We've got a busy day of NFL preseason action. I'm talking about eight games, starting at 1:00 p.m. EST with the Giants and Bills and ending at 8:30 p.m. EST with the Broncos and 49ers. From a betting perspective, there are several good opportunities. But which ones are the best? That's never an easy question to answer, but it becomes even more challenging during the preseason since winning is not a priority. But that doesn't stop us from separating the best NFL preseason picks and bets for Broncos vs. 49ers.
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Saturday’s Best NFL Preseason Picks: Broncos vs. 49ers
(Odds courtesy of FanDuel Sportsbook)
Denver Broncos (-6.5) vs. San Francsico 49ers (+240) | O/U 34.5 (-115/-105)
We can expect to see Bo Nix play for about a quarter for the Denver Broncos; head coach Sean Payton has said his starters will play. But this being the first preseason game, fans shouldn't expect to see them for long. San Francisco has not provided specifics as to who or how long starters will play.
Kyle Shanahan is 12-11-1 straight up (SU) in preseason games and 13-10-1 against the spread (ATS). Sean McDermott went 3-0 last season, his first in Denver, but has a 33-33 all-time preseason record.
This is a pretty low total, but I don't expect to see Nix for long. Once he's gone, the Broncos’ chances of producing on offense will go away, too. With Brock Purdy out and several key players listed as questionable, we will not see many - if any stars (or offense) - for the 49ers.
Pick: Under 34.5 Points (-105)
