There were some massive breakout performances in Week 9, including 40-year-old Joe Flacco breaking his own personal record by throwing for 470 passing yards in a 47-42 loss to the Bears. In the same game, Kyle Monangai rushed for 176 yards and Tee Higgins caught seven passes for 121 yards and two touchdowns.
Below, I've listed three players who I believe are primed to go nuclear in the NFL this weekend. I'm betting each player to clear his baseline yardage prop, as well as eclipse some of their higher alternate lines with loftier payouts. Here are my top NFL Week 10 ladder bets.
Get instant alerts when a line reaches your target via the BettingPros App >>
Best NFL Week 10 Ladder Bets
(Odds courtesy of bet365)
Kyle Pitts Receiving Yards
Let's get things started bright and early, where the Falcons (3-5) and Colts (7-2) square off in Berlin. Kick-off is scheduled for 9:30 a.m. ET from Olympiastadion Berlin in Berlin, Germany.
The Colts have been a wagon this season, but if there's one area where they've been susceptible, it's their pass defense. Now, whether that's an actual issue with their secondary, or simply because teams have been trailing and forced to pass against them is up for debate. Regardless, Indianapolis is allowing 244.8 passing yards per game (26th), and opposing quarterbacks are completing 65.8% of their passes against them (15th). Pro Football Focus (PFF) grades them as the 21st-best pass coverage unit.
I'll try climbing the ladder with Kyle Pitts on Sunday morning. While Drake London is the top target in the passing attack, his 47 receptions are only four more than Pitts' 43 catches this season. He's just as important in Atlanta's pass game. Pitts is averaging 47.8 receiving yards per game, and he has cleared the 46-yard threshold in half of his games in 2025.
Mark Andrews Receiving Yards
Onto the mid-day slate, where we have a pivotal matchup between a couple of playoff hopefuls. The Vikings (4-4) are coming off a big win over the Lions, and they'll try to keep things rolling against a Ravens squad (3-5) that has won two straight games. Kick-off is set for 1:00 p.m. ET from U.S. Bank Stadium in Minneapolis, MN.
I was initially thinking about playing Zay Flowers in this game, but considering the Vikings blitz at the second-highest rate (40.6%) in the NFL, I don't think the speedster will have enough time to develop his mid-to-deep routes with Lamar Jackson under pressure. Instead, I think it's better to take a short-to-mid range/checkdown option like Mark Andrews.
Andrews has cleared the 29.5-yard threshold three times in his last six games, and he's averaging 4.8 targets per game during that sample size. Minnesota is graded as the 24th-best pass coverage unit at PFF, as well as the 24th-best tackling defense. A couple of mid-range catches mixed with some yards after the catch, and we will be well on our way to climbing this ladder.
Amon-Ra St. Brown Receiving Yards
It has been a rough season for the Commanders (3-6), and things likely won't get better when the 8.5-point underdogs host the Lions (5-3) on Sunday afternoon. This NFC Divisional Round rematch gets underway at 4:25 p.m. ET from Northwest Stadium in Landover, MD.
Amon-Ra St. Brown is turning in another monster campaign, as he enters the weekend ranked fourth in receptions (59), sixth in receiving yards (635) and second in receiving touchdowns (seven). His 9.3 targets per game are the seventh-most in the NFL, and his 7.8 touches per game are the fourth-most amongst receivers. St. Brown has cleared the 80-yard threshold three times in the last four games, as well as hitting the 100-yard mark twice in the last seven weeks.
This will be a nice matchup for this high-powered Detroit offense. They'll take on a Washington defense allowing 253.6 passing yards per game (29th). The Commanders are ranked as the second-worst pass coverage unit, according to PFF, while the defense as a whole is a pedestrian 18th in tackling. St. Brown's primed for a monster outing on Sunday afternoon.
