa against the worst team in the league? We have to back the visitors at -115 on the moneyline. They'll take on a Wolverhampton Wanderers side that ranks last at 1-7-20. Yeah, that's not a typo, they've really only won one of their 28 matches this season. They're also last in goal differential at -33 (18:51), and to put that into perspective, the next-closest team is Burnley at -23 (29:52).
Aston Villa likely won't need much offense to escape with the three points on Friday. They should be able to lean on their defense, which has been sharp this season. The Villans rank third in goals allowed (28), seventh in clean sheet percentage (29.6%), and first in team save percentage (74.8%). They should have no issues putting the clamps on this Wolves squad that's averaging a measly 0.6 goals per match, ultimately departing Wolverhampton with a low-scoring victory.
Pick: Aston Villa Moneyline (-115)
Burnley (+360) vs. Brentford (-135), DRAW (+290) | O/U 2.5 (-120/-105)
Saturday's five-match slate features a fun matchup in Burnley, as the 19th-place Clarets (4-7-16, 19 points) square off against the Bees (12-4-11, 40 points) of Brentford. Keith Andrews' men are coming off of a 2-0 home loss to Brighton, but they still reside in seventh place in the Premier League standings. This match gets underway at 10:00 a.m. ET from Turf Moor in Burnley.
I was leaning towards playing Brentford on the moneyline in this match, but I actually think this could be a vulnerable spot for them. They haven't been overpowering recently, going 0-1-1 in their last two Premier League matches. The Bees have also struggled on the road, posting a 5-0-8 record with a -6 goal differential (16:22).
Brentford has been susceptible defensively this term, so I ultimately think it's best to play the Over in this one. I can see this match landing 2-1, clearing the 2.5-goal threshold. Speaking of unfortified defenses, Burnley quickly comes to mind. Their 52 goals against in 27 matches (1.9 GA/G) is the worst in the league. The Clarets have conceded 2+ goals four of their last five matches, as well as in seven of their last nine outings. Let's take the Over in this matchup featuring two lousy defenses.
Pick: Over 2.5 Goals (-120)
Arsenal (-160) vs. Chelsea (+425), DRAW (+310) | O/U 2.5 (-145/+115)
All roads lead to a marquee clash on Sunday morning, as league leaders Arsenal (18-7-3, 61 points) take on a Chelsea team (12-9-6, 45 points) that's picking up steam. The teams rank first and fifth in the table, respectively. The matchday finale is slated for 11:30 a.m. ET from Emirates Stadium in London.
This game is going to be awesome, but I also think it could turn into a bit of a snoozefest. Arsenal has just been so dominant defensively once again this season. They sit atop the table in goals allowed (21) and clean sheet percentage (46.4%), while having allowed the fewest overall shots on target (62) this season. They've played 28 matches, meaning they're only giving up 2.2 SoT per match. That's a full shot less than the next-closest teams (Liverpool & Manchester City at 3.4).
Chelsea has also been dialed in defensively this season. They're fourth in goals against (31), and their 15 goals allowed on the road is the fourth-best as well. Circling back to Arsenal while we're on the topic of home-road form, they've only conceded eight goals at home in 13 matches. It's also worth noting that the last three Premier League matches between the clubs have finished under 2.5 combined goals. Let's take the Under.
Pick: Under 2.5 Goals (+115)